Solid-state continuous time crystal in a polariton condensate with a built-in mechanical clock.

Time crystals (TCs) are many-body systems that display spontaneous breaking of time translation symmetry. We demonstrate a TC by using driven-dissipative condensates of microcavity exciton-polaritons, spontaneously formed from an incoherent particle bath. The TC phases are controlled by the power of a continuous-wave nonresonant optical drive exciting the condensate and the interaction with cavity phonons. Those phases are, for increasing power, Larmor-like precession of the condensate pseudo-spins-a signature of continuous TC; locking of the frequency of precession to self-sustained coherent phonons-stabilized TC; and doubling of TC's period by phonons-a discrete TC with continuous excitation. These results establish microcavity polaritons as a platform for the investigation of time-broken symmetry in nonhermitian systems.

Adaptación del modo de autoconcepto en usuarios con diabetes tipo 2 de una unidad de primer nivel / Adaptation of the self-concept mode in users with diabetes type 2 in a first level unit / Adaptação do modo de autoconceito em usuários com diabetes tipo 2 de uma unidade de primeiro nível

Objetivo Comparar el nivel de adaptación del autoconcepto (NAA) en las personas que viven con Diabetes mellitus tipo 2 (DT2), en dos escenarios de una unidad de primer nivel. Metodología Investigación descriptiva, correlacional, comparativa y transversal con muestreo por conveniencia; se conformó por adultos con DT2 que asisten a control mensual y al grupo de ayuda mutua (GAM) en una unidad de primer nivel. Se aplicó cédula de datos generales e instrumento Viveros03 (a=.85); se realizó valoración antropométrica y glucemia capilar. El análisis de datos fue con SPSS v. 20. La comprobación de hipótesis fue mediante Shapiro-Wilk, T-student y Ji cuadrada. Resultados Se trabajó con 50 sujetos, 25 del GAM (Grupo A) y 25 de control ambulatorio (Grupo B). El NAA del grupo A fue 60% integrado y del B fue de 68% compensatorio, con diferencia significativa entre ambos grupos (p=0.02). Los estímulos contextuales como control glucémico, años de diagnóstico y tratamiento no demostraron dependencia (p >.05), contrario a los antecedentes familiares con diabetes y pertenecer al GAM en donde sí hubo relación (p= <.05). Conclusión El NAA fue mejor en el GAM, la valoración positiva del autoconcepto tuvo un mayor impacto, así mismo en el GAM, los antecedentes familiares son estímulos contextuales que permiten la adaptación de manera positiva.

Objective To compare the level of Adaptation of the Self-Concept (ASC) in persons suffering from Diabetes mellitus type 2 (DT2) in two locations at a first level unit. Methodology This is a descriptive, correlational, comparative, and transversal research with a sample by convenience of adults with DT2 attending to a monthly control, and to a Mutual Support Group MSG, both in a first level unit. The general data register and the Viveros03 instrument (a =.85) were used. Anthropometric and capillary glycemic level assessments were performed. Data were analyzed through SPSS v.20. The hypothesis was verified using Shapiro-Wilk, T-student and Chi square tests. Results There were 50 participants, the 25 in the MSG were assigned to group A, while the other 25 constituted the ambulatory and group B. ASC in group A was 60% while 68% in group B; the difference was significant at p = 0.002. Contextual stimuli such as capillary glycemic level, and years of diagnosis and treatment did not show dependence (p > .05) contrary to family diabetes background, and belonging to the MSG, which did show an association (p=<.05). Conclusion ASC was better among those in the MSG, while family background promoted a better adaptation as well.

Objetivo Comparar o nível de adaptação do autoconceito (NAA) nas pessoas que vivem com Diabetes mellitus tipo 2 (DT2), em dois cenários de uma unidade de primeiro nível. Metodologia Pesquisa descritiva, correlacional, comparativa e transversal com amostragem por conveniência; conformou-se por adultos com DT2 que assistem a controle mensal e ao grupo de ajuda mutua (GAM) em uma unidade de primeiro nível. Aplicou-se cédula de dados generais e instrumento Viveros03 (a=.85); realizou-se valorização antropométrica e glicemia capilar. A análise de dados foi com SPSS v. 20. A comprobação de hipótese foi mediante Shapiro-Wilk, T-student e Ji cuadrada. Resultados Trabalhou-se com 50 indivíduos, 25 do GAM (Grupo A) e 25 de controle ambulatório (Grupo B). O NAA do grupo A foi 60% integrado e do B foi de 68% compensatório, com diferença significativa entre ambos os grupos (p=0.02). Os estímulos contextuais como controle glicêmico, anos de diagnóstico e tratamento não demonstraram dependência (p > .05), contrário aos antecedentes familiares com diabetes e pertencer ao GAM onde houve uma relação (p=< 05). Conclusão O NAA foi melhor no GAM, a avaliação positiva do autoconceito teve um maior impacto, assim mesmo no GAM, os antecedentes familiares são estímulos contextuais que permitem a adaptação de maneira positiva.

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.

Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology. In this study, we found that endogenous levels of the dysbindin protein in the mouse brain are developmentally regulated, with higher levels observed during embryonic and early postnatal ages than in young adulthood. We obtained biochemical evidence indicating that the bulk of dysbindin from brain exists as a stable component of biogenesis of lysosome-related organelles complex-1 (BLOC-1), a multi-subunit protein complex involved in intracellular membrane trafficking and organelle biogenesis. Selective biochemical interaction between brain BLOC-1 and a few members of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) superfamily of proteins that control membrane fusion, including SNAP-25 and syntaxin 13, was demonstrated. Furthermore, primary hippocampal neurons deficient in BLOC-1 displayed neurite outgrowth defects. Taken together, these observations suggest a novel role for the dysbindin-containing complex, BLOC-1, in neurodevelopment, and provide a framework for considering potential effects of allelic variants in DTNBP1--or in other genes encoding BLOC-1 subunits--in the context of the developmental model of schizophrenia pathogenesis.

A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1).

The study of protein-protein interactions is a powerful approach to uncovering the molecular function of gene products associated with human disease. Protein-protein interaction data are accumulating at an unprecedented pace owing to interactomics projects, although it has been recognized that a significant fraction of these data likely represents false positives. During our studies of biogenesis of lysosome-related organelles complex-1 (BLOC-1), a protein complex involved in protein trafficking and containing the products of genes mutated in Hermansky-Pudlak syndrome, we faced the problem of having too many candidate binding partners to pursue experimentally. In this work, we have explored ways of efficiently gathering high-quality information about candidate binding partners and presenting the information in a visually friendly manner. We applied the approach to rank 70 candidate binding partners of human BLOC-1 and 102 candidates of its counterpart from Drosophila melanogaster. The top candidate for human BLOC-1 was the small GTPase encoded by the RAB11A gene, which is a paralogue of the Rab38 and Rab32 proteins in mammals and the lightoid gene product in flies. Interestingly, genetic analyses in D. melanogaster uncovered a synthetic sick/lethal interaction between Rab11 and lightoid. The data-mining approach described herein can be customized to study candidate binding partners for other proteins or possibly candidates derived from other types of 'omics' data.