Complementary information concerning the suspected interindividual transmission of GW1516, a substance prohibited in sport, through intimate contact: a case report.

PURPOSE: Inadvertent and/or unknowing exposure to drugs and drug residues has been frequently debated in situations of so-called adverse analytical finding (AAF) in the context of sports drug testing programs. Transfer of drug residues via unprotected intercourse is a conceivable scenario but scientific data and authentic case reports are scarce. Herein, investigations into two AAFs with the peroxisome proliferator-activated receptor delta (PPARδ) agonist GW1516 are reported and discussed. METHODS: To probe for a contamination scenario involving sexual intercourse, two assays were used to determine semenogelin in human urine, with one employing an immunochromatographic lateral flow approach and another based on liquid chromatography-tandem mass spectrometry. Further, drug-residue testing using patients' ejaculate was conducted by utilizing liquid chromatography in conjunction with a triple quadrupole mass spectrometer, followed by re-analysis of suspect samples (i.e., samples indicating the presence of relevant compounds) using high resolution/high mass accuracy mass spectrometry. RESULTS: In one case, but not the other, the possibility of intimate contact as the source of the AAF was confirmed after a thorough investigation of potential contamination scenarios. Subsequent research revealed analytical evidence for the presence of seminal fluid in one of the female athlete's doping control urine samples, and the analysis of clinical ejaculate specimens provided first data on an authentic concentration level of GW1516 and its metabolites in human seminal fluid. CONCLUSIONS: The combined facts substantiate the possibility of an AAF caused by unprotected sexual intercourse and the plausibility of the case-related arguments.

Nonlinear beam tapering and two-dimensional ring solitons.

We examine a possibility to exploit the nonlinear lens effect-the initial stage of self-focusing to localize initially broad field distribution into the small central area where wave collapse is arrested-the nonlinear beam tapering. We describe two-dimensional localized solitary waves (ring solitons) in a physical system that presents a linear medium in the central core, surrounded by the cladding with the focusing Kerr nonlinearity. The standard variational analysis demonstrates that such solitons correspond to the minimum of the Hamiltonian.

Thermalization of Orbital Angular Momentum Beams in Multimode Optical Fibers.

We report on the thermalization of light carrying orbital angular momentum in multimode optical fibers, induced by nonlinear intermodal interactions. A generalized Rayleigh-Jeans distribution of asymptotic mode composition is obtained, based on the conservation of the angular momentum. We confirm our predictions by numerical simulations and experiments based on holographic mode decomposition of multimode beams. Our work establishes new constraints for the achievement of spatial beam self-cleaning, giving previously unforeseen insights into the underlying physical mechanisms.

Nonlinear Fourier transform for analysis of optical spectral combs.

The nonlinear Fourier transform (NFT) is used to characterize the optical combs in the Lugiato-Lefever equation with both anomalous and normal dispersion. We demonstrate that the NFT signal processing technique can simplify analysis of the formation of dissipative dark solitons and regimes exploiting modulation instability for a generation of coherent structures, by approximating the comb with several discrete eigenvalues, providing a platform for the analytical description of dissipative coherent structures.

Statistical properties of nonlinear distortion of a polarization-multiplexed OFDM signal in long-haul fiber links.

We investigate nonlinear transmission regimes of a polarization-multiplexed 16-quadrature amplitude modulation (PDM-16-QAM) orthogonal frequency-division multiplexed (OFDM) signal in a long-haul optical link. We study the dependence between the strength of nonlinear distortion and statistical properties of a PDM-OFDM signal. We also consider the constellation shaping-based solutions that allow to significantly reduce the bit error rate (up to three to 12 times at the cost of 5%-20% signal redundancy) and propose a method to analytically optimize the symbol distribution for higher-order modulation formats using only the initial signal.

Raman dissipative solitons generator near 1.3 mkm: limiting factors and further perspectives.

Raman dissipative solitons (RDS) have been investigated numerically. It was found that the area of stable generation is bounded in terms of pump spectral bandwidth and pulse energy. Existing optimum is strongly affected by the net cavity dispersion. The spectral bandwidth of the generated RDS linearly depends on its energy and reaches more than 50 nm in the 5-meters long cavity. Developed numerical model reproduces all the effects observed experimentally. It predicts ability to generate high-quality pulses with energy up to 6 nJ compressible down to ∼100 fs duration. The work shows that RDS generation technique can produce high-energy ultrashort pulses at wavelengths not covered by typical active mediums.

Finding spatiotemporal light bullets in multicore and multimode fibers.

