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2.
Urologe A ; 54(11): 1523-4, 1526-9, 2015 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-26573669

RESUMO

BACKGROUND: As of 31 December 2012, 92 departments of urology had been certified as a prostate cancer center by the German Cancer Society (DKG). In this paper, the treatment quality of these centers based on the annual 2014 DKG report shall be critically analyzed. BASIC DATA AND PATIENTS: In 2013, 19,558 primary cases of prostate cancer were registered. The mean number of primary cases per year was 159 (range 101-2089), whereby the minimum number of > 100 had been reached by all centers. The median number of radical prostatectomies decreased to 84 (range 35-2145); 6 of 88 centers did not fulfill the minimum number of 50 radical prostatectomies per year. Concerning radiotherapy or brachytherapy no minimal requirements exist. RESULTS: The number of operative revisions and wound infections including drainage of lymphoceles following radical prostatectomies and the relative number of nerve-sparing radical prostatectomies in low-risk patients with an IIEF > 22 are described. The requirement of < 10 % R1 resections was only fulfilled in 52 of 86 (60.5 %) centers; the median was 8.9 %. Data concerning treatment quality of external beam irradiation as well as data for potency and continence of all treatment modalities are completely lacking. CONCLUSION: The large number of registered prostate cancer cases offers the perfect opportunity to generate reliable benchmark data for all treatment modalities of prostate cancer. It is desirable that in the near future functional data such as continence and potency rates as well as prostate-specific antigen (PSA) recurrences of all treatment modalities will be reported.


Assuntos
Serviço Hospitalar de Oncologia/estatística & dados numéricos , Serviço Hospitalar de Oncologia/normas , Neoplasias da Próstata/epidemiologia , Neoplasias da Próstata/terapia , Garantia da Qualidade dos Cuidados de Saúde/estatística & dados numéricos , Sistema de Registros , Adulto , Idoso , Idoso de 80 Anos ou mais , Tratamento Farmacológico/normas , Tratamento Farmacológico/estatística & dados numéricos , Alemanha/epidemiologia , Fidelidade a Diretrizes/estatística & dados numéricos , Humanos , Masculino , Oncologia/normas , Pessoa de Meia-Idade , Guias de Prática Clínica como Assunto , Prostatectomia/normas , Prostatectomia/estatística & dados numéricos , Garantia da Qualidade dos Cuidados de Saúde/normas , Radioterapia/normas , Radioterapia/estatística & dados numéricos , Resultado do Tratamento
3.
Urologe A ; 54(11): 1530, 1532-6, 2015 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-26573670

RESUMO

BACKGROUND: Since the first prostate cancer center was certified by the German Cancer Society (DKG) in 2008, there are currently 94 centers at 95 sites. During certification, data on the implementation of the requirements are collected. These data can be used for benchmarking purposes. OBJECTIVES: This paper describes the development and monitoring of indicators and presents a selection of recent results. MATERIALS AND METHODS: The descriptive results on 18,288 primary cases from 91 sites with complete data are presented. RESULTS: The prostate cancer center certification system has reached a plateau both in regard to the absolute number of centers and the total proportion of all primary cases treated in Germany. The implementation of the requirements is at a high level overall, although some centers have difficulties fulfilling selected key figures, e.g., the study quota requirement. CONCLUSION: The evaluation of current indicators documented good structural and process quality, which correspond for the most part to the target values for the total cohort. In the future, assessing medium and long-term outcome quality will be of greater importance, particularly with regard to patient-reported outcomes.


Assuntos
Certificação/normas , Oncologia/normas , Serviço Hospitalar de Oncologia/normas , Neoplasias da Próstata/terapia , Garantia da Qualidade dos Cuidados de Saúde/normas , Indicadores de Qualidade em Assistência à Saúde/normas , Alemanha/epidemiologia , Humanos , Masculino , Guias de Prática Clínica como Assunto , Resultado do Tratamento
4.
Neoplasma ; 62(2): 278-87, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25591593

