Prevalência e transição para a fragilidade em idosos com alteração cognitiva em uma coorte de um ano / Prevalence and transition to frailty in older adults with cognitive impairment: a 1-year cohort study

Alteração cognitiva e fragilidade são frequentemente encontradas em idosos e parece haver uma relação entre elas. Entretanto, pouco se sabe sobre a prevalência e a transição para a fragilidade nos idosos com alteração cognitiva, principalmente para a população brasileira. O objetivo do estudo foi avaliar a prevalência e a transição entre os estados de fragilidade em um grupo de idosos com alteração cognitiva em uma coorte prospectiva de um ano. Neste estudo de coorte foram avaliados 59 idosos comunitários com alteração cognitiva (≥ 65 anos). O indivíduo frágil foi identificado por apresentar pelo menos três dos seguintes critérios: perda de peso não intencional, fraqueza da força de preensão palmar, exaustão, lentidão na marcha e baixo nível de atividade física. Quando o indivíduo apresentou um ou dois critérios, foi considerado pré-frágil; quando não apresentou nenhum critério, foi considerado não frágil. A função cognitiva foi avaliada pelo Mini Exame do Estado Mental e a gravidade, pela Clinical Dementia Rating Scale. Do total de 59 idosos avaliados na linha de base, 28 (47,5%) eram frágeis, a mesma quantidade era de pré-frágeis e apenas 3 idosos eram não frágeis. Em 12 meses, verificou-se uma transição para fragilidade de 33,3%. Este estudo mostrou que a prevalência de fragilidade é alta entre os idosos com alteração cognitiva e, em um período de 12 meses, novos casos de fragilidade ocorreram entre os idosos com alteração cognitiva. Entretanto, mais estudos são necessários para investigar com melhor precisão uma relação existente entre o declínio cognitivo e a fragilidade

Cognitive impairment and frailty are often found in older people, and they appear to be related to each other. However, little is known about the prevalence and transition to frailty in older adults with cognitive impairment, especially in the Brazilian population. The present study aimed to determine the prevalence and transitions between frailty states in a cohort of older adults with cognitive impairment followed prospectively for 1 year. A cohort of 59 community-dwelling older adults (aged ≥ 65 years) with cognitive impairment was evaluated. Individuals were classified as frail by the presence of 3 or more of the following criteria: unintentional weight loss; reduced grip strength; exhaustion; slowness; and low physical activity level. Individuals meeting 1 or 2 criteria were classified as prefrail, and those meeting 0 criteria as nonfrail. Cognitive function was assessed by the Mini-Mental State Examination, and severity, by the Clinical Dementia Rating scale. Of 59 older adults evaluated at baseline, 28 (47.5%) were classified as frail, 28 (47.5%) as prefrail, and only 3 (5%) as nonfrail. Over 12 months, 33.3% of participants transitioned from prefrail to frail. The present study showed a high prevalence of frailty in older adults with cognitive impairment and, within 12 months, new cases of frailty were identified in this population. Therefore, more research is needed to further investigate the relationship between cognitive decline and frailty.

Frailty and cognitive impairment among community-dwelling elderly.

The aim was to evaluate associations between frailty status and cognitive decline and the incidence of cognitive impairment over 12-month period. Two hundred seven older adults were assessed. Frailty was defined as having at least three of the following criteria: weight loss, weakness, exhaustion, slowness, and low level of activity. Cognitive decline was assessed using the Mini Mental State Examination (MMSE) and Clinical Dementia Rating Scale (CDR). Relative risk (RR) was calculated with a 95% confidence interval (CI). Frailty was associated with subsequent cognitive decline in 12-month when assessed using the MMSE (p=;0.005; RR=;4.6; 95%CI 1.93-11.2). No association was found between frailty and cognitive decline measured by the CDR (p=;0.393; RR=;2.1; 95%CI 0.68-6.7) or between frailty and the incidence of cognitive impairment (p=;0.675; RR=;1.2; 95%CI 0.18-8.3). These findings reveal an association between frailty and subsequent cognitive decline when measured by the MMSE, even within a short period of time.

Frailty and cognitive impairment among community-dwelling elderly / Fragilidade e alteração cognitiva em idosos comunitários

The aim was to evaluate associations between frailty status and cognitive decline and the incidence of cognitive impairment over 12-month period. Two hundred seven older adults were assessed. Frailty was defined as having at least three of the following criteria: weight loss, weakness, exhaustion, slowness, and low level of activity. Cognitive decline was assessed using the Mini Mental State Examination (MMSE) and Clinical Dementia Rating Scale (CDR). Relative risk (RR) was calculated with a 95% confidence interval (CI). Frailty was associated with subsequent cognitive decline in 12-month when assessed using the MMSE (p=0.005; RR=4.6; 95%CI 1.93–11.2). No association was found between frailty and cognitive decline measured by the CDR (p=0.393; RR=2.1; 95%CI 0.68–6.7) or between frailty and the incidence of cognitive impairment (p=0.675; RR=1.2; 95%CI 0.18–8.3). These findings reveal an association between frailty and subsequent cognitive decline when measured by the MMSE, even within a short period of time.

