RESUMO
A monocyclic "temple" synthetic lectin, with extended electron-rich aromatic surfaces, shows enhanced affinities for carbohydrates in water. The methoxy substituents favour binding to α-linked maltodextrins, against the all-equatorial substrates normally favoured by this family of receptors.
RESUMO
Phytochemical investigations of the n-butanol soluble sub-fraction of the methanolic extract of Galinsoga parviflora Cav. has led to the isolation of two new glucosides named as parvisides A (1) and B (2). Their structures have been assigned on the basis of their spectral analysis including 1D and 2D NMR techniques.
Assuntos
Asteraceae/química , Glucosídeos/química , Extratos Vegetais/química , Glucosídeos/isolamento & purificação , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Extratos Vegetais/isolamento & purificaçãoRESUMO
Galinosoates A-C (1-3), new aromatic esters, have been isolated from the n-hexane soluble fraction of Galinsoga parviflora. Their structures were assigned from the spectral data including IR, HR-EI-MS, 1D and 2D NMR.
Assuntos
Asteraceae/química , Derivados de Benzeno/isolamento & purificação , Derivados de Benzeno/química , Ésteres , Hexanos , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , PaquistãoRESUMO
Phytochemical investigation of the ethyl acetate soluble fraction of the methanol soluble extract of the roots of Daphne oleoides resulted in isolation and identification of two new isomeric biisoflavonoids characterized as 8,8"-bi-6-hydroxyorobol (1) and 8,8"-bi-6, 2'-dihydroxygenistein (2). The structures of these compounds were established by analysis of their 1D and 2D NMR and HRMS data.
Assuntos
Daphne/química , Flavonoides/química , Isoflavonas/química , Raízes de Plantas/química , Cromatografia Líquida de Alta Pressão , Indicadores e Reagentes , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Extratos Vegetais/química , Espectrometria de Massas de Bombardeamento Rápido de Átomos , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
Galinsosides A (1) and B (2), new flavanone glucosides together with two known flavanones, 7,3',4'-trihydroxyflavanone (3) and 3,5,7,3',4'-pentahydroxyflavanone (4) have been isolated from an ethyl acetate- soluble fraction of Galinsoga parviflora. Their structures were assigned on the basis of spectral studies. Compound 1 showed significant antioxidant and urease inhibitory activity while compound 2 was moderately active. On the other hand, 2 showed inhibitory potential against alpha-glucosidase.
Assuntos
Asteraceae/química , Flavanonas , Glucosídeos , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Antioxidantes/química , Antioxidantes/farmacologia , Flavanonas/química , Flavanonas/farmacologia , Glucosídeos/química , Glucosídeos/farmacologia , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Estruturas Vegetais/química , Urease/antagonistas & inibidoresRESUMO
Silymins A (1) and B (2), the new pentacyclic triterpenes, have been isolated from ethyl acetate fraction of Silybum marianum and their structures assigned from 1H and 13C NMR spectra, DEPT and by 2D COSY, NOE and HMBC experiments.
Assuntos
Silybum marianum/química , Triterpenos/química , Ciclização , Hidrogênio , Espectroscopia de Ressonância Magnética/métodos , Padrões de Referência , Triterpenos/isolamento & purificaçãoRESUMO
Hyperinols A (1) and B (2) are new taraxastane type triterpenes which have been isolated from the chloroform soluble fraction of Hypericum oblongifolium and their structures elucidated on the basis of spectroscopic data. Both showed significant inhibitory activity against chymotrypsin enzyme.
Assuntos
Quimotripsina/antagonistas & inibidores , Hypericum/química , Triterpenos/farmacologia , Inibidores da Tripsina/farmacologia , Clorofórmio/química , Concentração Inibidora 50 , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Soluções/química , Triterpenos/química , Inibidores da Tripsina/químicaRESUMO
Marianine, the new lanostane triterpene (1) and marianosides A (2) and B (3) have been isolated from the whole plant of Silybum marianum. Their structures were elucidated on the basis of extensive analysis of their one dimensional and two dimensional nuclear magnetic resonance (1D, 2D-NMR) spectral data. All inhibited chymotrypsin in a concentration-dependent manner.
Assuntos
Asteraceae/química , Quimotripsina/antagonistas & inibidores , Glucosídeos/farmacologia , Triterpenos/farmacologia , Inibidores da Tripsina/farmacologia , Configuração de Carboidratos , Clorofórmio , Glucosídeos/isolamento & purificação , Hidrólise , Espectroscopia de Ressonância Magnética , Extratos Vegetais/química , Solventes , Espectrofotometria Infravermelho , Espectrofotometria Ultravioleta , Triterpenos/isolamento & purificação , Inibidores da Tripsina/isolamento & purificaçãoRESUMO
Haloxylines A (1) and B (2), new piperidine alkaloids, have been isolated from the chloroform soluble fraction of Haloxylon salicornicum and their structures elucidated by spectroscopic techniques including 2D-NMR. Both the compounds displayed antifungal and cholinesterase enzymes inhibitory potentials.
