Comprehensive assessment of autonomic dysfunction in patients with asthma using the regulatory systems activity index.

The regulatory systems activity index (RSAI), proposed by RM Bayevsky, can be used as an integral measure of the functional stress of the autonomic nervous system in patients with asthma. RSAI values of 8-10 should be used as a criteria for maladaptive and prognostically unfavorable course of asthma. Autonomic dysfunction at these RSAI levels is characterized by a pronounced reduction in total power of the spectrum of heart rate variability (HRV) (TP<1000ms), significant predominance of humoral-metabolic waves (VLF> 65%), increased activity of the sympathetic nervous system(LF/HF> 3.0), and high index of centralization (IC > 8).

[CORRECTION OF HEART RATE VARIABILITY USING DIAPHRAGMATIC BREATHING MODE BIOFEEDBACK IN HEALTHY PEOPLE.]

The research is an attempt to explain the use of portable computer devices aiming to correct heart rate variability (HRV) of healthy young men. According to the data, used deep diaphragmatic breathing in mode of biofeedback harmonizes breathing and blood circulation which positively affects the body's adaptive potential. However, developers present the portable instruments of biofeedback primarily as a means of psychological relaxation. The aim of this study is to determine whether such devices are able to significantly affect heart rate variability and how long this effect lasts. There were 30 males aged 18 to 20 years that participated in this study. They were randomly divided into three equal groups with up to 10 people in each of them. Members of the first group were doing breathing exercises using a portable biofeedback StressEraser device, the second group used Em-Wave2, and the third one used hardware and software system MyCalmBeat. Each session lasted from 10 to 15 minutes. There were 10 sessions held daily in the morning. HRV was recorded by remote heart rate monitor Polar RS800CX and software Polar ProTrainer5. 5-minutes' stationary segments of the curve chest electrocardiogram removal were used in order to calculate the HRV indexes. It was found that 15 minutes deep breathing in mode of biofeedback significantly affects the heart rate variability of healthy young people. In particular, it increases the overall heart rate variability according to the statistical and spectral analysis. It was established that in all 3 groups of experiment participants the spectral curve low-range "Low frequency" (LF) suffered the major shifts. These shifts reflect the activity level of the sympathetic autonomic nervous system (ANS) as well as vascular-motor center according to the conventional interpretation. It was found that all three groups suffered a specific weight decrease of Very Low Frequency (VLF)% respectively 11.8±2.2%;(p <0,01); 6.6 ± 2.8%; (p <0,02) and 6.8 ± 2.4% (p <0,05). This means that activity redistribution between different regulatory components of heart rate occurred in favour of the peripheral ANS parts. Heart rate variability changes of this kind remained valid for at least one month after the experiment. The greatest influence on heart rate variability was observed in the group of people who used the device StressEraser.

[Relationship between human emotional status and parameters of central hemodynamics during physical and psychological stress]. / Vzaiemozviazok emotsiinoho stanu liudyny z reaktsiieiu tsentral'noï hemodynamiky pry fizychnykh i psykhichnykh navantazhenniakh.

Changes in central hemodynamics (CHD) to postural changes, psychoemotional stress (mental arithmetic subtraction test) and combined isometric and psychoemotional stress were studied in 21 healthy males aged 18-23, and correlation between CHD parameters and 23 psyhoemotional traits was determined. Negative correlation of the arterial pressure level with parametres of physical aggression, the total level of aggression, and rigidity, as well as its positive correlation with the excitation processes in cerebral cortex have been found. Cardiac output index just after postural loading and at the combined stress correlated with sense of fault. Heart rate at isometric loading correlated with the sense of fault, either. Thus, the arterial pressure is the parameter of CHD that correlates with the human psychoemotional status most closely.

[Role of myocardial micropump function in the pathogenesis of ischemic heart disease]. / Ob uchastii mikronasosnoi funktsii miokarda v patogeneze ishemicheskoi bolezni serdtsa.

Myocardial vibrational activity examined in 40 patients with functional classes II-III coronary heart disease and in 20 apparently healthy individuals, which indirectly reflects the status of its micropump function has been studied by using a spectral analysis of the first heart sound. Inhibition of the micropump function of the myocardium with its higher oxygen demands has been found to substantially contribute to the pathogenesis of myocardial ischemia.

[Application of biomechanical stimulation of lower extremity muscles in the treatment of patients with hypertension]. / Ispolzovanie biomekhanicheskoi stimuliatsii myshts nizhnikh konechnostei v lechenii bolnykh gipertonicheskoi bolezníu.

The impact of biomechanical stimulation of lower extremity muscles was studied in patients with essential hypertension on systemic blood pressure and its hemodynamic components. A short-term (10-15-minute) antihypertensive effect was found in a 2-minute stimulation session. Inclusion of biomechanical stimulation into the multimodality treatment of patients with Stage II hypertensive disease will enhance its efficiency. The mechanism responsible for the depressive effects of biomechanical stimulation and the role of the hemodynamic pump function of skeletal muscles in this process are discussed in the paper.