Assuntos
Doenças do Cão/patologia , Corpos Estranhos/veterinária , Abscesso/etiologia , Abscesso/veterinária , Animais , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia , Cães , Corpos Estranhos/complicações , Corpos Estranhos/patologia , Corpos Estranhos/cirurgia , Masculino , Radiografia , Ferimentos Penetrantes/patologia , Ferimentos Penetrantes/cirurgia , Ferimentos Penetrantes/veterináriaRESUMO
The purpose of this study was to describe the clinical and gross pathological findings, treatment, and outcome in three dogs receiving deracoxib that developed proximal duodenal perforation and subsequent septic peritonitis. Clinical findings were acute vomiting and anorexia following initiation of deracoxib therapy. Deracoxib dosages ranged from 2 to 3 mg/kg per os q 24 hours. In each dog, exploratory laparotomy revealed duodenal perforations approximately 1 cm orad to the major duodenal papilla. Two out of three dogs survived following exploratory laparotomy. Two of three dogs in the present case series received the approved deracoxib dosage. Dogs receiving deracoxib, even at labeled dosages, should be monitored judiciously for signs of gastrointestinal disease.
Assuntos
Doenças do Cão/induzido quimicamente , Duodenopatias/veterinária , Perfuração Intestinal/veterinária , Peritonite/veterinária , Sulfonamidas/efeitos adversos , Animais , Inibidores de Ciclo-Oxigenase/efeitos adversos , Inibidores de Ciclo-Oxigenase/uso terapêutico , Doenças do Cão/diagnóstico , Doenças do Cão/cirurgia , Cães , Duodenopatias/induzido quimicamente , Duodenopatias/complicações , Duodenopatias/cirurgia , Evolução Fatal , Perfuração Intestinal/induzido quimicamente , Perfuração Intestinal/complicações , Perfuração Intestinal/cirurgia , Masculino , Peritonite/etiologia , Peritonite/cirurgia , Sulfonamidas/uso terapêutico , Resultado do TratamentoAssuntos
Doenças do Cão/diagnóstico , Neoplasias Penianas/veterinária , Animais , Antibacterianos/uso terapêutico , Cistite/tratamento farmacológico , Cistite/etiologia , Cistite/veterinária , Diagnóstico Diferencial , Doenças do Cão/cirurgia , Cães , Disuria/etiologia , Disuria/veterinária , Masculino , Neoplasias Penianas/diagnóstico , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/veterinária , Resultado do TratamentoRESUMO
OBJECTIVE: To assess gross and histologic tissue responses of skin incisions closed by use of absorbable subcuticular staples, cutaneous metal staples, and polyglactin 910 suture in pigs. ANIMALS: 8 purpose-bred disease-free pigs. PROCEDURE: Pigs were randomly allocated to 1 of 4 groups from which tissues were collected after death on postoperative days (PODs) 7, 14, 21, or 42. In each pig, 4 incisions were made; 1 was closed subcuticularly with 3-0 polyglactin 910 suture, 1 was closed with metal staples, and 2 were closed with absorbable subcuticular staples. Incision sites were grossly evaluated every 3 days after closure. At necropsy, incision sites and surrounding tissues were examined histologically; a histopathologic scoring system was used to quantitate healing and tissue response directed against the closure material. RESULTS: Postoperatively, the metal staples induced a severe inflammatory response, compared with minimal inflammation associated with the suture or absorbable subcuticular staples. Histologic evaluation of incisions on PODs 7, 14, and 21 revealed less severe inflammation associated with absorbable subcuticular staples than that associated with the other materials. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that absorbable subcuticular staples induced a less severe inflammatory response in the early stages of healing in pigs, compared with other commonly used methods of wound closure. Use of absorbable staples potentially combines the benefits of subcuticular closure with the speed and precision of staple placement.
