RESUMO
Schwann cells were identified in the tumor surrounding area prior to initiate the invasion process underlying connective tissue. These cells promote cancer invasion through direct contact, while paracrine signaling and matrix remodeling are not sufficient to proceed. Considering the intertwined structure of signaling, regulatory, and metabolic processes within a cell, we employed a genome-scale biomolecular network. Accordingly, a meta-analysis of Schwann cells associated transcriptomic datasets was performed, and the core information on differentially expressed genes (DEGs) was obtained by statistical analyses. Gene set over-representation analyses was performed on core DEGs to identify significantly functional and pathway enrichment analysis between Schwann cells and, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). DEGs were further integrated with genome-scale human biomolecular networks. miRNAs were proposed by the reconstruction of a transcriptional and post-transcriptional regulatory network. Moreover, microarray-based transcriptome profiling was performed, and the prognostic power of selected dedifferentiated Schwann cell biomolecules was predicted. We observed that pathways associated with Schwann cells dedifferentiation was overexpressed in lung cancer samples. However, genes associated with Schwann cells migration inhibition system were downregulated. Besides, miRNA targeting those pathways were also deregulated. In this study, we report valuable data for further experimental and clinical analysis, because the proposed biomolecules have significant potential as systems biomarkers for screening or for therapeutic purposes in perineural invasion of lung cancer.
RESUMO
Este trabalho objetiva apresentar o ensaio fotográfico das paredes do antigo presídio Desembargador Luiz de Oliveira Souza, em Arapiraca, Alagoas, Brasil. Trata-se de um produto do projeto de extensão intitulado "Itinerários, mostras de vidas", cujo objetivo é debater a realidade social sob a ótica do diálogo entre diferentes formas de expressão. Após desativação, o prédio foi doado à Universidade Federal de Alagoas (Ufal), sendo incorporado ao campus Arapiraca. Assim, surgiu a necessidade de manter um registro post factum do que um dia foi lugar de cumprimentos de penas. Trata-se de um ensaio capaz de revelar o cotidiano dos indivíduos que lá estiveram. Sob as lentes da câmera, as imagens contam-nos uma história.(AU)
This article presents a photographic essay of the walls of the former prison Desembargador Luiz de Oliveira Souza in Arapiraca, Alagoas, Brazil. It is one of the products of the extension project " Itinerários, mostras de vidas " (Itineraries, an exhibition of lives), whose aim is to debate social reality through the lens of dialogue between different forms of expression. After the prison was closed, the building was donated to the Federal University of Alagoas and incorporated into the Arapiraca campus. The need then arose to make a post factum record of what was once a place where sentences were served. The article comprises an essay capable of revealing the daily life of the individuals who were there. The images depict a story told through the lens of a camera.(AU)
El objetivo de este trabajo es presentar el ensayo fotográfico de las paredes del antiguo presidio Desembargador Luiz de Oliveira Souza, Arapiraca, Alagoas, Brasil. Se trata de un producto del proyecto de extensión titulado " Itinerários, mostras de vidas ", cuyo objetivo es debatir la realidad social bajo la óptica del diálogo entre diferentes formas de expresión. Después de la desactivación, el edificio fue donado a la Universidad Federal de Alagoas, habiéndose incorporado al campus Arapiraca. De esa forma, surgió la necesidad de mantener un registro post factum de lo que un día fue un local de cumplimiento de condenas. Se trata de un ensayo capaz de revelar el cotidiano de los individuos que estuvieron allí. A través de las lentes de la cámara las imágenes nos contaron una historia.(AU)
