RESUMO
The paper presents the results of a study of iron metabolism in 185 patients with cirrhosis of different etiologies. The frequency of iron deficiency in 28.6% of patients and the syndrome of iron overload - 18.9%. The gender and etiology of cirrhosis role in the frequency of occurrence of the syndrome of iron overload and iron deficiency. The iron metabolism disorders in relationship with the frequency of complicated cirrhosis, the severity of liver cirrhosis, according to Child-Pugh's grade of severity of liver disease, the severity of cytolytic syndrome.
Assuntos
Sobrecarga de Ferro/epidemiologia , Sobrecarga de Ferro/etiologia , Cirrose Hepática/complicações , Cirrose Hepática/epidemiologia , Adulto , Feminino , Humanos , Sobrecarga de Ferro/sangue , Cirrose Hepática/sangue , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Índice de Gravidade de Doença , SíndromeRESUMO
The pharmacokinetics of iron oral medication in was studied in patients with liver cirhorosis. In patients with hepatocellular insufficiency and high level of gepsidin found a decrease of the iron absorption constant, which led to a change in pharmacokinetic parameters. Tests on the absorption of iron have been conducted in 25 patients with liver cirrhosis, 36% of them showed a decrease of iron absorption, which led to the decrease in the efficiency of subsequent iron therapy. Found that elevated levels of gepsidin that lead to violation of iron metabolism and absorption and reduce the effectiveness of the treatment of iron deficiency.
