Assuntos
Encefalite Antirreceptor de N-Metil-D-Aspartato , COVID-19 , Encefalite Antirreceptor de N-Metil-D-Aspartato/complicações , Encefalite Antirreceptor de N-Metil-D-Aspartato/diagnóstico por imagem , COVID-19/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética/métodos , Tomografia por Emissão de Pósitrons/métodos , SARS-CoV-2Assuntos
Hiperplasia do Linfonodo Gigante , Linfoma Difuso de Grandes Células B , Hiperplasia do Linfonodo Gigante/diagnóstico por imagem , Células Dendríticas Foliculares/patologia , Fluordesoxiglucose F18 , Seguimentos , Humanos , Linfoma Difuso de Grandes Células B/diagnóstico por imagem , Linfoma Difuso de Grandes Células B/patologia , Tomografia por Emissão de Pósitrons combinada à Tomografia ComputadorizadaRESUMO
El estudio gated-SPECT de perfusión miocárdica es una técnica utilizada e indicada para la valoración de los pacientes con un diagnóstico no claro de cardiopatía isquémica. El estudio gated-SPECT de reposo precoz en fase aguda tiene una alta sensibilidad y alto valor predictivo negativo para descartar enfermedad coronaria. Presentamos el caso de una paciente ingresada para el estudio de dolor torácico, a la que se le realizó un estudio de perfusión miocárdica de esfuerzo-reposo, cuyo resultado podría haber sido equívoco debido al estado clínico de la paciente durante la inyección del radiofármaco (AU)
Gated-SPECT myocardial perfusion imaging is a widely used technique indicated for assessment of patients with no clear diagnosis of ischemic heart disease. Early rest gated-SPECT myocardial perfusion study in patients with acute chest pain has high sensitivity and high negative predictive value for ruling out coronary disease. We report a case of a patient admitted for the study of her chest pain. She underwent a myocardial perfusion stress-rest whose interpretation could have been equivocal due to the clinical status of the patient during the injection of the radiotracer (AU)
Assuntos
Humanos , Feminino , Idoso , Tomografia Computadorizada por Emissão de Fóton Único de Sincronização Cardíaca/métodos , Tecnécio Tc 99m Sestamibi , Isquemia Miocárdica , Eletrocardiografia , Dor no PeitoRESUMO
Gated-SPECT myocardial perfusion imaging is a widely used technique indicated for assessment of patients with no clear diagnosis of ischemic heart disease. Early rest gated-SPECT myocardial perfusion study in patients with acute chest pain has high sensitivity and high negative predictive value for ruling out coronary disease. We report a case of a patient admitted for the study of her chest pain. She underwent a myocardial perfusion stress-rest whose interpretation could have been equivocal due to the clinical status of the patient during the injection of the radiotracer.
Assuntos
Tomografia Computadorizada por Emissão de Fóton Único de Sincronização Cardíaca/métodos , Dor no Peito/diagnóstico por imagem , Isquemia Miocárdica/diagnóstico por imagem , Imagem de Perfusão do Miocárdio/métodos , Idoso , Cateterismo Cardíaco , Diabetes Mellitus Tipo 2/complicações , Eletrocardiografia , Teste de Esforço , Reações Falso-Negativas , Feminino , Humanos , Hipertrigliceridemia/complicações , Compostos Radiofarmacêuticos , Tecnécio Tc 99m SestamibiRESUMO
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No disponible
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Diálise Peritoneal/efeitos adversos , Derrame Pleural/etiologia , Derrame PleuralAssuntos
Anormalidades Múltiplas/diagnóstico por imagem , Albuminas/farmacocinética , Aorta/diagnóstico por imagem , Fístula Artério-Arterial/diagnóstico por imagem , Pulmão/irrigação sanguínea , Angiografia por Ressonância Magnética , Compostos Radiofarmacêuticos/farmacocinética , Tetralogia de Fallot/cirurgia , Relação Ventilação-Perfusão , Adolescente , Aorta/anormalidades , Fístula Artério-Arterial/congênito , Circulação Colateral , Humanos , Masculino , CintilografiaRESUMO
OBJECTIVE: To study the influence of the 18F-FDG radioactive concentration and the usual greatest storage time of the radiopharmaceutical at the Radiopharmacy Unit (RU) over its radiochemical purity. MATERIAL AND METHODS: Thirty 18F-FDG preparations coming from different batches were studied. The radiochemical purity was determined at the RU by means of TLC to saline-diluted (1:10) and undiluted samples of each preparation, in the early 30 minutes since its arrival and 5 hours later. The radiochemical purity of the original 18F-FDG was determined at the PET radiopharmaceutical producer Laboratory (PETL) by means of HPLC in the early hour since the 18F-FDG dispensing. RESULTS: The increase of 18F-Fluoride found in the (5 h-30 min) period was significantly greater in the samples without diluting than in the diluted ones (p < 0.0001). We found a significant correlation between the percent of this increase of 18F-Fluoride (y) and the radioactive concentration of the 18F-FDG (x): y = 0.00061x + 0.1759 (R2 = 0.198; p < 0.0005). The percent of 18F-Fluoride determined at the RU was significantly higher than the percent of 18F-Fluoride determined at the PETL (p < 0.0001). A significant correlation between the differences of the percent of 18F-Fluoride determined by TLC and HPLC (y) and the radioactive concentration (x) was found: y = 0.0139x + 0.3146 (R2 = 0.196; p = 0.016). A significant correlation among the differences of percent 18F-Fluoride determined by TLC and HPLC ([%F] RU - [%F] PETL), the radioactive concentration (RC) and the time since the radiopharmaceutical dispensing (t) was found: [%F] RU - [%F] PETL = 0.01159*RC (mCi/mL) + 0.250*t (h) - 0.01903 (R2 = 0.226; p < 0.014). CONCLUSIONS: The stability of the 18F-FDG preparations with time increases when diminishing its concentration. We recommended the dilution of these preparations with physiological saline solution.
