RESUMO
Our purpose was to obtain and characterize some collagen/hydroxyapatite (COLL/HA) hybrid composite materials with desired ceramic properties. The ceramic properties of these materials were achieved by combining two drying methods: controlled air drying at 30°C followed by freeze-drying. Through the function of the air drying times, the materials morphology varies from porous materials (when the materials are freeze-dried) up to dense materials (when the materials are air-dried), while the combined drying allows us to obtain an intermediary morphology. The composite materials intended to be used as bone grafts and in a drug delivery system were characterized by XRD, FTIR, SEM, and also by determining the ceramic properties by using the Arthur method. The ceramic properties of these COLL/HA composite materials vary in large range, for instance the density of the materials varies from 0.06 up to 1.5 g/cm(3) while the porosity varies from 96.5% down to 27.5%.
Assuntos
Cerâmica/química , Colágeno/química , Durapatita/química , Colágeno/síntese química , Materiais Dentários/química , Durapatita/síntese química , Liofilização , Manufaturas , Teste de Materiais , Microscopia Eletrônica de Varredura , Tamanho da Partícula , Porosidade , Espectroscopia de Luz Próxima ao Infravermelho , Difração de Raios XRESUMO
This work presents the synthesis of two hybrid materials: collagen (COLL)-polyvinyl alcohol (PVA) (1:2 wt) and collagen-polyvinyl alcohol/hydroxyapatite (HA) (1:2:3 wt). Starting from the above compositions, different kinds of composites were obtained based on the drying methods: controlled drying at 30°C and freeze drying. The materials were analysed by X-ray diffraction (XRD), Fourier transform infrared microscopy (FTIR) and scanning electron microscopy (SEM) as well as by measuring the density, porosity and absorption of xylene for each sample by Arthur method. Based on the SEM images, the freeze drying and the controlled drying could be clearly concluded to lead to porous and dense COLL-PVA/HA hybrid materials, respectively. Such materials have exhibited a stratified morphology, the distance between sheets increasing with the increase of the organic components content. Based on the literature data, the obtained COLL-PVA/HA composite materials are valuable bone grafts materials and drug delivery systems.
Assuntos
Colágeno/química , Durapatita/química , Álcool de Polivinil/química , Teste de Materiais , Microscopia Eletrônica de Varredura , Tamanho da Partícula , Porosidade , Espectroscopia de Infravermelho com Transformada de Fourier , Propriedades de Superfície , Difração de Raios X , Xilenos/químicaRESUMO
Our purpose was obtaining and characterizing a complex composite system with multifunctional role: bone graft material and hyperthermia generator necessary for bone cancer therapy. The designed system was a magnetite enriched collagen/hydroxyapatite composite material, obtained by a co-precipitation method. Due to the applied electromagnetic field the magnetite will induce hyperthermia and cause tumoral cell apoptosis. The complex bone graft system was characterised by XRD, FTIR and SEM, while the hyperthermia was quantify by measuring the temperature increase due to the applied alternative electromagnetical field.