RESUMO

UNLABELLED: This study investigated differences in prevalence of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) and ETS transcription factor family member, v-ets erythroblastosis virus E26 oncogene homolog (ERG) fusion gene (TMPRSS2-ERG fusions) in clinically localized prostate cancer Japanese and German patients. A total of 105 specimens, including 69 Japanese and 36 German patients, were collected. The status of TMPRSS2-ERG fusion was determined by fluorescence in situ hybridization, and correlations of the TMPRSS2-ERG fusion with clinicopathological characteristics and immunohistochemistry were studied. Gene fusions were identified in 20% (14/69) of Japanese and 53% (19/36) of German patients (P < 0.001). The difference in the type of gene fusion between the two ethnic groups was statistically significant (P=0.024). Overexpression of ERG protein was significantly associated with gene fusion. Biochemical recurrence was significantly higher in patients with ERG overexpression than in those without, and not related to TMPRSS2-ERG fusion status. Interestingly, two types of gene fusions (deletion and increase of copy number) were significantly associated with increased p53 expression (P = 0.005). Association of specific gene fusions harboring higher genomic alterations with p53 expression levels suggests that p53 mutation might drive more aggressive arrangements of TMPRSS2-ERG fusion in prostate cancer. KEYWORDS: ERG, p53, prostate cancer, TMPRSS2-ERG fusion.

7.
Urologe A ; 53(8): 1136-45, 2014 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-25055808

RESUMO

Urology is affected by the demographic development in Germany more than any other medical discipline. Despite a relatively stable total population, by the year 2040 there will be an absolute and relevant increase in urological diseases caused only by the demographic development in the population. This is particularly true for the increase in oncological treatment just in the field of the discipline of urology. Even now the current numbers for tumor development in Germany (RKI 2014) in the urological oncology segment of all tumor diseases show an increasing trend with more than 23 %. This significant increase in performance is in contrast to the age development of the specialists in this discipline. In total but especially due to the significantly over-aged specialist medical profession in urology, this leads to a substantial bottleneck of specialists in the discipline of urology. This deficiency of personnel resources in urology is aggravated by the requirements of Generation Y for a well-adjusted work-life balance and the associated feminization of the medical profession. This requires intelligent strategies for.


Assuntos
Avaliação das Necessidades , Dinâmica Populacional , Neoplasias Urológicas/epidemiologia , Neoplasias Urológicas/terapia , Urologia/tendências , Alemanha/epidemiologia , Humanos , Incidência , Especialização/estatística & dados numéricos , Especialização/tendências , Recursos Humanos , Carga de Trabalho/estatística & dados numéricos
9.
Urologe A ; 51(4): 500, 502-6, 2012 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-22476801

RESUMO

In contrast to ureterosigmoidostomy no reliable clinical data exist for tumor risk in different forms of urinary diversion using isolated intestinal segments.In 44 German urological departments, operation frequencies, indications, patient age, and operation dates of the different forms of urinary diversion, operated between 1970 and 2007, could be registered. The secondary tumors up to 2009 were registered as well and related to the numbers of the different forms of urinary diversions resulting in tumor prevalences.In 17,758 urinary diversions 32 secondary tumors occurred. The tumor risk in ureterosigmoidostomy (22-fold) and cystoplasty (13-fold) is significantly higher than in other continent forms of urinary diversion such as neobladders or pouches (p<0.0001). The difference between ureterosigmoidostomy and cystoplasty is not significant, nor is the difference between ileocecal pouches (0.14%) and ileal neobladders (0.05%) (p=0.46). The tumor risk in ileocecal (1.26%) and colonic neobladders (1.43%) is significantly higher (p=0.0001) than in ileal neobladders (0.5%). Of the 16 tumors that occurred following ureterosigmoidostomy, 16 (94%) developed directly at the ureterocolonic borderline in contrast to only 50% following urinary diversions via isolated intestinal segments.From postoperative year 5 regular endoscopic controls of ureterosigmoidostomies, cystoplasties, and orthotopic (ileo-)colonic neobladders are necessary. In ileocecal pouches, regular endoscopy is necessary at least in the presence of symptoms or should be performed routinely at greater intervals. Following neobladders or conduits, only urethroscopies for urethral recurrence are necessary.


