Predictive factors of Sexual Quality of Life in women with polycystic ovary syndrome: a path analysis.

Polycystic ovarian syndrome (PCOS) is one of the common endocrine disorders. This study aimed to assess predictive factors of sexual quality of life among Iranian women with PCOS. A cross-sectional study was conducted on 100 women with PCOS in Hamadan, Iran, from July to October 2021. Data was collected using The Sexual Quality of Life-Female (SQOL-F) questionnaire, The Hurlbert Index of Sexual Compatibility, hirsutism, and a general health questionnaire (GHQ-28). Data were analyzed using descriptive statistics, Bivariate Pearson correlations, and a path model by the SPSS, Version 16, and LISREL software version 8.5. The average age of participants was 32.80 years. The mean (SD) of the total SQOL-F, sexual compatibility, and GHQ were 69.36 (18.78), 55.44 (7.07), and 58.06 (12.87), respectively. Our results showed that hirsutism score, GHQ, and sexual compatibility were the main predictors of the SQOL-F. Sexual compatibility has an indirect effect on the SQOL-F through the GHQ. The findings of the present study suggest that women with PCOS should be routinely screened for sexual quality of life by qualified health professionals. In addition, the necessary medical interventions and counseling should be done for improving sexual compatibility, mental health, and clinical manifestation of these women.

The Effective Factors on The Sexual Function of Polycystic Ovary Syndrome Women: A Cross-Sectional Study.

BACKGROUND: One of the most common endocrine disorders in women during reproductive age is polycystic ovary
syndrome (PCOS). This study aimed to evaluate sexual functioning among women with PCOS in a sample of a region's
population in the west of Iran.
Materials and Methods: This study was a cross-sectional study that was conducted on 130 women with PCOS who
referred to three clinics of gynecology, infertility, and dermatology affiliated with Hamadan University of Medical
Sciences, Iran, from September to November 2020. The measurement tools included demographic characteristics,
hirsutism score, and sexual function was assessed using the female sexual function index (FSFI) questionnaire.
Results: In total, 60% of patients had reported sexual dysfunction related to lubrication, satisfaction, and pain as domains
of sexual dysfunction. The number 109 (83.85%) of them had hirsutism and these patients had a lower score for
lubrication (3.7 ± 1.47 vs. 4.47 ± 1.71, P=0.03), orgasm (3.2 ± 1.34 vs. 3.95 ± 1.37, P=0.02), satisfaction (3.4 ± 1.29
vs. 3.71 ± 1.33, P=0.03), and FSFI score (22.56 ± 5.78 vs. 25.42 ± 5.51, P=0.04). Women with higher education had
reported higher scores of FSFI and its domains. Rural participants had a higher arousal score (3.93 ± 1.4 vs. 3.37 ±
1.28, P=0.04). Moreover, housekeeper women had higher scores regarding desire, pain, and total FSFI score.
Conclusion: Our results showed that there was a significant association between hirsutism and FSFI scores, different
domains, including lubrication, orgasm, and satisfaction.

Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?

BACKGROUND: There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. PURPOSE: This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. METHODS: All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. RESULTS: All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 casecontrol studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90-1.35) and (RR, 1.10; 95% CI, 0.96-1.24). CONCLUSIONS: The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.

The effect of bee prepolis on primary dysmenorrhea: a randomized clinical trial.

OBJECTIVE: Primary dysmenorrhea typically occurs with no associated pelvic pathology and is common in adolescents and young women. This study evaluated the effect of bee propolis on relief of primary dysmenorrhea. METHODS: The study was performed in 2018 in Hamadan, in western Iran, among female students with primary dysmenorrhea. Participants were randomly divided into two groups, using balanced block randomization, and were administered a placebo or bee propolis capsules for 5 days during two menstruation cycles. The number of participants required was estimated to be 86 in total, with 43 students in each group according to the inclusion criteria. We used the visual analog scale to assess pain severity. The independent t-test was conducted for comparing between two groups, using SPSS 16.0. RESULTS: A significant change was found in the mean pain scores during the first (P<0.001) and second (P<0.001) months after using bee propolis in comparison with placebo. The means of the pain scores in the bee propolis group were 5.32±2.28 and 4.74±2.40 in first and second months after the intervention, respectively, whereas the means of the pain scores in the placebo group were 7.40±1.21 and 7.17±1.24 in first and second months after the intervention, respectively. CONCLUSION: Our study showed that the use of bee propolis for two months compared with placebo reduced primary dysmenorrhea during the first and second months after use, with no adverse effects. Therefore, it could be used as an alternative to nonsteroidal anti-inflammatory drugs for relief of primary dysmenorrhea.

