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1.
Pediatr Infect Dis J ; 29(8): 728-30, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20661101

RESUMO

BACKGROUND: A shigellosis outbreak in the St Louis, Missouri metropolitan area. OBJECTIVE: To evaluate the utility of a second convalescent stool culture following an initial negative convalescent stool culture among persons excluded from work or childcare for shigellosis. METHODS: An observational study of 219 shigellosis cases. Laboratory-confirmed shigellosis patients who are required to submit 2 negative convalescent stool cultures before returning to childcare facilities or work and who submitted at least 1 culture were included in the study. Univariate and multivariable logistic regression analyses were performed to evaluate potential risk factors for a convalescent stool culture being positive. RESULTS: Of 308 persons, 219 (71%) submitted at least 1 convalescent stool culture, and 164 (53%) submitted 2 negative convalescent stool cultures. Among 172 cases with > or =2 follow-up cultures, the probability that the second test result would agree with the first test result was 7% for a "positive" initial stool culture, and 100% for a "negative" stool culture. When adjusted for age, sex, and child care attendance, treated case-patients who had Shigella organisms in the first convalescent culture were more likely to have had stool collected <48 hours after the treatment completion and were more likely to have been treated with trimethoprim-sulfamethoxazole. CONCLUSIONS: Compliance is poor with statutes requiring serial negative stool cultures among certain populations with shigellosis. Absence of Shigella species in the first convalescent stool culture of patients recovering from shigellosis appears to be an adequate measure of bacteriologic cure; however, the health impacts of requiring any convalescent cultures during shigellosis outbreaks remain unclear.


Assuntos
Surtos de Doenças , Disenteria Bacilar/epidemiologia , Disenteria Bacilar/microbiologia , Fezes/microbiologia , Shigella/isolamento & purificação , Adolescente , Adulto , Criança , Pré-Escolar , Disenteria Bacilar/tratamento farmacológico , Fidelidade a Diretrizes/estatística & dados numéricos , Humanos , Lactente , Masculino , Missouri/epidemiologia , Valor Preditivo dos Testes , Adulto Jovem
2.
Mo Med ; 106(6): 420-4, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20063513

RESUMO

This is a case-control study of viral meningitis outbreak in Perry County, Missouri. All case-patients had viral meningitis per routine CSF analysis or PCR testing. Enterovirus VP1-specific RT-PCR and sequencing was performed on CSF. Univariate and multivariable logistic regression analysis was done to evaluate risk factors. The meningitis attack rate was 1/1,000 population. The main risk factor for meningitis was association with childcare. In patients with signs of meningitis, but normal routine CSF analysis, molecular testing of the CSF is helpful for conclusive diagnosis.


Assuntos
Creches , Surtos de Doenças , Infecções por Echovirus/epidemiologia , Meningite Viral/epidemiologia , Adolescente , Distribuição por Idade , Criança , Pré-Escolar , Infecções por Echovirus/líquido cefalorraquidiano , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Meningite Viral/líquido cefalorraquidiano , Missouri , Razão de Chances , Reação em Cadeia da Polimerase , Fatores de Risco , População Rural , Distribuição por Sexo , Cultura de Vírus
3.
Pediatr Dermatol ; 25(6): 643-4, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19067877

RESUMO

We conducted an investigation of a rash outbreak in children who attended the "Mud Mania Festival." The mean incubation period of illness was 26 hours, and mean duration was 4.3 days. Time spent in mud was associated with the extent of rash in a dose-response fashion. The cultures from lesions of two unrelated cases yielded Enterobacter cloacae.


Assuntos
Surtos de Doenças , Exantema/epidemiologia , Exantema/etiologia , Recreação , Solo , Adolescente , Criança , Pré-Escolar , Enterobacter cloacae/isolamento & purificação , Exantema/microbiologia , Exantema/patologia , Humanos , Índice de Gravidade de Doença , Fatores de Tempo
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