[Periodontal function and nonspecific resistance in the dynamics of experimental hypo- and hyperthyroidism]. / Sostoianie parodonta i nespetsificheskoi rezistentnosti v dinamike éksperimental'nogo gipo- i gipertireoza.

Morphologic study of white rat periodontal tissue and assessment of nonspecific resistance of the body by whole blood antibacterial activity, skin bactericidal activity, blood serum and mixed salivary lysozyme activity were carried out over the course of experimental hypo- and hyperthyrosis starting from day 5 to day 90. The detected pathologic changes in the periodontium were in line with the time course of nonspecific resistance of the body. In hypothyrosis an earlier depression of nonspecific resistance factors was parallelled by earlier and more marked inflammatory destructive processes in the rat periodontium as compared to that in hyperthyrosis.

[Changes in integral indicators of natural immunity in experimental hypo- and hyperthyroidism]. / Dinamika integral'nykh pokazatelei estestvennogo immuniteta pri éksperimental'nom gipo- i gipertireoze.

Two natural immunity integral indices-the skin bactericidal action and the blood antibacterial activity-were studied in experimental rat hypo- and hyperthyrosis by means of original radioimmunoassay. A decrease in the skin bactericidal action was seen hypothyrosis, but as whole, this test proved to be insufficiently sensitive. An alteration of the blood antibacterial activity in hypo- and hyperthyrosis is characterized by an initial increase in this activity, followed by its lowering. The prolonged phase of the blood antibacterial activity growth was found in hyperthyrosis, whereas in hypothyrosis the decreased phase of the above activity was seen. The pronounced changes in the natural immunity level precede clinical manifestations of the thyroid affection. Radioimmunoassay is recommended for studying the blood antibacterial activity as a sensitive and informative test, allowing one to judge of the antibacterial immunity state.