The uterine leiomyoma and placenta previa: a meta-analysis.

Background: Some epidemiological studies have reported that uterine leiomyoma may increase the risk of placenta previa. To date, the meta-analysis has not been carried out for assessing the relationship between uterine leiomyoma and placenta previa. This meta-analysis was carried out to estimate the association between uterine leiomyoma and the risk of placenta previa. Methods: A systematic search was conducted out in major databases PubMed, Web of Science, and Scopus from the earliest possible year to June 2017. The heterogeneity across studies was explored by Q-test and I2 statistic. The publication bias was assessed by Begg's and Egger's tests. The results were showed using odds ratio (OR) estimate with its 95% confidence intervals (CI) using a random-effects model. Results: The literature search included 1218 articles until to June 2017 with 255,886 women. Based on OR estimates obtained from case-control and cohort studies, there was significant association between uterine leiomyoma and placenta previa in studies adjusted (2.21; 95%CI: 1.48, 2.94). Conclusions: We showed based on reports in observational studies that uterine leiomyoma is a risk factor for placenta previa in studies adjusted.

Polycystic ovary syndrome and its impact on Iranian women's quality of life: a population-based study.

BACKGROUND: Polycystic ovary syndrome (PCOS) is a major public health concern worldwide affecting up to one in five women at reproductive age. It is associated with biochemical and hormonal disturbances as well as adverse cosmetic, reproductive, metabolic, and psychological consequences, resulting in worsened quality of life. The aim of the present study is evaluating the quality of life and determining its degrading factors among Iranian women suffering from this syndrome. METHODS: This cross-sectional study was conducted on 200 PCOS women in Hamadan, Iran. In order to measure quality of life we used the Persian version of Health-related Quality of Life Questionnaire for PCOS (PCOSQ). Descriptive statistics was used to explore the data. In addition linear regression analysis was performed to assess factors affecting health-related quality of life in this population. RESULTS: The mean score for quality of life domains (from the greatest to the least serious concern) were: infertility (3.43 ± 1.63), emotions (3.55 ± 1.17), menstrual problems (3.77 ± 1.36), body hair (3.80 ± 2.05) and weight (4.32 ± 1.80), respectively. The higher score represents better function. However, multivariate analysis revealed that hirsutism had the strongest impact on the patients' quality of life (p < 0.001) followed by infertility (p = 0.038) and menstrual irregularity (p = 0.003). CONCLUSION: The findings showed that impairment of quality of life was associated with PCOS related conditions such as hirsutism, infertility and menstrual problems.

Measures of health-related quality of life in PCOS women: a systematic review.

INTRODUCTION: Polycystic ovary syndrome (PCOS) is associated with biochemical and hormonal disturbance and adverse cosmetic, reproductive, metabolic, and psychological consequences, resulting in reduced health-related quality of life (HRQoL). Various generic and specific questionnaires have been used for assessing different dimensions of HRQoL in PCOS women. The purpose of this systematic review was to identify those general and specific instruments and to determine the factors that affect HRQoL in PCOS women. MATERIALS AND METHODS: The research strategy involved general and specific terms in relation to PCOS women and their QoL. A review was performed on studies that were published between 1945 to 2017 and that were indexed in MEDLINE, ISI Web of Science, and Scopus. A narrative synthesis of the data was provided. RESULTS: In total, 52 studies (9 qualitative and 43 quantitative) were included in the review. The analysis indicated that 3 specific and 5 general instruments were used to measure the QoL in PCOS women. Of these, the 36-Item Short Form Health Survey (SF-36) and the Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (PCOSQ) were used most frequently. All studies assessed different aspects of QoL in PCOS women and found that PCOS had negative effects on QoL in this population. CONCLUSION: The PCOSQ and the SF-36 were used most frequently for the assessment of QoL in PCOS women. Perhaps using either a specific questionnaire solely or a specific questionnaire in conjunction with a generic measure would be more appropriate when measuring QoL in PCOS women. However, both questionnaires showed that they are able to capture different aspects of QoL in PCOS women and to identify areas that can help to improve QoL in these women.