A two-level iterative algorithm for finding stationary solutions of coupled nonlinear Schrödinger equations describing the propagation dynamics of an electromagnetic pulse in multimode and multicore optical fibers of various structures was developed and tested. Using as an example the proposed analytical soliton solution which is localized in space and time, test calculations were performed, and the convergence of the algorithm was demonstrated.

Nonlinear Fourier Transform for Analysis of Coherent Structures in Dissipative Systems.

Using the cubic Ginzburg-Landau equation as an example, we demonstrate how the inverse scattering transform can be applied to characterize coherent structures in dissipative nonlinear systems. Using this approach one can reduce the number of the effective degrees of freedom in the system when the dynamic is dominated by the coherent structures, even if they are embedded in the dispersive waves and demonstrate unstable behavior.

Hydrodynamic 2D Turbulence and Spatial Beam Condensation in Multimode Optical Fibers.

We show that Kerr beam self-cleaning results from parametric mode mixing instabilities that generate a number of nonlinearly interacting modes with randomized phases-optical wave turbulence, followed by a direct and inverse cascade towards high mode numbers and condensation into the fundamental mode, respectively. This optical self-organization effect is an analogue to wave condensation that is well known in hydrodynamic 2D turbulence.

Simple geometric interpretation of signal evolution in phase-sensitive fibre optic parametric amplifier.

Visualisation of complex nonlinear equation solutions is a useful analysis tool for various scientific and engineering applications. We have re-examined the geometrical interpretation of the classical nonlinear four-wave mixing equations for the specific scheme of a phase sensitive one-pump fiber optical parametric amplification, which has recently attracted revived interest in the optical communications due to potential low noise properties of such amplifiers. Analysis of the phase portraits of the corresponding dynamical systems provide valuable additional insight into field dynamics and properties of the amplifiers. Simple geometric approach has been proposed to describe evolution of the waves, involved in phase-sensitive fiber optical parametric amplification (PS-FOPA) process, using a Hamiltonian structure of the governing equations. We have demonstrated how the proposed approach can be applied to the optimization problems arising in the design of the specific PS-FOPA scheme. The method considered here is rather general and can be used in various applications.

Theoretical analysis of saturable absorbtion in passively mode-locked fiber lasers.

We propose a general analytical method for estimation of the saturable absorber output energy as a function of the input energy. The method is based on a representation of the saturable absorber output energy as a series of powers of the recovery time. We also derive a simplified expression of the saturable absorber output energy that gives a good approximation for large input energies. The analytical results are verified by the numerical simulation. The results have been applied to the particular cases of an input function that include the Gaussian input pulse and the hyperbolic secant input pulse. We show that the analytical results can improve the prediction of the output energy in the fiber lasers.

Nonlinear pulse combining and pulse compression in multi-core fibers.

We demonstrate light pulse combining and pulse compression using a continuous-discrete nonlinear system implemented in a multi-core fiber (MCF). It is shown that the pulses initially injected into all of the cores of a ring MCF are combined by nonlinearity into a small number of cores with simultaneous pulse compression. We demonstrate the combining of 77% of the energy into one core with pulse compression over 14× in a 20-core MCF. We also demonstrate that a suggested scheme is insensitive to the phase perturbations. Nonlinear spatio-temporal pulse manipulation in multi-core fibers can be exploited for various applications, including pulse compression, switching, and combining.

Pathology, toxicology, and latency of irritant gases known to cause bronchiolitis obliterans disease: Does diacetyl fit the pattern?

