1.
Psychopharmacology (Berl)
; 93(1): 31-5, 1987.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3114812
RESUMO
Ten patients with Alzheimer's disease were treated with intravenous infusion of physostigmine for 2 h. The acute effects on cognitive function, regional cerebral blood flow, and EEG were compared to placebo (isotonic glucose) using a double-blind cross-over design. Physostigmine causes a limited improvement of psychomotor performance and EEG and an increase of blood flow in the most severely affected cortical areas, predominantly in an early phase of Alzheimer's disease.