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1.
Bull Exp Biol Med ; 162(5): 594-596, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28361416

RESUMO

Characteristics of depressive-like behavior of male rats with androgen deficiency born by mothers subjected to prenatal stress during pregnancy were assessed by using Porsolt tests and open-field tests. The level of depression-like behavior in prenatally stressed males increased more intensively than in non-stressed gonadectomized males. Chronic administration of testosterone propionate (0.5 mg/kg, intramuscularly, for 14 days) increased depressive behavior in prenatally stressed gonadectomized males in contrast to its antidepressant effect in nonstressed gonadectomized rats. Prenatal stress considerably exacerbated depressive behavior of male rats under conditions of androgen deficiency and abolished the antidepressant effect of exogenously administered testosterone propionate.


Assuntos
Depressão/sangue , Efeitos Tardios da Exposição Pré-Natal/sangue , Estresse Psicológico/complicações , Testosterona/deficiência , Animais , Antidepressivos/administração & dosagem , Depressão/etiologia , Feminino , Injeções Intramusculares , Masculino , Gravidez , Efeitos Tardios da Exposição Pré-Natal/etiologia , Ratos , Estresse Psicológico/sangue , Testosterona/administração & dosagem
2.
Bull Exp Biol Med ; 156(5): 612-4, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24770740

RESUMO

We studied the effects of dopamine D1/D2 receptor antagonists on the dynamics of acquisition and extinction of active avoidance responses and open field behavior in ovariectomized female rats. Dopamine D1 receptor antagonist SCH-23390 (0.1 mg/kg intraperitoneally) and dopamine D2 receptor antagonist sulpiride (10.0 mg/kg intraperitoneally) were administered chronically (14 days) either alone or in combination with a low dose of 17ß-estradiol (0.5 µg per rat subcutaneously) to females after ovariectomy. It was found that SCH-23390 in combination with a low dose of 17ß-estradiol completely restored impaired conditioning and retention of a conditioned avoidance response in ovariectomized animals. Simultaneous correction of behavioral patterns in the open field test was also observed in ovariectomized females receiving SCH-23390. Sulpiride injected alone or in combination with low dose of 17ß-estradiol did not correct conditioning and reproduction of active avoidance response in females with estrogen deficiency and did not significantly affect animal behavior. The results indicate positive effect of dopamine D1 receptor blockade on active learning under conditions of estrogen deficiency.


Assuntos
Aprendizagem da Esquiva/efeitos dos fármacos , Benzazepinas/farmacologia , Antagonistas de Dopamina/farmacologia , Estradiol/administração & dosagem , Sulpirida/farmacologia , Animais , Condicionamento Psicológico/efeitos dos fármacos , Avaliação Pré-Clínica de Medicamentos , Estrogênios/deficiência , Feminino , Atividade Motora/efeitos dos fármacos , Ovariectomia , Ratos Wistar
3.
Patol Fiziol Eksp Ter ; (3): 37-41, 2013.
Artigo em Russo | MEDLINE | ID: mdl-24340617

RESUMO

The aim of this work was to study the influence of stimulation or blockade Nalpha7-cholinoreceptors on dynamics of spatial learning in water Morris maze and on behavior in the "open field" test in adult ovariectomized (OVX) females given with a low dose of 17beta-estradiol. Agonist of Nalpha7-cholinoreceptors - RJR-2403 (1.0 mg/kg, i.p.) or antagonist of Nalpha7-cholinoreceptors - mecamylamine (1.0 mg/kg, i.p.) treated chronically (14 days) alone and in a combination with low dose of 17beta-estradiol (0.5 micro/rat, s.c.) to OVX rats. Co-administration of RJR-2403 with low dose of 17beta-estradiol completely restored impaired spatial learning in water Morris maze in OVX females. Moreover, OVX rats treated with RJR-2403 and low dose of 17beta-estradiol demonstrated increased exploratory and grooming behavior in the "open field" test. Both mecamylamine alone and in combination with low dose of 17beta-estradiol failed to influence on spatial learning and failed to modify behavior in the "open field" test in OVX rats. The results of the present study suggest a positive effect of RJR-2403 in combination with low dose of 17beta-estradiol on spatial learning at estrogen deficiency.


