RESUMO
A series of 3,6-bis(aminoalkoxy)acridines (2) was prepared and shown to have a protective antiviral effect against an interferon-sensitive virus (Columbia SK) and to partially restore an antibody response to a T-cell-dependent antigen in leukemic immunosuppressed mice. The presence of circulating interferon and the stimulation of natural killer cell activity in mice was observed for 21.
Assuntos
Acridinas/síntese química , Formação de Anticorpos/efeitos dos fármacos , Acridinas/farmacologia , Animais , Antivirais/síntese química , Antivirais/farmacologia , Terapia de Imunossupressão , Células Matadoras Naturais/efeitos dos fármacos , Células Matadoras Naturais/imunologia , CamundongosRESUMO
Bisamidines of 2,6-diaminoanthraquinone have demonstrated potent activity against cecal and hepatic Entamoeba histolytica infections in rats and hamsters, respectively. A number of these compounds compared favorably, in overall drug efficacy, with metronidazole and other standard agents.
Assuntos
Amebíase/tratamento farmacológico , Antraquinonas/uso terapêutico , Entamebíase/tratamento farmacológico , Amidinas/uso terapêutico , Animais , Cricetinae , Relação Dose-Resposta a Droga , Entamoeba histolytica , Feminino , Ratos , Relação Estrutura-AtividadeRESUMO
A series of bisamidines of 2,6-diaminoanthraquinone was synthesized and tested against cecal and hepatic forms of Entamoeba histolytica infections in rats and hamsters, respectively. A number of compounds were found to have good activity against infections in both species.