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1.
Orbit ; 37(5): 352-357, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29388848

RESUMO

Primary orbital melanoma (POM) is a very rare condition. We report further four cases and review all previously reported cases. We present a multicentre retrospective review of patients with POM. Clinical, radiological, surgical, histological, and follow-up data is presented. Four patients with POM were identified between 2000 and 2013. All presented with proptosis and diplopia without reduced vision. Two had known pre-existing blue cell naevi. All were stage T1N0M0. All underwent exenteration with adjuvant radiotherapy. All are disease free at follow-up durations of 24-151 months. The present three cases and review of all cases in the literature suggest a higher likelihood of disease-free survival from primary exenteration (7/8 disease-free survival, 1/8 death from metastatic disease) than wide local excision (7/16 disease-free survival, 9 recurrence or metastasis of whom 4 died). Adjuvant radiotherapy may additionally improve outcomes.


Assuntos
Melanoma/patologia , Neoplasias Orbitárias/patologia , Adulto , Idoso , Biomarcadores Tumorais/análise , Diplopia/diagnóstico , Exoftalmia/diagnóstico , Feminino , Seguimentos , Humanos , Masculino , Melanoma/radioterapia , Melanoma/cirurgia , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Procedimentos Cirúrgicos Oftalmológicos , Neoplasias Orbitárias/radioterapia , Neoplasias Orbitárias/cirurgia , Radioterapia Adjuvante , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
2.
Br J Ophthalmol ; 102(8): 1147-1153, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29146762

RESUMO

PURPOSE: To study the natural history, clinical and radiological characteristics of primary paediatric optic nerve sheath meningioma (PPONSM). METHODS: Retrospective study of eight paediatric patients who were treated between 1994 and 2016 at the University Hospital Zurich, Switzerland and the Royal Adelaide Hospital, Australia. Clinical records and imaging studies were reviewed. RESULTS: The mean age at presentation was 11 years (range: 6-17 years). There were six female patients and two male patients. 2/8 patients had associated neurofibromatosis type 2. Patients were followed up for 71-297 months (mean 156±70 months). 6/8 patients were observed through the course of their disease and 2/8 patients were treated with radiotherapy. 2/8 patients who were observed had minimal change in vision and did not experience tumour growth after long-term follow-up. CONCLUSIONS: This is the largest PPONSM case series with long-term data on patients treated conservatively. We highlight that a small subset of these tumours are indolent and can be managed using observation alone.


Assuntos
Imageamento por Ressonância Magnética , Meningioma/diagnóstico por imagem , Neurofibromatose 2/diagnóstico por imagem , Neoplasias do Nervo Óptico/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Adolescente , Criança , Feminino , Seguimentos , Humanos , Masculino , Meningioma/patologia , Meningioma/radioterapia , Neurofibromatose 2/patologia , Neurofibromatose 2/radioterapia , Neoplasias do Nervo Óptico/patologia , Neoplasias do Nervo Óptico/radioterapia , Estudos Retrospectivos , Acuidade Visual , Campos Visuais
3.
Orbit ; 36(5): 273-284, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28700281

RESUMO

This is a systematic review of eyebrow reconstruction options, using the PubMed database, as well as dermatology and plastic surgery texts. Eyebrow reconstruction options in various clinical scenarios (small, large, medial, lateral, and total defects) are presented. The goals of eyebrow reconstruction are to provide structural, functional, and aesthetic restoration. A good understanding of various eyebrow reconstruction techniques is essential for plastic, dermatologic, and oculoplastic surgeons.


