RESUMO
The hippocampus has been the target of stem cell transplantations in preclinical studies focused on Alzheimer's disease, with results showing improvements in histological and behavioral outcomes. The corpus callosum is another structure that is affected early in Alzheimer's disease. Therefore, we hypothesize that this structure is a novel target for human neural stem cell transplantation in transgenic Alzheimer's disease mouse models. This study demonstrates the feasibility of targeting the corpus callosum and identifies an effective immunosuppression regimen for transplanted neural stem cell survival. These results support further preclinical development of the corpus callosum as a therapeutic target in Alzheimer's disease.
RESUMO
Advances in surgical and anesthetic techniques, combined with sophisticated perioperative assessment, are factors that have contributed to an expanding number of older adults undergoing oral and maxillofacial surgery. Clinical competency and ability to evaluate carefully the pathophysiologic risk of comorbid disease become paramount in order to provide safe, expedient, and effective surgical care. This review article attempts to focus on the importance of perioperative risk assessment in geriatric surgical patients. Specifically, medical workup of comorbid systemic illnesses and pharmacologic therapy are assessed in order to determine appropriate treatment strategies for successful surgical outcomes.