Assuntos
Antagonistas Colinérgicos/farmacologia , Estradiol/farmacologia , Aprendizagem em Labirinto/efeitos dos fármacos , Nicotina/análogos & derivados , Animais , Antagonistas Colinérgicos/administração & dosagem , Sinergismo Farmacológico , Estradiol/administração & dosagem , Estrogênios/deficiência , Feminino , Asseio Animal/efeitos dos fármacos , Nicotina/administração & dosagem , Nicotina/farmacologia , Ovariectomia , Ratos , Ratos Wistar
4.
Bull Exp Biol Med ; 155(4): 433-5, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24298652

RESUMO

The comparative analysis of hormonal status was performed in mature female rats with experimental deficiency of estrogens, which mothers were exposed to stress during pregnancy. High levels of follicle-stimulating hormone and luteinizing hormone, and significantly lower amount of estradiol were observed in intact prenatally stressed females in comparison with intact non-stressed female rats. The increase in the levels of follicle-stimulating hormone and luteinizing hormone, and the decrease in estradiol concentration were more pronounced in blood serum of prenatally stressed ovariectomized rats as distinct from intact non-stressed and prenatally stressed female rats, and non-stressed ovariectomized female rats. We can conclude that prenatally stressed ovariectomized rats were characterized by an increased sensitivity to exogenous hormonal interventions and high lability of functional state of the pituitary-ovarian system.


Assuntos
Ovário/fisiopatologia , Hipófise/fisiopatologia , Efeitos Tardios da Exposição Pré-Natal/sangue , Estresse Fisiológico , Animais , Estradiol/sangue , Feminino , Hormônio Foliculoestimulante/sangue , Hormônio Luteinizante/sangue , Ovariectomia , Hipófise/metabolismo , Gravidez , Progesterona/sangue , Ratos , Ratos Wistar
5.
Patol Fiziol Eksp Ter ; (4): 64-7, 2013.
Artigo em Russo | MEDLINE | ID: mdl-24640778

RESUMO

The aim of the present work was an estimation of effects of chronic administration of selective serotonin reuptake inhibitors--fluoxetine (5.0 mg/kg, p.o.) and paroxetine (5.0 mg/kg, p.o.) for 14 days of postnatal period on anxiety-like behavior in the prenatally stressed male rats during pubertal period (1,5 month) and the adult state (3 month). Chronic paroxetine administration to females failed to change an anxiety-like behavior independently from age. On the contrary, administration of fluoxetine resulted in modulating influence on the anxiety-like behavior of prenatally stressed rats dependently from age: anxiolytic effect was noted in young males, while anxiogenic effect was observed in the adult male rats.


Assuntos
Ansiedade/tratamento farmacológico , Fluoxetina/uso terapêutico , Paroxetina/uso terapêutico , Efeitos Tardios da Exposição Pré-Natal/tratamento farmacológico , Inibidores Seletivos de Recaptação de Serotonina/uso terapêutico , Animais , Ansiedade/etiologia , Feminino , Fluoxetina/farmacologia , Locomoção/efeitos dos fármacos , Masculino , Paroxetina/farmacologia , Gravidez , Efeitos Tardios da Exposição Pré-Natal/etiologia , Ratos , Ratos Sprague-Dawley , Inibidores Seletivos de Recaptação de Serotonina/farmacologia , Fatores Sexuais , Estresse Psicológico/complicações
6.
Eksp Klin Farmakol ; 74(4): 3-5, 2011.
Artigo em Russo | MEDLINE | ID: mdl-21678650

RESUMO

We present the results of a comparative analysis of the effects of the chronic administration of the selective serotonin reuptake inhibitors fluoxetine (5.0 mg/kg, p.o.) and paroxetine (5.0 mg/kg, p.o.) for 14 days of the postnatal period on anxiety-like behavior in the prenatally stressed male rats as studied during pubertal period (1.5 month) and in the adult age (3 month). The chronic administration of paroxetine in male rats did not change the anxiety-like behavior in male rates of any age. On the contrary, the administration of fluoxetine modulated the anxiety-like behavior of prenatally stressed rats depending on the age: the anxiolytic effect was observed in young males, while the anxiogenic effect was observed in adult male rats.


Assuntos
Ansiolíticos/administração & dosagem , Ansiedade/prevenção & controle , Ansiedade/fisiopatologia , Fluoxetina/administração & dosagem , Paroxetina/administração & dosagem , Inibidores Seletivos de Recaptação de Serotonina/administração & dosagem , Fatores Etários , Animais , Antidepressivos de Segunda Geração/administração & dosagem , Ansiedade/metabolismo , Comportamento Animal/efeitos dos fármacos , Feminino , Masculino , Gravidez , Efeitos Tardios da Exposição Pré-Natal , Ratos , Ratos Sprague-Dawley , Fatores Sexuais , Estresse Psicológico/metabolismo , Estresse Psicológico/fisiopatologia
7.
Bull Exp Biol Med ; 150(1): 6-8, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21161037

RESUMO

We studied the effects of chronic administration (14 days) of agonist of 5-HT2B/2C serotonin receptors m-CPP (0.5 mg/kg subcutaneously) and agonist of 5-HT2A/2C serotonin receptors ketanserin (0.1 mg/kg intraperitoneally) on conditioned reactions in female rats in different phases of the estrous cycle. Passive avoidance (PA) paradigm and Morris water maze were used as behavioral tests. Chronic administration of m-CPP did not affect PA retrieval during the proestrus and estrus phases, but improved the dynamics of spatial learning in Morris water maze in comparison with control rats. Chronic administration of ketanserin uniformly impaired processes of spatial and nonspatial learning in female rats irrespective to the phase of the estrous cycle. A modulating role of 5-HT2A/2C and 5-HT2B/2C serotonin receptors in process of learning in female rats during the key phases of the estrous cycle was demonstrated.


