1.
Chem Commun (Camb)
; 49(6): 558-60, 2013 Jan 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23128288
RESUMO
The first synthesis of marinopyrrole B, which is highly active against methicillin-resistant Staphylococcus aureus, is described. The route involved constructing a pyrrole ring on the nitrogen of a 3-bromo-4,5-dichloropyrrole by N-alkylation with a special Michael acceptor having an allylic leaving group; the second pyrrole ring was then formed by a Paal-Knorr reaction.
Assuntos
Antibacterianos/síntese química , Pirróis/síntese química , Alquilação , Antibacterianos/química , Antibacterianos/farmacologia , Cristalografia por Raios X , Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos , Conformação Molecular , Pirróis/química , Pirróis/farmacologia , Estereoisomerismo
2.
J Org Chem
; 73(15): 6018-21, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18593186
RESUMO
Selenium-stabilized carbanions are available by a route that does not involve acid-catalyzed formation of selenoacetals. Aldehydes are converted first into alpha-hydroxystannanes and then into alpha-(phenylseleno)stannanes. Treatment with BuLi affords selenium-stabilized carbanions by preferential Sn/Li exchange.