Incremental validity of the comprehensive inventory of thriving in predicting self-reporting mental and physical health among community populations.

This study examined psychometric properties and 1-year predictive validity of the Comprehensive Inventory of Thriving in China. In total, 556 participants in Chinese communities completed the Comprehensive Inventory of Thriving for confirmatory factor analysis. The other 533 individuals further completed the Flourishing Scale and Satisfaction With Life Scale and reported their physical and mental health 1 year later. The 18-factor correlated model showed a better goodness-of-fit than the seven-factor second-order related model. Thriving had higher correlation coefficients with depression, anxiety, stress, and doctor visits. The Comprehensive Inventory of Thriving is an efficient screening tool to differentiate the risk group from other groups and can predict health outcomes among community populations for active interventions.

Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO.

Gastric ulcers (GUs) are common pathologies that affect many people around the world. Excessive alcohol consumption is one of the main causes of GUs; however, there are still lack of effective drugs for the prevention or therapy of GUs. In this study, we evaluated the protective effects and possible mechanisms of kaempferol (KAE) against acute ethanol-induced lesions to the gastric mucosa in mice. Fasted mice were orally given vehicle (0.9% saline), omeprazole (20 mg/kg), or KAE (40, 80, or 160 mg/kg) for 1 h in different experimental sets prior to the establishment of the GU model by challenge with absolute ethanol (10 ml/kg). Animals were euthanized 1 h after ethanol intake, and their plasma and stomach tissues were subject to further examination. Macroscopic and microscopic lesions, and immunological and biochemical parameters were observed. The effects of inflammation were investigated using the following indicators: tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), IL-6, myeloperoxidase (MPO), and nitric oxide (NO). Results showed that KAE significantly decreased the ulcer index, increased the preventive index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein. KAE decreased MPO activity and pro-inflammatory cytokine (TNF-α, and IL-1ß) levels, and improved NO levels. The gastroprotective activity of KAE might be attributed to the preservation of gastric mucous glycoproteins levels, thus by inhibiting neutrophil accumulation and MPO activity, adjusting the levels of pro-inflammatory cytokines, and improving NO production.