Assuntos
Sobrancelhas , Procedimentos Cirúrgicos Oftalmológicos , Procedimentos de Cirurgia Plástica/métodos , Cabelo/transplante , Humanos , Transplante de Pele , Retalhos Cirúrgicos
5.
Orbit ; 35(3): 144-56, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27171562

RESUMO

Malignant hair follicle tumors are rare skin adnexal malignancies that have a predilection for the head and neck region. They can be categorized into a number of different subtypes. Histologically, they are distinct from their benign counterpart. To the best of our knowledge, there is no extensive review of these malignancies, especially in the periorbital region. We aim to provide a literature review and a guideline for management of these malignant tumors in the periorbital region. Database from Medline, PubMed, Embase, and Google Scholar were consulted. A total of 16 cases from the literature on hair follicle malignancies in the periorbital region were included in this review. The clinical presentations, diagnostic patterns, investigations used, and best management approach of these tumors are discussed. The American Joint Committee on Cancer (AJCC) 7(th) edition carcinoma of the eyelid staging system was used to describe their behaviors. We recommend wide excision surgery and a close follow-up for these tumors. Tumors presenting with a late stage require work-up for distant metastasis and consideration for exenteration procedures. The role of radiotherapy and chemotherapy in this context is still uncertain.


Assuntos
Neoplasias Palpebrais/terapia , Doenças do Cabelo/terapia , Folículo Piloso/patologia , Neoplasias Cutâneas/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Neoplasias Palpebrais/diagnóstico , Feminino , Doenças do Cabelo/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/diagnóstico
6.
Br J Ophthalmol ; 100(11): 1517-1520, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26837505

RESUMO

INTRODUCTION: Necrotising fasciitis (NF) is a severe infection of deep subcutaneous soft tissues with high morbidity and mortality. Periocular necrotising fasciitis (PONF) is a very rare condition with many unanswered questions about the presentation and management. We present a retrospective case series of patients with PONF from three centres in Australia and two in the UK to investigate the clinical and microbiological characteristics and outcomes and report on patients treated with antibiotics alone. RESULTS: Twenty-nine patients (20 men; 69%) with PONF were identified and followed up for between 2 months and 10 years (median 57, mean 52.6 months) between 1990 and 2013. Conditions associated with chronic immunocompromise were present in 16/29 (55%). Twenty-one (75%) recalled minor periocular trauma or an infected lesion, two having been assaulted by the same assailant. Systemic shock occurred in 6/29 (21%) patients and 1 died. Group A, ß-haemolytic Streptococcus was the most common bacterium identified (25/29, 86%). Intravenous antibiotics were used in all patients, and up to five tissue debridements were required to control the disease in 23/29 (74%); reconstructive surgery was required in 12/29 (41%) patients. One patient died from the disease and visual loss occurred in four eyes of four patients (14%). CONCLUSIONS: PONF has a better prognosis than disease elsewhere in the body, but is still associated with significant risk of visual loss and a small risk of death. Intravenous antibiotic treatment with cautious observation may be reasonable in selected patients with a low threshold for debridement.


Assuntos
Antibacterianos/uso terapêutico , Desbridamento/métodos , Fasciite Necrosante/terapia , Doenças Orbitárias/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Fasciite Necrosante/diagnóstico , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Orbitárias/diagnóstico , Prognóstico , Estudos Retrospectivos , Fatores de Tempo , Adulto Jovem
8.
Ophthalmic Plast Reconstr Surg ; 32(6): e126-e128, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-25198396

RESUMO

The authors describe a case of T-cell large granular lymphocytic leukemia nodular lesion of the eyelid. To their knowledge, this has not been reported previously to occur in the eyelids. They have also reviewed previous literature reports on similar skin lesions in areas elsewhere.


Assuntos
Pálpebras/diagnóstico por imagem , Leucemia Linfocítica Granular Grande/diagnóstico , Linfócitos T/patologia , Idoso , Biópsia , Feminino , Citometria de Fluxo , Humanos
9.
Future Oncol ; 11(22): 3003-10, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26437207

RESUMO

Basal cell carcinoma (BCC) is the most common eyelid malignancy; however, orbital invasion by periocular BCC is rare, and management remains challenging. Established risk factors for orbital invasion by BCC include male gender, advanced age, medial canthal location, previous recurrences, large tumor size, aggressive histologic subtype and perineural invasion. Management requires a multidisciplinary approach with orbital exenteration remaining the treatment of choice. Globe-sparing treatment may be appropriate in selected patients and radiotherapy and chemotherapy are often used as adjuvant therapies for advanced or inoperable cases, although the evidence remains limited. We aim to summarize the presentation and treatment of BCC with orbital invasion to better guide the management of this complex condition.


