1.
Org Lett
; 26(15): 3109-3113, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38552168
RESUMO
Alkynes are readily available and multifunctional synthetic intermediates, but their 1,1-oxofunctionalization remains challenging. Herein, we report a 1,1-oxycarbonation of terminal alkynes to construct ketones through sequential borylation, 1,2-carbon migration, and oxidation with Oxone as the proton source and oxidant. The synthetic potential of this transformation is showcased by the broad functional groups, scale-up synthesis, and diverse product transformations.