[Anatomo-clinical observations of the splenic reaction (splenomegaly) occuring in fulminant-comatose forms of acute viral hepatitis]. / Observatii anatomo-clinice asupra reactiei splenice (splenomegaliei) in formele fulminant-comatoase de hepatite virale acute.

Statistical analysis of 80 cases of fulminant-comatose forms of acute viral hepatitis revealed a frequency of 13.7% of splenic hypertrophy as compared to a frequency of 50.6% in 87 common forms of illness. The intensity and frequency of the splenic reaction in the two studied series shows an agreement between the data of the clinical examination--splenic palpability--and the anatomo-pathological ones--splenic weight in grams at necropsy being in inverse ratio to aging. Thus, between the prognostical benignity of the fulminant-comatose forms and the intensity of the splenic reaction appears to be a direct relation.

Sickle-cell disease. Two cases in a Romanian family.

Hemoglobin S is rarely found in Caucasians, especially in its homozygous expression. The authors report two cases of homozygotes for Hb S diagnosed in a Romanian family. Ten subjects were investigated, belonging to three generations of the same family, and the following results were obtained: two cases of homozygotes for Hb S; five cases of heterozygotes; three normal subjects. One of the two subjects homozygous for Hb S, a girl aged six, had a severe clinical evolution, typical for homozygous drepanocytosis. The second case, a sister of the first aged two, had a less severe evolution, without splenomegaly and thrombotic accidents. The heterozygote subjects showed no clinical symptoms. The two cases of homozygous Hb S reported are the first cases of sickle-cell disease described in Romania.