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1.
J Theor Biol ; 469: 96-106, 2019 05 21.
Artigo em Inglês | MEDLINE | ID: mdl-30817924

RESUMO

Caprine Arthritis Encephalitis is an endemic disease in goat breedings, caused by viral strains belonging to the Small Ruminant Lentivirus group and characterized by a progressive chronic course. Its clinical signs are not immediately recognizable and can only be detected via costly serological tests. No vaccine is available. Two main strategies for fighting it are in common use. The "test-and-slaughter" approach, that selects infected goats and directly slaughters them, is expensive, time consuming and often leads to endemic low level persistence of the infection. Alternatively, newborns are removed from their mothers to be raised by healthy goats. After weaning they would rejoin their breeds, but then they could still be subject to horizontal contagion. In this study a mathematical model that considers the cocirculation of two different SRLV viral genotypes (B and E) is devised and analyzed, based on the key assumption of perfect cross-protection between the two genotypes' infections. Two strategic measures arise from its analysis, that are strongly recommended and whose implementation is encouraged: in the presence of both genotypes, the farmer should not isolate the newborns from their mothers but rather raise them with all the other animals. In the case of genotype-B-only affected farm, serological testing and mother-offspring separation should still be considered the best strategy for CAEV control. These strategies completely reverse the current removal policy and, in due conditions, would lead to disease eradication. These represent very reasonable and cheap measures for the eventual control of the epidemics.


Assuntos
Cruzamento , Cabras/virologia , Lentivirus/fisiologia , Animais , Modelos Biológicos
2.
Theor Popul Biol ; 116: 27-32, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-28690096

RESUMO

Spirochetes belonging to the Borrelia burgdoferi sensu lato (sl) group cause Lyme Borreliosis (LB), which is the most commonly reported vector-borne zoonosis in Europe. B. burgdorferi sl is maintained in nature in a complex cycle involving Ixodes ricinus ticks and several species of vertebrate hosts. The transmission dynamics of B. burgdorferi sl is complicated by the varying competence of animals for different genospecies of spirochetes that, in turn, vary in their capability of causing disease. In this study, a set of difference equations simplifying the complex interaction between vectors and their hosts (competent and not for Borrelia) is built to gain insights into conditions underlying the dominance of B. lusitaniae (transmitted by lizards to susceptible ticks) and the maintenance of B. afzelii (transmitted by wild rodents) observed in a study area in Tuscany, Italy. Findings, in agreement with field observations, highlight the existence of a threshold for the fraction of larvae feeding on rodents below which the persistence of B. afzelii is not possible. Furthermore, thresholds change as nonlinear functions of the expected number of nymph bites on mice, and the transmission and recovery probabilities. In conclusion, our model provided an insight into mechanisms underlying the relative frequency of different Borrelia genospecies, as observed in field studies.


Assuntos
Grupo Borrelia Burgdorferi , Borrelia , Comportamento Alimentar , Larva/microbiologia , Doença de Lyme/transmissão , Animais , Europa (Continente) , Lagartos , Camundongos , Modelos Biológicos , Dinâmica Populacional
3.
Eur J Sport Sci ; 15(5): 414-23, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25257354

RESUMO

In order to investigate the behaviour of athletes in choosing sports, we analyse data from part of the We-Sport database, a vertical social network that links athletes through sports. In particular, we explore connections between people sharing common sports and the role of age and gender by applying "network science" approaches and methods. The results show a disassortative tendency of athletes in choosing sports, a negative correlation between age and number of chosen sports and a positive correlation between age of connected athletes. Some interesting patterns of connection between age classes are depicted. In addition, we propose a method to classify sports, based on the analyses of the behaviour of people practising them. Thanks to this brand new classifications, we highlight the links of class of sports and their unexpected features. We emphasise some gender dependency affinity in choosing sport classes.


Assuntos
Atletas , Comportamento de Escolha , Modelos Teóricos , Rede Social , Esportes , Adulto , Feminino , Processos Grupais , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
4.
PLoS Comput Biol ; 10(11): e1003931, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25393293

RESUMO

The spread of tick-borne pathogens represents an important threat to human and animal health in many parts of Eurasia. Here, we analysed a 9-year time series of Ixodes ricinus ticks feeding on Apodemus flavicollis mice (main reservoir-competent host for tick-borne encephalitis, TBE) sampled in Trentino (Northern Italy). The tail of the distribution of the number of ticks per host was fitted by three theoretical distributions: Negative Binomial (NB), Poisson-LogNormal (PoiLN), and Power-Law (PL). The fit with theoretical distributions indicated that the tail of the tick infestation pattern on mice is better described by the PL distribution. Moreover, we found that the tail of the distribution significantly changes with seasonal variations in host abundance. In order to investigate the effect of different tails of tick distribution on the invasion of a non-systemically transmitted pathogen, we simulated the transmission of a TBE-like virus between susceptible and infective ticks using a stochastic model. Model simulations indicated different outcomes of disease spreading when considering different distribution laws of ticks among hosts. Specifically, we found that the epidemic threshold and the prevalence equilibria obtained in epidemiological simulations with PL distribution are a good approximation of those observed in simulations feed by the empirical distribution. Moreover, we also found that the epidemic threshold for disease invasion was lower when considering the seasonal variation of tick aggregation.


Assuntos
Reservatórios de Doenças/parasitologia , Camundongos/parasitologia , Infestações por Carrapato/veterinária , Animais , Biologia Computacional , Feminino , Masculino , Modelos Biológicos , Estações do Ano , Infestações por Carrapato/epidemiologia , Infestações por Carrapato/parasitologia , Carrapatos
5.
Artigo em Inglês | MEDLINE | ID: mdl-25122347

RESUMO

The structure of a network dramatically affects the spreading phenomena unfolding upon it. The contact distribution of the nodes has long been recognized as the key ingredient in influencing the outbreak events. However, limited knowledge is currently available on the role of the weight of the edges on the persistence of a pathogen. At the same time, recent works showed a strong influence of temporal network dynamics on disease spreading. In this work we provide an analytical understanding, corroborated by numerical simulations, about the conditions for infected stable state in weighted networks. In particular, we reveal the role of heterogeneity of edge weights and of the dynamic assignment of weights on the ties in the network in driving the spread of the epidemic. In this context we show that when weights are dynamically assigned to ties in the network, a heterogeneous distribution is able to hamper the diffusion of the disease, contrary to what happens when weights are fixed in time.


Assuntos
Doenças Transmissíveis/epidemiologia , Doenças Transmissíveis/transmissão , Epidemias , Modelos Teóricos , Gráficos por Computador , Humanos
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