RESUMO
We studied the effect of SR33805, a calcium channel blocker, in vitro on the proliferation of vascular smooth muscle cells (SMC) stimulated by foetal calf serum, basic fibroblast growth factor and platelet derived growth factor, and in vivo with regard to SMC migration and proliferation which occurred following injury of the porcine carotid artery. The intimal lesion was induced by a silasten collar surgically positioned around the carotid artery and by a stenosis reducing blood flow by 50% for 30 days. Animals received SR33805 (5 mg/kg/day) 8 days before the induction of the lesion and up to 30 days after. In vitro, SR33805 inhibited in a dose-dependent manner growth factor-induced proliferation of SMC (0.20Assuntos
Bloqueadores dos Canais de Cálcio/farmacologia
, Artéria Carótida Primitiva/patologia
, Indóis/farmacologia
, Sulfonas/farmacologia
, Túnica Íntima/patologia
, Animais
, Arteriopatias Oclusivas/patologia
, Arteriopatias Oclusivas/prevenção & controle
, Lesões das Artérias Carótidas
, Artéria Carótida Primitiva/efeitos dos fármacos
, Contagem de Células
, Divisão Celular/efeitos dos fármacos
, Masculino
, Microscopia de Vídeo
, Músculo Liso Vascular/efeitos dos fármacos
, Músculo Liso Vascular/patologia
, Suínos
, Túnica Íntima/efeitos dos fármacos