The association of placenta previa and assisted reproductive techniques: a meta-analysis.

BACKGROUND: Several epidemiological studies have determined that assisted reproductive techniques (ART) can increase the risk of placenta previa. To date, only a meta-analysis has been performed for assessing the relationship between placenta previa and ART. This meta-analysis was conducted to estimate the association between placenta previa and ART in singleton and twin pregnancies. METHODS: A literature search was performed in major databases PubMed, Web of Science, and Scopus from the earliest possible year to April 2017. The heterogeneity across studies was explored by Q-test and I2 statistic. The publication bias was assessed using Begg's and Egger's tests. The results were reported using odds ratio (OR) and relative risk (RR) estimates with its 95% confidence intervals (CI) using a random-effects model. RESULTS: The literature search yielded 1529 publications until September 2016 with 1,388,592 participants. The overall estimate of OR was 2.67 (95%CI: 2.01, 3.34) and RR was 3.62 (95%CI: 0.21, 7.03) based on singleton pregnancies. The overall estimate of OR was 1.50 (95%CI: 1.26, 1.74) based on twin pregnancies. CONCLUSIONS: We showed based on odds ratio reports in observational studies that ART procedures are a risk factor for placenta previa.

The association between maternal smoking and hyperemesis gravidarum: a meta-analysis.

BACKGROUND: The majority of studies have not found hyperemesis to be a protective and some others have not. To date, no meta-analysis has quantitatively assessed the association between smoking and risk of hyperemesis gravidarum. To help close that research gap, we performed meta-analysis of the association between smoking and risk of hyperemesis gravidarum. METHODS: A literature search was carried out in PubMed, Web of Science, and Scopus from the earliest possible year to January 2016. The heterogeneity across studies was explored by Q-test and I2 statistic. The possibility of publication bias was assessed using Begg's and Egger's tests. The results were reported using odds ratio (OR) estimate with its 95% confidence intervals (CI) using a random-effects model. RESULTS: The literature search yielded 607 publications until January 2016 with 1 400 000 participants. Based on the random-effects model, compared to nonsmoker people, the estimated OR of hyperemesis gravidarum was 0.40 (95% CI: 0.24, 0.56). CONCLUSIONS: We showed based on reports in epidemiological studies that smoking before and during pregnancy is not a risk factor for hyperemesis gravidarum but also can reduce the risk of it.

The use of omega 3 on pregnancy outcomes: a single-center study.

OBJECTIVE: To investigate the rate of Omega 3 use in pregnant women and its effect on pregnancy outcome. METHODS: The study was conducted from January to April 2010 at Tamin Ejtemaee Hospital, Hamedan, Iran, and comprised women who were carrying 16 weeks of pregnancy and were referred to the study site. They were divided into 3 groups: those who did not consume fish in a month, those who consumed fish 1-3 times in the preceding month, and those who had it more than 3 times in the same period. Data was analysed using SPSS version 16. RESULTS: Of the 550 subjects initially approached, 20(3.6%) either declined to participate or were lost to follow-up. The final study sample, as such, comprised 530(96.4%) who were followed up until delivery. The overall mean age of the subjects was 27.98+/-5.30 years. Of the total, 21(4%) were below 18 years, 467(88%) were between 18-35 years, and 42(8%) were over 35 years of age. Omega 3 consumption was significantly associated with neonate weight (p<0.03), pre-eclampsia (p<0.04) and pre-term labour (p<0.01). CONCLUSION: Increased consumption of omega 3 can prevent low birth weight, pre-term labour and pre-eclampsia.