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Curr Biol ; 30(24): 4910-4920.e5, 2020 12 21.
Artigo em Inglês | MEDLINE | ID: mdl-33065010

RESUMO

Channelrhodopsins (ChRs) are light-gated ion channels widely used as optogenetic tools for manipulating neuronal activity. The currently characterized ChR families include green algal and cryptophyte cation-conducting ChRs (CCRs) and cryptophyte, haptophyte, and stramenopile anion-conducting ChRs (ACRs). Here, we report the discovery of a new family of phylogenetically distinct ChRs encoded by marine giant viruses and acquired from their unicellular green algal hosts. These previously unknown viral and green algal ChRs act as ACRs when expressed in cultured neuroblastoma-derived cells and are likely involved in behavioral responses to light.


Assuntos
Channelrhodopsins/genética , Clorófitas/genética , Transferência Genética Horizontal , Genes Virais , Vírus Gigantes/genética , Animais , Ânions/metabolismo , Linhagem Celular , Channelrhodopsins/metabolismo , Clorófitas/metabolismo , Clorófitas/efeitos da radiação , Clorófitas/virologia , Vírus Gigantes/metabolismo , Células Híbridas , Luz , Metagenômica , Camundongos , Optogenética , Filogenia , Ratos
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