RESUMO
BACKGROUND: Familial Combined Hyperlipidemia (FCH) is related to different metabolic disorders. The objective of this study was to evaluate the presence of alterations of hydrocarbonated metabolism and lipid profile together with inflammatory and adhesion molecules in subjects with FCH compared to controls. METHODS: 75 HFC patients and 75 healthy individuals were studied. Glucose, insulin, HOMA-IR index and lipid parameters, in addition to anti-oxidized LDL antibodies (Anti ox-LDL), small and dense LDL (sdLDL) and HDL subfractions, proinflammatory cytokines and adhesion molecules were measured. RESULTS: FCH patients showed higher levels of hydrocarbonated metabolism parameters, total cholesterol, triglycerides, LDLc, Apolipoprotein B and non-HDLc (pâ¯<â¯.001), and lower levels of HDLc (pâ¯<â¯.001) and Apolipoprotein AI (pâ¯<â¯.05) than controls. In addition, the inflammatory markers hsCRP, IL-6, IL-8, P-selectin, E-selectin and ICAM were all higher with (pâ¯<â¯.05) respect to controls. The increase of sdLDL was correlated with the presence of IR and IL-6 levels. Significant differences in diameter and percentage of phenotype B LDL, small HDL subfractions and Anti ox-LDL were also detected between patients and controls. CONCLUSIONS: The lipid characteristics of FCH are confirmed by IR and a low grade inflammatory state in patients, and are associated with the predominance of sdLDL and Anti ox-LDL.
Assuntos
Hiperlipidemia Familiar Combinada/complicações , Adulto , HDL-Colesterol/sangue , Feminino , Humanos , Hiperlipidemia Familiar Combinada/sangue , Inflamação/complicações , Masculino , FenótipoRESUMO
Se realizó un estudio observacional descriptivo con diseño transversal con el objetivo de determinar la prevalencia de la enfermedad de Alzheimer, así como factores asociados en pacientes mayores de 60 años en el área de salud del policlínico sur de Sancti-Spíritus durante los años 2005-2006, a través de la aplicación de una encuesta así como del test de Folstein y la escala de Hachinky; con un muestreo conglomerado monoetápico, efectuándose un examen mínimo a cada sujeto en el hogar. El 22,7 porciento de la muestra tenía deterioro cognitivo tipo Alzheimer y se encontraron con mayor relación a dicha enfermedad la edad, la baja escolaridad y la depresión, no así el hábito de fumar, la obesidad, el consumo de alcohol, los antecedentes familiares de demencia, el trauma craneoencefálico y el sexo aunque hubo un predominio de la representación femenina. La prevalencia de deterioro cognitivo tipo Alzheimer fue menor de un tercio(AU)
A descriptive observational study with cross design was made in order to determine the prevalence of Alzheimer's disease and associated factors in patients over 60 years in the health area of Sancti Spíritus South polyclinic during 2005-2006, through the application of a survey as well as Folstein test and Hachinky scale, with single-stage sampling conglomerate, being applied a minimum examination in each subject at home. 22.7% of the sample had cognitive impairment Alzheimer type and were found that age, low education and depression had a closer relation with this disease, not the cases of smoking, obesity, alcohol consumption, family history dementia, head trauma and sex although there was a predominance of female representation. The prevalence of cognitive impairment Alzheimer type was less than a third(AU)