Bronchiolitis obliterans (BO) is a rare disease involving concentric bronchiolar fibrosis that develops rapidly following inhalation of certain irritant gases at sufficiently high acute doses. While there are many potential causes of bronchiolar lesions involved in a variety of chronic lung diseases, failure to clearly define the clinical features and pathological characteristics can lead to ambiguous diagnoses. Irritant gases known to cause BO follow a similar pathologic process and time course of disease onset in humans. Studies of inhaled irritant gases known to cause BO (e.g., chlorine, hydrochloric acid, ammonia, nitrogen oxides, sulfur oxides, sulfur or nitrogen mustards, and phosgene) indicate that the time course between causal chemical exposures and development of clinically significant BO disease is typically limited to a few months. The mechanism of toxic action exerted by these irritant gases generally involves widespread and severe injury of the epithelial lining of the bronchioles that leads to acute respiratory symptoms which can include lung edema within days. Repeated exposures to inhaled irritant gases at concentrations insufficient to cause marked respiratory distress or edema may lead to adaptive responses that can reduce or prevent severe bronchiolar fibrotic changes. Risk of BO from irritant gases is driven substantially by toxicokinetics affecting concentrations occurring at the bronchiolar epithelium. Highly soluble irritant gases that cause BO like ammonia generally follow a threshold-dependent cytotoxic mechanism of action that at sufficiently high doses results in severe inflammation of the upper respiratory tract and the bronchiolar epithelium concurrently. This is followed by acute respiratory distress, pulmonary edema, and post inflammatory concentric fibrosis that become clinically obvious within a few months. In contrast, irritant gases with lower solubility like phosgene also follow a threshold-dependent mechanism of cytotoxicity action but can exhibit more insidious and isolated bronchiolar tissue damage with a similar latency to fibrosis. To date, animal and human studies on the highly soluble gas, diacetyl, have not identified a coherent pattern of pathology and latency that would be expected based on studies of other known causes of bronchiolitis obliterans disease.

Timing and phase jitter suppression in coherent soliton transmission.

We have revisited soliton transmission in the new context of coherent optical detection optimizing and comparing digital backward propagation and in-line optical filtering as a means to suppress soliton timing and phase jitter. We find that in-line optical filtering allows one to improve the reach of the soliton system by up to the factor of 2. Our results show that nonlinear propagation can lead to performance beyond the nonlinear Shannon limit.

Simplified method for numerical modeling of fiber lasers.

A simplified numerical approach to modeling of dissipative dispersion-managed fiber lasers is examined. We present a new numerical iteration algorithm for finding the periodic solutions of the system of nonlinear ordinary differential equations describing the intra-cavity dynamics of the dissipative soliton characteristics in dispersion-managed fiber lasers. We demonstrate that results obtained using simplified model are in good agreement with full numerical modeling based on the corresponding partial differential equations.

Power-controlled phase-matching and instability of CW propagation in multicore optical fibers with a central core.

We present modulation instability analysis including azimuthal perturbations of steady-state continuous wave (CW) propagation in multicore-fiber configurations with a central core. In systems with a central core, a steady CW evolution regime requires power-controlled phase matching, which offers interesting spatial-division applications. Our results have general applicability and are relevant to a range of physical and engineering systems, including high-power fiber lasers, optical transmission in multicore fiber, and systems of coupled nonlinear waveguides.

Evolution of dissipative solitons in a fiber laser oscillator in the presence of strong Raman scattering.

As recently revealed, chirped dissipative solitons (DSs) generated in a long cavity fiber laser are subject to action of stimulated Raman scattering (SRS). Here we present theoretical and experimental study of the DS formation and evolution in the presence of strong SRS. The results demonstrate that the rising noisy Raman pulse (RP) acts not only as an additional channel of the energy dissipation destroying DS, but on the contrary can support it that results in formation of a complex of the bound DS and RP of comparable energy and duration. In the complex, the DS affords amplification of the RP, whereas the RP stabilizes the DS via temporal-spectral filtering. Stable 25 nJ SRS-driven chirped DS pulses are generated in all-fiber ring laser cavities with lengths of up to 120 m. The DS with duration up to 70 ps can be externally dechirped to <300 fs thus demonstrating the record compression factor.

Numerical modeling of fiber lasers with long and ultra-long ring cavity.

We highlight two important aspects related to a mathematical modeling of pulsed fiber lasers with long and ultra-long ring cavity -impact of an initial noise and a cavity length on generation of single optical pulses. Using as an example a simple scalar model of a ring fiber laser that describes the radiation build-up from noise and the following intra-cavity pulse dynamics during a round trip we study dependence of generated pulse characteristics on the resonator length in the range from 30 m up to 2 km.

Generation dynamics of the narrowband Yb-doped fiber laser.

We present direct real-time experimental measurements and numerical modeling of temporal and statistical properties for the Ytterbium-doped fiber laser with spectral bandwidth of ~2 GHz. The obtained results demonstrate nearly exponential probability density function for intensity fluctuations. A significant decrease below the Gaussian probability has been experimentally observed for intensity fluctuations having value more than 2.5 of average intensity that may be treated as indication of some mode correlations.

Hybrid gain-flattened and reduced power excursion scheme for distributed Raman amplification.

We propose and evaluate through extensive numerical modelling a novel distributed hybrid amplification scheme combining first and second-order Raman pumping which gives reduced signal power excursion over a wide spatial-spectral range of 60 km × 80 nm in C + L-bands.