RESUMO
BACKGROUND: Cystic nephroma (CN) and pleuropulmonary blastoma (PPB) are rare tumors without any previously recognized familial association. METHODS: Two cases of CN and one case of PPB in three siblings are reported. RESULTS: A 27-month-old girl and a 31-month-old boy underwent nephrectomy for CN and are free of disease in the contralateral kidney 16 and 14 years later, respectively. Their 28-month-old sister underwent pleuropneumonectomy with postoperative chemotherapy for PPB and died of recurrent disease 9 months later. CONCLUSION: To the knowledge of the authors, these cases represent the first reported familial occurrence of CN and the second of CN and PPB among siblings. The inheritance of a germline mutation predisposing to the development of these tumors is postulated.
Assuntos
Neoplasias Renais/genética , Neoplasias Pulmonares/genética , Neoplasias Embrionárias de Células Germinativas/genética , Neoplasias Pleurais/genética , Tumor de Wilms/genética , Pré-Escolar , Feminino , Humanos , Lactente , Neoplasias Renais/patologia , Neoplasias Pulmonares/patologia , Masculino , Neoplasias Embrionárias de Células Germinativas/patologia , Neoplasias Pleurais/patologia , Tumor de Wilms/patologiaRESUMO
The clinical and pathologic features of a case of giant sclerosing leiomyoma of the bladder in a male Polynesian patient are reported. The presenting complication of chronic renal failure due to tumor envelopment of both ureters and consequent bilateral renal obstruction appears to be unique in the literature.
Assuntos
Falência Renal Crônica/etiologia , Leiomioma/complicações , Obstrução Ureteral/etiologia , Neoplasias da Bexiga Urinária/complicações , Adulto , Humanos , Leiomioma/patologia , Masculino , Esclerose , Neoplasias da Bexiga Urinária/patologiaRESUMO
Levels of volatile N-nitrosamines were measured in 10 brands of latex and 2 brands of silicone catheters using high performance liquid chromatography. The cytotoxicity of catheters from identical batches was determined by measuring the inhibitory effect of catheter extracts on the uptake of 3H-labelled thymidine into L-929 fibroblasts in culture (IC50). The most frequently encountered nitrosamines were N-nitrosodi-n-butylamine and N-nitrosodiethylamine. Total N-nitrosamine levels in excess of 100 ng/g were found in 6 of the 16 catheters tested. When compared with the cytotoxicity of the catheters a significant correlation was found, with increasing nitrosamine content being associated with greater cytotoxicity. In view of the reported toxic and carcinogenic effects of these compounds it is suggested that the nitrosamine content of catheters be routinely monitored and safe regulatory limits be imposed.
Assuntos
Nitrosaminas/análise , Cateterismo Urinário/instrumentação , Células Cultivadas , Cromatografia Líquida de Alta Pressão , Dietilnitrosamina/análise , Humanos , Nitrosaminas/toxicidade , Borracha/análiseRESUMO
A controlled randomised prospective study has been carried out on 100 male patients to compare the incidence of urethritis following catheterisation with either latex or silicone catheters. All patients underwent elective cardiac surgery and were catheterised for 48 h with antibiotic cover, and were followed up for 6 months post-operatively. Of those with latex catheters 22% developed urethritis, compared with 2% of those in the silicone catheter group. This difference is statistically significant (P less than 0.01). Two of the former patients developed a decreased urinary flow and both had tight anterior urethral strictures.