Assuntos
Ciclo Estral/efeitos dos fármacos , Ketanserina/farmacologia , Aprendizagem/efeitos dos fármacos , Piperazinas/farmacologia , Receptor 5-HT2A de Serotonina/metabolismo , Receptor 5-HT2C de Serotonina/metabolismo , Análise de Variância , Animais , Feminino , Aprendizagem em Labirinto/efeitos dos fármacos , Ratos , Ratos Wistar , Receptor 5-HT2B de Serotonina/metabolismo , Agonistas do Receptor 5-HT2 de Serotonina/farmacologia
8.
Bull Exp Biol Med ; 149(5): 601-3, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21165397

RESUMO

Experiments on rats with myocardial ischemia modeled by occlusion of the left coronary artery aggravated by alimentary dislipoproteinemia showed that therapy with taurepar (50 mg/kg), a taurine derivative, decreased blood corticosterone concentration and increased the level of endogenous testosterone, which attests to normalization of the compensatory-adaptive and gonadotropic functions of the organism.


Assuntos
Isquemia Miocárdica/fisiopatologia , Taurina/análogos & derivados , Testosterona/deficiência , Animais , Corticosterona/sangue , Gorduras na Dieta/administração & dosagem , Dislipidemias/tratamento farmacológico , Masculino , Isquemia Miocárdica/complicações , Ratos , Taurina/uso terapêutico , Testosterona/sangue
9.
Bull Exp Biol Med ; 150(2): 165-7, 2010 Dec.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-21246079

RESUMO

We studied the effect of chronic administration of 5-HT(1A)-receptor agonist 8-OH-DPAT (0.05 mg/kg subcutaneously) or antagonist NAN-190 (0.1 mg/kg intraperitoneally) for 14 days on anxious-depressive-like behavior of female rats during the key phases of the estrous cycle. Chronic administration of NAN-190 during the estrus phase produced an anxiogenic effect, while its administration during proestrus phase induced an anxiolytic effect. Administration of 8-OH-DPAT had no effect on anxiety level, but produced a pronounced antidepressive effect irrespective of the phase of the estrous cycle.


Assuntos
8-Hidroxi-2-(di-n-propilamino)tetralina/farmacologia , Transtornos de Ansiedade/metabolismo , Depressão/metabolismo , Ciclo Estral/fisiologia , Piperazinas/farmacologia , Antagonistas da Serotonina/farmacologia , Agonistas do Receptor de Serotonina/farmacologia , 8-Hidroxi-2-(di-n-propilamino)tetralina/administração & dosagem , Análise de Variância , Animais , Ciclo Estral/efeitos dos fármacos , Feminino , Aprendizagem em Labirinto/efeitos dos fármacos , Piperazinas/administração & dosagem , Ratos , Ratos Wistar , Antagonistas da Serotonina/administração & dosagem , Agonistas do Receptor de Serotonina/administração & dosagem
10.
Bull Exp Biol Med ; 141(4): 427-9, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17152362

RESUMO

The effect of chronic combined treatment with galantamine and 17beta-estradiol on passive avoidance retention was studied in middle-aged ovariectomized female rats (15 months) with scopolamine-induced amnesia. Combined treatment with galantamine and estradiol completely restored retrieval of memory traces in middle-aged ovariectomized female rats.


Assuntos
Amnésia/tratamento farmacológico , Estradiol/farmacologia , Galantamina/farmacologia , Memória/efeitos dos fármacos , Ovário/fisiologia , Animais , Estradiol/metabolismo , Estrogênios/deficiência , Feminino , Antagonistas Muscarínicos/farmacologia , Ovariectomia , Ratos , Escopolamina/farmacologia , Fatores de Tempo
11.
Bull Exp Biol Med ; 142(6): 700-2, 2006 Dec.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-17603674

RESUMO

The effects of chronic combined treatment with alpha7-nicotinic cholinergic receptor agonist RJR-2403 (1.0 mg/kg intraperitoneally) or alpha7-nicotinic cholinergic receptor antagonist mecamylamine (1.0 mg/kg intraperitoneally) and 17beta-estradiol (0.5 microg per rat intramuscularly) for 10 days on passive avoidance retention were studied in middle-aged (15 months) ovariectomized rats with experimental Alzheimer type dementia. Chronic treatment with RJR-2403 and 17beta-estradiol had a pronounced antiamnestic effect under conditions of Alzheimer type dementia in middle-aged ovariectomized rats.