Assuntos
Carcinoma Basocelular/diagnóstico , Carcinoma Basocelular/terapia , Neoplasias Oculares/diagnóstico , Neoplasias Oculares/terapia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/terapia , Carcinoma Basocelular/patologia , Terapia Combinada , Gerenciamento Clínico , Neoplasias Oculares/patologia , Humanos , Imageamento por Ressonância Magnética , Gradação de Tumores , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Neoplasias Cutâneas/patologia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
10.
Ophthalmic Plast Reconstr Surg ; 31(3): e60-1, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-24801257

RESUMO

Orbital Langerhans cell histiocytosis (LCH) without bone involvement is rare. Isolated involvement of an extraocular muscle without bone change, to the best of the authors' knowledge, has not been previously reported. They describe a unique case of unifocal LCH of the superior oblique muscle with no bone involvement. A 16-year-old girl presented with a 2-week history of diplopia and headache. CT and MRI showed an enlarged right superior oblique muscle with no associated bone involvement. Biopsy with partial debulking revealed LCH and staging confirmed unifocal disease. The lesion underwent complete radiologic resolution following surgery. There was no recurrence after 16 months follow up.


Assuntos
Histiocitose de Células de Langerhans/diagnóstico , Doenças Musculares/diagnóstico , Músculos Oculomotores/patologia , Adolescente , Biópsia , Diplopia/diagnóstico , Feminino , Cefaleia/diagnóstico , Histiocitose de Células de Langerhans/cirurgia , Humanos , Imageamento por Ressonância Magnética , Doenças Musculares/cirurgia , Tomografia Computadorizada por Raios X
11.
Orbit ; 33(6): 449-52, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25207637

RESUMO

We present a first case of 58-year-old man with vision loss in a biopsy-proven idiopathic inflammatory orbital tendon sparing myositis. Tests for thyroid autoantibodies were negative at the initial presentation and at 10-month follow-up period. The diagnosis was confirmed on histopathological examination and was also supported by avid sarcolemmal staining for MHC-1 and MHC-2.


Assuntos
Cegueira/diagnóstico , Músculos Oculomotores/patologia , Miosite Orbital/diagnóstico , Administração Oral , Terapia Combinada , Descompressão Cirúrgica , Glucocorticoides/uso terapêutico , Humanos , Hipertrofia , Infusões Intravenosas , Imageamento por Ressonância Magnética , Masculino , Metilprednisolona/uso terapêutico , Pessoa de Meia-Idade , Miosite Orbital/terapia , Flebografia , Prednisolona/uso terapêutico
12.
Ophthalmic Plast Reconstr Surg ; 30(6): 473-5, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24777266

