Infección por parvovirus B1 9 con rash petequial en un adulto / No disponible

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[Acute pancreatitis and infection with the human immunodeficiency virus]. / Pancreatitis aguda e infección por el virus de la immunodeficiencia humana.

BACKGROUND: Retrospective study of the etiology and evolution of 40 episodes of acute pancreatitis in 28 patients infected with the human immunodeficiency virus (HIV). RESULTS: AIDS criteria were met by 89.3% of patients. The likely etiology was an opportunist infection in 32.5% of episodes, drug use in 22.5%, and biliary lithiasis in 5%. AP secondary to AIDS-associated cholangitis occurred in 35.7% of episodes. Sixty percent of episodes were severe in nature. The mortality rate reached 30%. CONCLUSIONS: AP in HIV infected patients: a) is more frequent in the advanced stages of disease; b) opportunistic infections and drugs are the most frequent causes in our environment; c) in a third of patients it is probably secondary to AIDS associated cholangitis; d) biliary lithiasis seems to be less common than in the general population, and e) it is associated with a high severity and mortality.

[Type I Gaucher's disease. Report of 2 affected families]. / Enfermedad de Gaucher tipo I. Descripción de dos familias afectadas.

Gaucher's disease (GD) is the most common lisosomic deposit disorders which is caused by an inherited deficit of the glucocerebrosidase enzyme. The most common for in the adult is type I and the clinical manifestations include liver and spleen enlargement, thrombocytopenia, and skeletal changes. Four patients with GD type I are here reported. They belonged to two different families and these underwent enzyme and genetic investigations. Eight healthy carriers were identified and the genetic counsel was given. The most relevant clinical manifestations included liver and spleen enlargement (3/4), thrombocytopenia (3/4), skeletal changes (2/4) and pulmonary involvement (1/4). Diagnosis was achieved by the demonstration of a decrease in the leukocyte enzymatic activity in the four patients. The mutation observed most frequently (66%) was N370S. The patient with pulmonary involvement has been under substitutive enzyme therapy for 9 months by means of alglucerase infusions (placental derivative of glucocerebrosidase), and an improvement in pulmonary function testing has been observed.

[Peritoneal pseudomyxoma secondary to mucinous cystadenoma of the ovary]. / Pseudomixoma peritoneal secundario a cistoadenoma mucinoso de ovario.

We present a new case of pseudomyxoma peritonei secondary to a mucinous cystadenoma of the ovary, whose presenting symptoms were abdominal distension and bilateral hernias. This is an uncommon entity and diagnosis tends to be casual. Each day, ultrasonography and computed tomography are more useful in suspicion. Aggressive surgical debulking followed by intraperitoneal chemotherapy seem to be the better treatment, even though controversies persist.