RESUMO
A 37-year-old patient with systemic lupus erythematosus, who had been treated with oral corticosteroids for 10 years, developed primary cutaneous nocardiosis. Brown-violaceous, suppurative nodules and plaques arose on her right leg. Cultures of multiple biopsies on blood agar medium grew Nocardia. The patient received 500 mg of imipenem three times a day which resulted in complete regression of the lesions within two months. No relapse was observed 6 months later.
Assuntos
Lúpus Eritematoso Sistêmico/complicações , Nocardiose/diagnóstico , Nocardia asteroides/isolamento & purificação , Infecções Oportunistas/diagnóstico , Dermatopatias Bacterianas/diagnóstico , Adulto , Feminino , Seguimentos , Humanos , Imipenem/administração & dosagem , Nocardiose/tratamento farmacológico , Nocardiose/etiologia , Infecções Oportunistas/tratamento farmacológico , Infecções Oportunistas/etiologia , Dermatopatias Bacterianas/complicações , Dermatopatias Bacterianas/tratamento farmacológico , Tienamicinas/administração & dosagem , Resultado do TratamentoRESUMO
Our study concerns contact sensitization in children, the frequency of which is still debated in the literature, even though specific reports are increasing. During a 7 year period (1988-1994) 670 patients, 6 months to 12 years of age, were patch tested with the European standard series, integrated with 24 haptens, at the same concentrations as for adults. We observed positive results in 42% of our patients. Thimerosal, nickel sulfate, Kathon CG, fragrance mix, neomycin, wool alcohols, and ammoniated mercury induced most of the positive responses. The highest sensitization rate was found in children from 0 to 3 years of age. Comments on main positive haptens are reported. Seventy-seven percent of our sensitized patients were atopics, suggesting that atopy represents a predisposing factor for contact hypersensitivity. Patch testing represents a useful diagnostic procedure for the definition of childhood eczematous dermatitis and for the identification of agents inducing contact sensitization which is frequently associated with atopic dermatitis.
Assuntos
Dermatite Alérgica de Contato/diagnóstico , Eczema/etiologia , Criança , Pré-Escolar , Dermatite Alérgica de Contato/complicações , Dermatite Atópica/diagnóstico , Feminino , Humanos , Lactente , Masculino , Testes do Emplastro/métodosRESUMO
Reactive dyes are used especially for colouring natural fibres (cotton, silk and wool) that are widely used in Western countries, particularly Italy, in the production of clothes. The aim of our study was to investigate sensitization to the most commonly used reactive textile dyes in patients undergoing patch tests, and to assess the clinical relevance of contact sensitization to these dyes. 1813 consecutive patients underwent patch tests with the GIRDCA standard series and an additional textile series of 12 reactive dyes. 18 of these patients were sensitized to reactive dyes (0.99%) (4 only to reactive dyes). The dyes most frequently responsible for positive patch tests were Red Cibacron CR and Violet Remazol 5R (respectively, 8 and 5 positivities). In 5 cases only was a history of intolerance to particular garments given; of 4 patch tests performed with pieces of garment, 2 were positive. In 1 occupationally-exposed patient, airborne contact dermatitis was suspected. Owing to the lack of up-to-date patch test series, some cases of allergic contact dermatitis from textile dyes are probably misdiagnosed: new colouring agents are continuously introduced to the market, so that a close relationship with textile industry is necessary to improve our diagnostic tools.