RESUMO

PURPOSE: To study the hypothesis that in normal patients, changes in eyelid elasticity may occur asymmetrically and in relation to the side on which the individual sleeps. DESIGN: Prospective, consecutive, single-center study within a large, tertiary-referral ophthalmology department within a university hospital. METHODS: This prospective study was carried out consecutively on 262 normal patients. The 3 inclusion criteria were 1) age≥55 years, 2) absence of facial nerve palsy, and 3) absence of eyelid trauma or surgery. Immediately before the ocular plastic surgeon assessed the patient, each patient was questioned in a separate consulting room by the attending orthoptist as to his or her customary side of sleeping. After detailed explanation, the "history-masked" ocular plastic surgeon then assessed the patient's upper eyelid laxity, the main outcome measurement. This was performed by asking the seated patient to look down and then gently grasping the upper eyelids close to the eyelid margin, just medial to the lateral commissure. The ocular plastic surgeon, with thumbs pronated, simultaneously distracted both upper eyelids superiorly, laterally, and anteriorly. The measured separation of the upper eyelid from the globe conjunctiva was obtained using calipers. Eyelid laxity grading was designated as grade 1: 0 to 1.9 mm; grade 2: 2.0 to 3.9 mm; grade 3: 4 to 9 mm; and grade 4: floppy. RESULTS: Two hundred sixty-two patients (58% females) who consecutively satisfied the selection criteria were evaluated, of which 70.22% (183/262) patients had significantly greater laxity of the upper eyelid that corresponded to the side on which they customarily slept. An unpaired t test used to compare the eyelid laxity between the sleeping side and nonsleeping side was statistically significant (p<0.001). CONCLUSION: Normal patients demonstrate a correlation between the side on which they historically or customarily sleep and the laxity of their ipsilateral upper eyelid.


Assuntos
Pálpebras/fisiopatologia , Lateralidade Funcional/fisiologia , Hipotonia Muscular/fisiopatologia , Músculos Oculomotores/fisiopatologia , Sono/fisiologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
13.
Ophthalmic Plast Reconstr Surg ; 30(5): e122-5, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24481505

RESUMO

IgG4-related disease (IgG4-RD) is an inflammatory condition of unknown etiology that can cause tumefactive lesions in a number of tissues and organs, including the orbit and ocular adnexa. Diagnostic criteria for IgG4-RD, including pathology and clinical features and pathology, have been recently proposed. This study presents the first case of unilateral acute visual loss secondary to IgG4-related orbital inflammatory disease with orbital myositis that was complicated by severe compressive optic neuropathy. After initial treatment with pulsed intravenous methylprednisolone, followed by rituximab and radiotherapy, there was a marked improvement in orbital inflammation and clinical and radiological improvement in the compressive optic neuropathy. After 9 months of follow up, the orbital inflammatory disease remained in remission.


Assuntos
Anticorpos Monoclonais Murinos/uso terapêutico , Cegueira/terapia , Descompressão Cirúrgica , Imunoglobulina G/sangue , Fatores Imunológicos/uso terapêutico , Miosite Orbital/complicações , Pseudotumor Orbitário/complicações , Idoso , Antígenos CD20 , Cegueira/etiologia , Terapia Combinada , Humanos , Imageamento por Ressonância Magnética , Masculino , Síndromes de Compressão Nervosa/diagnóstico , Síndromes de Compressão Nervosa/etiologia , Síndromes de Compressão Nervosa/terapia , Doenças do Nervo Óptico/diagnóstico , Doenças do Nervo Óptico/etiologia , Doenças do Nervo Óptico/terapia , Miosite Orbital/diagnóstico , Pseudotumor Orbitário/diagnóstico , Rituximab , Tomografia Computadorizada por Raios X
14.
Artigo em Inglês | MEDLINE | ID: mdl-24398485

RESUMO

PURPOSE: To assess the frequency of simultaneous nasal procedures in powered endoscopic dacryocystorhinostomy performed by oculoplastic surgeons. DESIGN OF STUDY: Retrospective, multicenter study. METHODS: Demographic, clinical, and surgical data of consecutive endoscopic dacryocystorhinostomy cases at 3 oculoplastic centers, over periods of 6, 4, and 2.2 years, respectively, were reviewed. The rates of simultaneous nasal procedures (septoplasty, turbinectomy, and polypectomy) were studied. Complication rates in the patients who had simultaneous endonasal procedures were analyzed. RESULTS: Five hundred seventy-six cases (mean age: 63.2 years [16.2-94 years], women: 67.3%). Of the total cohort of patients, 14.1% required a simultaneous endonasal procedure during endoscopic dacryocystorhinostomy, 11.9% (range among surgeons: 5.2%-15%) required septoplasty, 1.5% required middle turbinate surgery, and 0.34% required polypectomy. Of the 81 patients with concomitant procedures, 1 had postoperative epistaxis, and 1 had an asymptomatic septal adhesion. The anatomical and functional success rates for the entire cohort were 95.6% and 87.8%, respectively. CONCLUSIONS: A significant proportion of patients undergoing endoscopic dacryocystorhinostomy may require concomitant endonasal procedures. Hence, endonasal lacrimal surgeons using techniques that aim to marsupialize the entire lacrimal sac may benefit from expertize in the management of concomitant nasal pathologic study.


