Genetic Polymorphisms Associated with Early Implant Failure: A Systematic Review.

PURPOSE: Early implant failures have been observed in dental implant treatments even when the procedures are performed under appropriate conditions and in patients without local or systemic contraindications, suggesting that an intrinsic component of the patient could modify the osseointegration process. The objective of this systematic review was to analyze the association between early implant failure and genetic polymorphisms. MATERIALS AND METHODS: A systematic search was performed in the PubMed, ScienceDirect, and Scopus databases using the PRISMA statement as the main guidelines and "Dental implant" AND "Polymorphism" as search terms. The search cutoff date was August 2019. In addition, the risk of bias, methodologic quality, and heterogeneity of the included studies were analyzed. RESULTS: The search strategy yielded 225 articles, and the titles and abstracts were reviewed to evaluate if they were relevant to the subject. Twenty-four articles were selected for a complete reading, of which 10 articles met the inclusion criteria. Finally, five studies citing the association of the following polymorphisms with early implant failure were chosen: G-1607GG of the MMP 1 gene, C-799T of the MMP 8 gene, and -77 A>G of the gene MMP 13. CONCLUSION: The polymorphisms analyzed are from the promoter region, generating altered cellular transcriptional activity for MMP 1, MMP 8, and MMP 13, the effects of which are observed in inflammation and extracellular matrix degradation. Establishing a relationship between genetic polymorphisms and phenomena such as early implant loss is necessary for the development of precision medicine in the field of dentistry.

Multi-diffractive grating for surface plasmon biosensors with direct back-side excitation.

A multi-diffractive nanostructure is reported for the resonant excitation of surface plasmons that are cross-coupled through a thin metallic film. It consists of two superimposed periodic corrugations that allow diffraction excitation of surface plasmons on the inner side of a thin metal film and their subsequent phase matching with counterpropagating surface plasmons travelling to the opposite direction on its other side. This interaction leads to establishing of a set of cross-coupled Bragg-scattered surface plasmon modes that exhibit an electromagnetic field localized on both metal film interfaces. The reported structure is attractive for surface plasmon resonance biosensor applications, where direct optical probing can be done through the substrate without the need of optical matching to a high refractive index prism. In addition, it can be prepared by mass production - compatible means with UV-nanoimprint lithography and its biosensing performance characteristics are demonstrated by refractometric and biomolecular affinity binding studies.

Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis.

The sensitive analysis of small lipid extracellular vesicles (EVs) by using a grating-coupled surface plasmon resonance (GC-SPR) biosensor has been reported. In order to enable the analysis of trace amounts of EVs present in complex liquid samples, the target analyte is pre-concentrated on the sensor surface by using magnetic nanoparticles and its affinity binding is probed by wavelength interrogation of SPR. The GC-SPR has been demonstrated to allow for the implementation of efficient pulling of EVs to the sensor surface by using magnetic nanoparticles and an external magnetic field gradient applied through the sensor chip. This approach overcomes slow diffusion-limited mass transfer and greatly enhances the measured sensor response. The specific detection of different EV populations secreted from mesenchymal stem cells is achieved with a SPR sensor chip modified with antibodies against the surface marker CD81 and magnetic nanoparticles binding the vesicles via annexin V and cholera toxin B chain.

El tarjetero ginecobstétrico en la comunidad. Su aplicación en una porción de un sector de la comunidad de Alamar (1975-1976) / The gynecologic-obstetric card file in the community. Its use in an area of the Alamar community (1975-1976)

Se propone el uso de un tarjetero ginecobstétrico para el mejor control y evaluación de las pacientes atendidas en la comunidad. En cada tarjeta se consignan los datos más importantes desde el punto de vista obstétrico-ginecológico, tales como, edad, paridad, primeras relaciones sexuales, menarquia, trastornos menstruales, dolor, leucorrea, anticonceptivos, citología orgánica, etc. Se plantea que con dicho método se controla el total de mujeres de un área en cuestión; las gestantes y puérperas mediante el tarjetón de obstetricia y las pacientes con afecciones ginecológicas o supuestamente sanas con las tarjetas propuestas. Por último se hace una aplicación de dicho método de forma retrospectiva en una porción del sector A de la comunidad de Alamar; se expresan los resultados (AU)

Ginecobstetricia en la comunidad. Informe preliminar. Análisis del primer semestre de 1975 del policlínico docente "Alamar" / Gynecology-obstetrics in the community. Preliminary report. Analysis of 1975 first semester at the "Alamar" Teaching Policlinic

Se analiza una exposición del programa de atención médica, docencia e investigación en la comunidad, que se está aplicando a partir de launidad básica de salud, el policlínico, en el área de Alamar, al este de La Habana. Se exponen los resultados después del primer semestre de 1975, y se analizanlos datos estadísticos obtenidos que aportan nuevos elementos al conocimiento del universo de trabajo de la comunidad, en general, y de la ginecobstetricia en particular (AU)