Assuntos
Anastomose Cirúrgica/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Derivação Urinária/estatística & dados numéricos , Neoplasias Urogenitais/epidemiologia , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Medição de Risco , Fatores de Risco , Adulto Jovem
11.
Aktuelle Urol ; 41 Suppl 1: S10-4, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20094944

RESUMO

INTRODUCTION/OBJECTIVE: Pelvic lymphadenectomy is the best method for staging localized prostate cancer. There is no consensus about how the pelvic lymphadenectomy should be performed for patients with cT2, Gleason score 7 or higher, PSA higher than 10 ng/mL. Scintigraphic studies of prostate lymph drainage show that many lymph nodes are not dissected according to the current recommendation of lymphadenectomy which could explain the high rate of cancer recurrence. The objectives of this work are an analysis of the local lymph node metastasis according to the preoperative data (digital examination, PSA and Gleason score) and a comparison between laparoscopic extended and limited pelvic lymphadenectomy, for staging, their technique and complications. METHODS: Two groups were created for analysis. The indications for laparoscopic pelvic lymph-adenectomy are the following: preoperative PSA 10 ng/mL or higher, Gleason score 7 or higher and/or digital examination cT2. Patients with suspected distant metastasis were excluded. The first group is composed of the patients who under-went a limited laparoscopic pelvic lymphadenectomy (LLPL) between January 1995 and December 2002. The medical data were analyzed retrospectively. The second group was created with patients who received extended laparoscopic pelvic lymphadenectomy (ELPL). These data were consecutively collected between November 2006 and October 2007. LLPL was the extraction of the external iliac and obturator lymph nodes. ELPL included, additionally, dissection of the internal iliac lymph nodes as well as tissue medial to the genitofemoral nerve. Histopathological findings were compared with serum PSA, histopathological stage and preoperative biopsy. Complications, operating time, and number of extracted lymph nodes were also compared. RESULTS: There were no significant differences in age, serum PSA or mean biopsy Gleason between two groups. The first group (LPLL) is composed of 381 patients and the second (ELPL), 163. The mean operating time was 72.5 minutes for LLPL and 84.3 for ELPL. The mean number of lymph nodes extracted was 13.8 (LLPL) and 31.1 (ELPL). Metastases were detected in 18.8% (LLPL) and 24.7% (ELPL). In 37.5% of cases, the metastasis occurred in lymph nodes outside from those dissected by LPLL. The rates of complications and conversion rate were not significantly different for the two groups. CONCLUSIONS: For patients with clinically localized prostate cancer, ELPL is associated with a higher rate of detection of lymph node metastasis outside of the field dissected in the LPLL. Pelvic lymphadenectomy, especially extraction of the lymph nodes of the internal iliac is important in patients with preoperative Gleason score 7 or greater and/or serum PSA greater than 10 ng/mL. Laparoscopic lymphadenectomy does not augment the rate of complications and is an excellent technique in prostate cancer staging.


Assuntos
Laparoscopia/métodos , Excisão de Linfonodo/métodos , Metástase Linfática/patologia , Neoplasias da Próstata/cirurgia , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/sangue , Humanos , Linfonodos/patologia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Complicações Pós-Operatórias/etiologia , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/patologia , Estudos Retrospectivos
12.
Urologe A ; 48(8): 874-6, 2009 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-19609500

RESUMO

A financial adjustment of the scale of medical fees (GoA) has not been undertaken for 27 years so that in 2007 the medical profession must work and run the practice with charge rates from 1982. The Medical Council considers an increase in the proceeds of the GoA catalogue of services with adjustment according to the development of costs and income to be indispensible.


Assuntos
Honorários Médicos/tendências , Previsões , Custos de Cuidados de Saúde/tendências , Urologia/economia , Urologia/tendências , Alemanha
14.
Urologe A ; 47(3): 348-56, 2008 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-18292983

