Assuntos
Glicemia/análise , Retinopatia Diabética/metabolismo , Ácidos Difosfoglicéricos/sangue , Hemoglobinas Glicadas/análise , Lipídeos/sangue , Consumo de Oxigênio , 2,3-Difosfoglicerato , Adulto , Colesterol/sangue , Retinopatia Diabética/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Triglicerídeos/sangueRESUMO
Recent research has demonstrated the major role of oxygen in the maintenance of normal cerebral function in the elderly and considerable importance has been attributed to the action of intra-erythrocytic 2-3 diphosphoglycerate (2-3 DPG) in favouring the availability of oxygen to the tissues. This property is reportedly helped or potentiated by the pharmacological action of some eumetabolic vasoregulator drugs. According to numerous clinical trials, (-)eburnamonine possesses this property. A two-part study was carried out in elderly volunteers: a double-blind randomized trial on 20 patients treated acutely (10 with an infusion of 100 mg (-)eburnamonine vs 10 controls) and a within-patients crossover trial on 10 patients treated chronically by the oral route. The results showed a significant increase in the 2-3 DPG values and a beneficial modification of P50 after (-)eburnamonine, probably dependent both on the dose and mode of administration. The effect of the drug was much more marked but more fleeting after acute administration and less intense but more lasting after chronic administration. The latter mode of treatment is of interest in view of the therapeutic effects on several symptoms of senile chronic cerebral insufficiency.
Assuntos
Consumo de Oxigênio/efeitos dos fármacos , Vasodilatadores/farmacologia , Alcaloides de Vinca/farmacologia , 2,3-Difosfoglicerato , Idoso , Ácidos Difosfoglicéricos/sangue , Método Duplo-Cego , Humanos , Oxiemoglobinas/metabolismo , Distribuição Aleatória , Fatores de TempoAssuntos
Arteriosclerose/tratamento farmacológico , Clofibrato/uso terapêutico , Dipiridamol/uso terapêutico , Adulto , Idoso , Doença das Coronárias/tratamento farmacológico , Combinação de Medicamentos , Avaliação de Medicamentos , Feminino , Humanos , Arteriosclerose Intracraniana/tratamento farmacológico , Masculino , Pessoa de Meia-IdadeRESUMO
The importance of loading tests, particularly venous loading with fructose, in the determination of changes in purine metabolism is stressed. Such changes may well be present even if basic uricaemia is within the limits of normal. Fructose loading was used to determine the hypouricaemising and uricosuric effects of a mediomineral water in aged subjects following daily administration. A hypouricaemising effect was noted and there was an improvement in loading curve patterns. This effect is considered to be primarily due to the uricosuric activity of the water itself. Sugar tolerance and the insulin response to loading, on the other hand, were not altered by the treatment.
