Synthesis of trifluoromethanesulfinamidines and -sulfanylamides.

Fluorinated moieties constitute important substituents used in many applications to modify the properties of molecules. The action of DAST onto Ruppert's reagent yields to a not isolable intermediate that can then react with various primary amines to give trifluoromethanesulfinamidines and trifluoromethanesulfanylamides. Such compounds were unknown until now and constitute interesting new families of fluorinated molecules.

Synthesis of alpha-trifluoromethylated nitrogen heterocycles.

The syntheses of various alpha-trifluoromethylated nitrogen heterocycles have been achieved from readily available alpha-(trifluoromethyl)homoallylamine through a ring-closing metathesis.