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J Cutan Pathol ; 47(5): 431-438, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31859431

RESUMO

BACKGROUND: Granular cell tumors (GCTs) are uncommon mucocutaneous and soft tissue neoplasms with distinctive histopathologic appearance but controversial histogenesis. Herein, we report a variant of cutaneous GCT featuring extensive desmoplastic stroma which may result in diagnostic difficulties with mesenchymal proliferations, particularly a dermatofibroma. METHODS: Following a recent case of GCT with prominent stromal desmoplasia, we reviewed all cases diagnosed as GCT during the past 10 years accessioned at the dermatopathology unit in a tertiary university hospital. RESULTS: Three additional cases with a similar excessive connective tissue were identified out of a total of 49 GCTs. Cytoplasmic granularity was often subtle and focal, S100 expression was weak, and nuclei had a tendency to show spindling in tumor cells entrapped within the desmoplastic areas. Of note, nuclear spindling is one of the criteria used to diagnose an atypical/malignant GCT. CONCLUSION: We propose the term "desmoplastic GCT" for these tumors, which not only appropriately addresses the stromal changes but also raises an awareness of GCT being one of the cutaneous tumors which may show stromal desmoplasia. Differential diagnostic difficulties apart, awareness of this phenomenon is important so that desmoplasia and resultant spindling are not linked with potential aggressive behavior.


Assuntos
Biomarcadores Tumorais/metabolismo , Núcleo Celular/ultraestrutura , Tumor de Células Granulares/patologia , Neoplasias de Tecidos Moles/patologia , Adulto , Idoso , Antígenos CD/metabolismo , Antígenos de Diferenciação Mielomonocítica/metabolismo , Conscientização , Núcleo Celular/patologia , Diagnóstico Diferencial , Feminino , Seguimentos , Tumor de Células Granulares/metabolismo , Tumor de Células Granulares/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecido Fibroso/patologia , Prognóstico , Proteínas S100/metabolismo , Neoplasias Cutâneas/patologia , Resultado do Tratamento
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