Assuntos
Fluordesoxiglucose F18/química , Acetilação , Cromatografia Líquida de Alta Pressão , Estabilidade de Medicamentos , Armazenamento de Medicamentos , Radioisótopos de Flúor/análise , Radioatividade , Fatores de TempoRESUMO
Objetivo. Determinar la influencia de la concentración radiactiva de la 2-[ 18F]-fluoro-2-desoxi-D-glucosa ( 18F-FDG) y el tiempo de almacenamiento máximo habitual del radiofármaco en la Unidad de Radiofarmacia (UR) sobre su pureza radioquímica. Material y métodos. Se estudiaron 30 preparaciones de 18F-FDG procedentes de lotes diferentes. Se determinó la pureza radioquímica en la UR dentro de los 30 minutos siguientes a su recepción y a las 5 horas mediante cromatografía en capa fina (TLC) a las muestras diluidas con suero salino fisiológico (1:10) y sin diluir. La pureza radioquímica también se determinó en el Laboratorio de radiofármacos PET (LPET) dentro de la primera hora posterior a su dispensación por cromatografía líquida a alta presión (HPLC). Resultados. El aumento de porcentaje de 18F-Fluoruro a las 5 horas fue significativamente mayor en las muestras sin diluir que en las diluidas (p < 0,0001), encontrándose una correlación significativa entre el aumento de porcentaje de 18F-Fluoruro con el tiempo (y) respecto a la concentración radiactiva (x): y = 0,0061x + 0,1759 (R 2 = 0,1977; p < 0,0005). El porcentaje de 18F-Fluoruro determinado en la UR fue significativamente mayor que el determinado en el LPET (p < 0,0001), obteniéndose una correlación significativa entre el aumento de porcentaje de 18F-Fluoruro (y) y la concentración radiactiva (x): y = 0,0139x + 0,3146 (R 2 = 0,196; p = 0,016). Se obtuvo una correlación significativa entre este aumento ([ %F] UR [ %F] LPET), la concentración radiactiva (CR) y el tiempo desde la dispensación (t): [ %F] UR [ %F] LPET = 0,01159*CR (mCi/ml) + 0,250*t (h) 0,01903 (R 2 = 0,226; p = 0,014). Conclusiones. La estabilidad de las preparaciones de 18F-FDG aumenta al disminuir su concentración. Aconsejamos la dilución de estas preparaciones con solución salina fisiológica
Objective. To study the influence of the 18F-FDG radioactive concentration and the usual greatest storage time of the radiopharmaceutical at the Radiopharmacy Unit (RU) over its radiochemical purity. Material and methods. Thirty 18F-FDG preparations coming from different batches were studied. The radiochemical purity was determined at the RU by means of TLC to saline-diluted (1:10) and undiluted samples of each preparation, in the early 30 minutes since its arrival and 5 hours later. The radiochemical purity of the original 18F-FDG was determined at the PET radiopharmaceutical producer Laboratory (PETL) by means of HPLC in the early hour since the 18F-FDG dispensing. Results. The increase of 18F-Fluoride found in the (5 h-30 min) period was significantly greater in the samples without diluting than in the diluted ones (p < 0,0001). We found a significant correlation between the percent of this increase of 18F-Fluoride (y) and the radioactive concentration of the 18F-FDG (x): y = 0,00061x + 0,1759 (R 2 = 0,198; p < 0,0005). The percent of 18F-Fluoride determined at the RU was significantly higher than the percent of 18F-Fluoride determined at the PETL (p < 0,0001). A significant correlation between the differences of the percent of 18F-Fluoride determined by TLC and HPLC (y) and the radioactive concentration (x) was found: y = 0,0139x + 0,3146 (R 2 = 0,196; p = 0,016). A significant correlation among the differences of percent 18F-Fluoride determined by TLC and HPLC ([ %F] RU [ %F] PETL), the radioactive concentration (RC) and the time since the radiopharmaceutical dispensing (t) was found: [ %F] RU [ %F] PETL = 0,01159*RC (mCi/mL) + 0,250*t (h) 0,01903 (R 2 = 0,226; p < 0,014). Conclusions. The stability of the 18F-FDG preparations with time increases when diminishing its concentration. We recommended the dilution of these preparations with physiological saline solution