Assuntos
Doença de Alzheimer/complicações , Amnésia/tratamento farmacológico , Nicotina/análogos & derivados , Agonistas Nicotínicos/farmacologia , Receptores Nicotínicos/efeitos dos fármacos , Acetilcolina/farmacologia , Doença de Alzheimer/tratamento farmacológico , Amnésia/induzido quimicamente , Animais , Aprendizagem da Esquiva/efeitos dos fármacos , Quimioterapia Combinada , Estradiol/uso terapêutico , Feminino , Mecamilamina/uso terapêutico , Nicotina/farmacologia , Nicotina/uso terapêutico , Ovariectomia , Ratos , Ratos Wistar , Receptores Nicotínicos/fisiologia
12.
Bull Exp Biol Med ; 142(1): 80-2, 2006 Jul.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-17369909

RESUMO

Chronic combined administration of 5-HT1A receptor antagonist NAN-190 and 17beta-estradiol improved conditioned passive avoidance performance in middle-aged ovariectomized rats with scopolamine-induced amnesia. Our results suggest that the ovarian hormonal, cholinergic, and serotoninergic systems play a role in age-related cognitive disturbances under conditions of hypoestrogenic syndrome.


Assuntos
Amnésia/induzido quimicamente , Amnésia/tratamento farmacológico , Estradiol/uso terapêutico , Piperazinas/uso terapêutico , Escopolamina/efeitos adversos , Análise de Variância , Animais , Combinação de Medicamentos , Feminino , Ovariectomia , Ratos , Ratos Wistar
13.
Bull Exp Biol Med ; 138(1): 54-7, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15514723

RESUMO

We studied the effect of repeated intraperitoneal treatment with dehydroepiandrosterone in doses of 0.1 and 0.7 mg/kg on conditioned-response activity and behavior of adult male rats. The effect of dehydroepiandrosterone on learning was estimated in conditioned active and passive avoidance response paradigms. Chronic administration of dehydroepiandrosterone in low and high doses had no effect on retention of conditioned passive avoidance response in adult male rats 24 h after learning. However, chronic administration of dehydroepiandrosterone in low dose impaired acquisition of the conditioned active avoidance response. It should be emphasized that chronic administration of dehydroepiandrosterone in high dose did not modulate acquisition and retention of this reaction.


Assuntos
Aprendizagem da Esquiva/efeitos dos fármacos , Comportamento Animal/efeitos dos fármacos , Condicionamento Clássico/efeitos dos fármacos , Desidroepiandrosterona/farmacologia , Memória/efeitos dos fármacos , Animais , Animais não Endogâmicos , Masculino , Ratos
14.
Bull Exp Biol Med ; 137(1): 43-6, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-15085243

RESUMO

Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17beta-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded. Administration of 8-OH-DPAT to ovariectomized female rats increased the number of entries into open arms of the maze and the time spent there. Combination treatment of ovariectomized animals with 8-OH-DPAT and 17beta-estradiol decreased total locomotor and emotional activity in the open field. Administration of 8-OH-DPAT alone or in combination with 17beta-estradiol improved performance of the conditioned passive avoidance response.


Assuntos
8-Hidroxi-2-(di-n-propilamino)tetralina/farmacologia , Comportamento Animal/efeitos dos fármacos , Agonistas do Receptor de Serotonina/farmacologia , Animais , Estradiol/farmacologia , Feminino , Ovariectomia , Ratos , Serotonina/metabolismo
15.
Neurosci Behav Physiol ; 32(3): 237-41, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12135335

RESUMO

The effects of L-tryptophan on conditioned reflex learning and behavior were studied in male rats with deficient and excess thyroid hormones levels. The learning process was studied using a model consisting of a conditioned active avoidance response; animal behavior was assessed in an open field test. These studies showed that in conditions of thyroid hormone deficiency. L-tryptophan had positive effects on the acquisition and reproduction of the active avoidance reflex, restoring the ability of the animals to learn actively; L-tryptophan increased investigative activity in the open field test. In conditions of increased thyroid hormone levels, L-tryptophan reversed the mild stimulating effects of thyroid hormones on the processes of developing and performing the active avoidance habit, and increased investigative activity, but decreased the amount of grooming.


Assuntos
Comportamento Animal/efeitos dos fármacos , Condicionamento Operante/efeitos dos fármacos , Hipertireoidismo/psicologia , Hipotireoidismo/psicologia , Aprendizagem/efeitos dos fármacos , Triptofano/farmacologia , Animais , Aprendizagem da Esquiva/efeitos dos fármacos , Hipotálamo/efeitos dos fármacos , Hipotálamo/metabolismo , Masculino , Ratos , Serotonina/metabolismo , Tireoidectomia , Tri-Iodotironina/farmacologia
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