RESUMO

Since the new Regulation on Continuing Education took effect, documentation of continuing education is obligatory. At the beginning of 2007, the German Society of Residents in Urology (GeSRU) together with the German Society of Urology (DGU) represented by Professor J. Fichtner initiated a project group with the goal of enhancing the transparency of urological continuing education, modernizing it, and implementing the new possibilities afforded by the new regulation on a nationwide level. Towards realizing this project, which was joined by the Federation of German Urologists (BDU) and the Working Group of Hospital Chiefs of Staff, a joint logbook was designed. In contrast to previously obtainable logbooks, the joint logbook offers, in addition to straightforward documentation of continuing education, a definitive, clear interview guide based on objective data analysis. It provides training in agreeing on sensible objectives, it contains a model curriculum in which continuing education can be systematically yet flexibly structured, and beyond the requirements needed for obtaining qualification as a specialist includes those entitling the physician to bill health insurance providers for urological services rendered as a private practitioner. The joint logbook is accepted as an all-in-one continuing education unit record by the medical associations, health insurance providers, and the European Board of Urology. It takes the form of a dual concept and is available in hard copy as a loose-leaf binder and in a constantly updated online version (http://www.germanresidents-urolog.de).


Assuntos
Documentação/normas , Educação Médica Continuada/legislação & jurisprudência , Educação de Pós-Graduação em Medicina/legislação & jurisprudência , Programas Nacionais de Saúde/legislação & jurisprudência , Garantia da Qualidade dos Cuidados de Saúde/legislação & jurisprudência , Sociedades Médicas , Urologia/educação , Acreditação/legislação & jurisprudência , Currículo , Documentação/métodos , Alemanha , Humanos , Internato e Residência
15.
Urologe A ; 47(3): 304-13, 2008 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-18210076

RESUMO

BACKGROUND: The German diagnosis-related group (G-DRG) system is based on the belief that there is only one specific coding for each case. The aim of this study was to compare coding results of identical cases coded by different coding specialists. MATERIAL AND METHODS: Charts of six anonymous cases -- except final letter and coding -- were sent to 20 German departments of urology. They were asked to let their coding specialists do a DRG coding of these cases. The response rate was 90%. RESULTS: Each case was coded in a different way by each coding specialist. The DRG refunding varied by 6-23%. The coding differences were caused by different interpretations of definitions in the DRG system and also by inaccurate chart analysis. CONCLUSION: The present DRG system allows a wide range of interpretation, leading to aggravation of the ongoing disputes between hospitals and insurance companies.


Assuntos
Grupos Diagnósticos Relacionados/classificação , Grupos Diagnósticos Relacionados/economia , Classificação Internacional de Doenças/classificação , Classificação Internacional de Doenças/economia , Programas Nacionais de Saúde/economia , Escalas de Valor Relativo , Doenças Urológicas/classificação , Doenças Urológicas/economia , Idoso de 80 Anos ou mais , Dissidências e Disputas , Feminino , Controle de Formulários e Registros/classificação , Controle de Formulários e Registros/economia , Alemanha , Guias como Assunto , Custos Hospitalares/classificação , Custos Hospitalares/estatística & dados numéricos , Humanos , Tempo de Internação/economia , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Mecanismo de Reembolso/economia , Reprodutibilidade dos Testes , Doenças Urológicas/terapia
17.
Urologe A ; 45(10): 1255-6, 1258-9, 2006 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-17006700

RESUMO

Relapses after curative therapy for localised prostate cancer using radiotherapy or radical prostatectomy occur in a significant percentage of cases, even in times of continually improving patient selection. The definition of a biochemical relapse after surgery is a PSA value of >or=0.4 ng/ml. After radiotherapy with maintenance of the organ and residual PSA production the definition is more complicated. The current algorithm is based on the ASTRO consensus of 1996 and defines a relapse as three consecutive increases in PSA above the post-therapeutic low. A biochemical relapse can indicate a local relapse, systemic metastasising of the disease or a combination of both. The differentiation of these two possibilities can be made, apart from imaging modalities, primarily on the basis of variation in PSA kinetics, whereby a short PSA doubling time and early PSA increase after primary therapy indicate a systemic problem.