Assuntos
Dacriocistorinostomia/métodos , Endoscopia/métodos , Doenças Nasais/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ducto Nasolacrimal/cirurgia , Estudos Retrospectivos , Adulto Jovem
16.
Ophthalmic Plast Reconstr Surg ; 29(6): 417-23, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24217473

RESUMO

PURPOSE: To report 2 patients with apocrine adenocarcinoma of the eyelid and review the literature. DESIGN: Noncomparative, retrospective case series and review. PARTICIPANTS: Clinical data of 2 patients with histopathologic diagnoses of apocrine adenocarcinoma of the eyelid were obtained from medical records. The histopathology and immunohistochemistry data for the 2 cases were studied. A retrospective review was performed on all reported cases of eyelid apocrine carcinoma. MAIN OUTCOME MEASURES: Clinical features, histopathology, immunohistochemistry, and clinical course following treatment are reported. The results of a retrospective review of clinical presentations, local and systemic spread, treatment method, and prognosis from published case reports on eyelid apocrine adenocarcinoma are discussed. RESULTS: One patient had orbital invasion at presentation. This patient had radiotherapy alone and had no systemic or local recurrence at 2 years. One patient underwent a 4-mm margin wide surgical excision. This patient had no local or systemic recurrences at 1 year. A review of the literature suggests that the prognosis of adnexal apocrine tumors is indeterminate and variable. Most patients have successful outcomes following local surgical excision. Radiotherapy has been used as an adjunctive treatment for local metastatic disease. CONCLUSIONS: Apocrine adenocarcinoma is a rare adnexal tumor of the eyelid, which may present with orbital invasion.


Assuntos
Adenocarcinoma/patologia , Glândulas Apócrinas/patologia , Neoplasias Palpebrais/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Adenocarcinoma/terapia , Idoso de 80 Anos ou mais , Neoplasias Palpebrais/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Neoplasias das Glândulas Sudoríparas/terapia
19.
J Cataract Refract Surg ; 36(9): 1453-4, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20692554

RESUMO

We describe a technique of irrigating and thereby rapidly and effectively clearing the cornea of relatively large amounts of surface contaminants that reduce surgical visibility and may contribute to endophthalmitis. This technique is referred to as "macrowash." If the technique is required, it is usually at the commencement of cataract surgery, immediately after placement of the surgical drape. The technique not only saves time, but also reduces the volume of irrigating solution required by the "microwash" technique, which is traditionally carried out by the scrub nurse/surgical assistant using a Rycroft cannula attached to a 15 mL container of irrigating solution.


Assuntos
Extração de Catarata , Córnea/fisiologia , Irrigação Terapêutica/métodos , Acetatos/administração & dosagem , Cateterismo , Combinação de Medicamentos , Humanos , Minerais/administração & dosagem , Cloreto de Sódio/administração & dosagem
20.
Dermatol Clin ; 28(1): 143-52, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19945628

RESUMO

Eye involvement in inherited epidermolysis bullosa (EB) can occur as a spectrum of symptoms and signs. This article describes these signs and symptoms. It also offers options for treatment.


Assuntos
Ambliopia/etiologia , Doenças da Córnea/etiologia , Epidermólise Bolhosa/complicações , Ambliopia/patologia , Ambliopia/terapia , Doenças da Córnea/patologia , Doenças da Córnea/terapia , Epidermólise Bolhosa/patologia , Epidermólise Bolhosa/terapia , Humanos
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