Assuntos
Recidiva Local de Neoplasia/sangue , Recidiva Local de Neoplasia/prevenção & controle , Antígeno Prostático Específico/sangue , Prostatectomia , Neoplasias da Próstata/sangue , Neoplasias da Próstata/terapia , Radioterapia Adjuvante , Biomarcadores Tumorais/sangue , Humanos , Masculino , Neoplasias da Próstata/diagnóstico , Resultado do Tratamento
19.
Aktuelle Urol ; 34(7): 475-7, 2003 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-14655084

RESUMO

OBJECTIVE: Renal embolisation offers a minimal invasive means of renal ablation under primary palliative indication. We evaluated our experience with this technique in a series of 40 patients. PATIENTS AND METHODS: From 1996 to 2002 a total of 40 patients underwent total embolisation of the kidney. Our patients encompassed 15 females and 25-males (median age: 68 years, 46 - 89 years). In 15 patients indication for embolisation was to ablate a non-functioning kidney following obstruction due to advanced cancer, in 9 patients preoperatively with advanced renal cell carcinomas invading the vena cava, in 8 patients for control of hematuria and in 8 patients with non-operable advanced renal cancers. The embolisation was carried out in DAS-technique with a 7 Fr. selective catheter and central placement of macrocoils, from 2000 on we additionally performed a peripheral embolisation with polyvinylalcohol (PVA) particles. The intervention took place in epidural anesthesia. RESULTS: Perioperatively in all patients a complete occlusion of the renal artery as well as acessory arteries (n = 6) could be documented radiographically, perioperative complications were not observed. A post-embolisation syndrome occured in 32 patients. Reinterventions with repeat embolisation became necessary in 5 patients (persistent urine production-n = 4, persistent hematuria-n = 1). SUMMARY: The combined central and peripheral embolisation of the kidney in epidural anesthesia is a valuable means in selected patients under palliative indication for defunctionalisation of the kidney as well as control of hematuria.


Assuntos
Carcinoma de Células Renais/terapia , Embolização Terapêutica , Neoplasias Renais/terapia , Artéria Renal , Idoso , Idoso de 80 Anos ou mais , Anestesia Epidural , Carcinoma de Células Renais/cirurgia , Embolização Terapêutica/efeitos adversos , Embolização Terapêutica/métodos , Feminino , Hematúria/terapia , Humanos , Neoplasias Renais/cirurgia , Masculino , Pessoa de Meia-Idade , Nefrectomia , Cuidados Paliativos , Seleção de Pacientes , Cuidados Pré-Operatórios
20.
Aktuelle Urol ; 34(4): 223-5, 2003 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-14566668

RESUMO

PURPOSE: Radical perineal prostatectomy has recently attracted renewed interest and wider acceptance as an alternative route to the retropubic approach. While presumed lower morbidity is one reason for perineal prostatectomy we evaluated our patients for complications that are specific for the perineal approach. PATIENTS AND METHODS: We have retrospectively analyzed 412 patients who underwent perineal prostatectomy from 10/1996 to 12/2000. Patients for the perineal approach were selected on the base of preoperative PSA (10 ng/ml) and biopsy Gleason score (< 7) without the need for simultaneous lymphadenectomy. A cystogram was performed routinely on day 7 p. o. and the catheter removed when patent anastomosis was confirmed. Intra-, peri- and postoperative complications were recorded and evaluated. RESULTS: Intraoperative complications encompassed 22 cases of rectal injury (5.5 %) with standard primary 2-layer closure, however 4 patients subsequently developed a stool fistula and 3 required a colostomy. Hematoma in the prostatic fossa was diagnosed in 21 patients (5.2 %) and was removed surgically due to infection or increasing size in 4 patients. In 6.5 % of the patients acute urinary retention occurred after catheter removal (91 % after 7 days), while 4.2 % showed urinary extravasation via the perineal wound. Both incidents healed uneventfully with prolonged catheterization in all except 2 cases with concomitant hematoma in whom open fistula closure with a tunica vaginalis graft was performed. The rate of perioperative transfusion was 6.4 %, transient paresthesia and weakness of the leg were observed in 3 patients. CONCLUSIONS: Radical perineal prostatectomy seems to be a procedure with a low rate of complications and surgical reinterventions. However, the spectrum of observed complications is different to that of retropubic prostatectomy and requires specific management.


Assuntos
Períneo , Complicações Pós-Operatórias , Prostatectomia/métodos , Neoplasias da Próstata/cirurgia , Biópsia , Humanos , Complicações Intraoperatórias , Masculino , Próstata/patologia , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/sangue , Neoplasias da Próstata/patologia , Reoperação , Estudos Retrospectivos , Fatores de Tempo
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