O objetivo foi avaliar a associação entre fragilidade e o declínio cognitivo e a incidência de alteração cognitiva, em 12 meses. Foram avaliados 207 idosos. Fragilidade foi definida como ter pelo menos três dos critérios: perda de peso, fraqueza, exaustão, lentidão e baixo nível de atividade. O declínio cognitivo foi avaliado pelo Mini Exame do Estado Mental (MEEM) e pela Escala Clínica de Demência (CDR). Foi calculado o risco relativo (RR) com intervalo de confiança (IC) de 95%. A fragilidade está associada a um declínio subsequente da função cognitiva em 12 meses, quando medida pelo MEEM (p=0,005; RR=4,6; IC95% 1,93–11,2). Não foi verificada associação entre fragilidade e o declínio da função cognitiva pela CDR (p=0,393; RR=2,1; IC95% 0,68–6,7) e entre a fragilidade e a incidência da alteração cognitiva (p=0,675; RR=1,2; IC95% 0,18–8,3). Este estudo mostrou que, mesmo em um período curto, existe associação entre a fragilidade e um declínio subsequente da função cognitiva, quando medida pelo MEEM.

Força de preensão palmar em idosos com demência: estudo da confiabilidade / Handgrip strength in elderly with dementia: study of reliability

CONTEXTUALIZAÇÃO: Instrumentos de medida devem ser analisados quanto a sua utilidade clínica e científica em diferentes populações. Apesar de o teste da força de preensão palmar (FPP) ser amplamente utilizado, pouco foi investigado quanto a sua confiabilidade ao ser utilizado em idosos com demência e em qual grau de demência seria inviabilizado o seu uso. OBJETIVO: Avaliar a confiabilidade teste-reteste da FPP em idosos com diferentes graus de demência. MÉTODO: Realizou-se uma avaliação dos aspectos cognitivos de 76 idosos com demência e uma entrevista com o cuidador, permitindo a classificação do idoso segundo os critérios da Escala Clínica de Demência (Clinical dementia rating - CDR). Para essas avaliações, foram utilizados o Miniexame do Estado Mental e os questionários Pfeffer, Lawton e Katz. Vinte idosos foram classificados como grau questionável (83,4±5,8 anos); 19, como leve (82,4±6,8 anos); 19, como moderado (85,8±5,6 anos) e 18, como grave (84,0±5,1 anos). Os idosos tiveram a FPP avaliada por meio de um dinamômetro hidráulico JAMAR e, após uma semana, foram reavaliados. A confiabilidade foi estimada pelo Coeficiente de Correlação Intraclasse (ICC). O nível de significância foi α=0,05. RESULTADOS: A confiabilidade teste-reteste foi excelente para os grupos que apresentaram o CDR questionável (ICC=0,975; p=0,001), leve (ICC=0,968; p=0,002) e moderado (ICC=0,964; p=0,001). A análise do grupo com CDR grave mostrou não haver uma significância estatística e um ICC baixo (ICC=0,415; p=0,376). CONCLUSÃO: O teste de FPP apresenta excelente confiabilidade ao ser utilizado em idosos com demências questionável, leve e moderada, viabilizando seu uso em pesquisas. Já em idosos classificados como graves, seu uso não é recomendado visto que a confiabilidade da medida é baixa e, portanto, sem relevância clínica para uso na prática.

BACKGROUND: Measuring instruments should have their scientific and clinical value evaluated in different populations. The handgrip strength test is widely used, however little has been investigated about its reliability when used in elderly with dementia and the right stage wich its use should be avoided. OBJECTIVES: To evaluate the test-retest reliability of the handgrip strength test in elderly with different ratings of dementia. METHOD: The cognitive function of 76 elderly subjects with dementia was measured, and the caregivers were interviewed to allow classification by the Clinical dementia rating (CDR). For these assessments the Mini-Metal State Examination and the Pfeffer, Lawton, and Katz scales were used. Twenty subjects were classified as borderline (83.4± 5.8 years), 19 as mild (82.4±6.8 years), 19 as moderate (85.8±5.6 years) and 18 as severe dementia (84.0±5.1 years). Handgrip strength was assessed with a JAMAR hydraulic dynamometer and after one week it was reevaluated. Reliability was analyzed by Intraclass Correlation Coefficient (ICC). The significance level was set at α=0.05. RESULTS: Test-retest reliability was excellent for groups with borderline (ICC=0.975; p=0.001), mild (ICC=0.968; p=0.002), and moderate (ICC=0.964; p=0.001) dementia. The analysis of the group with a severe CDR showed no statistical significance and a low ICC (ICC=0.415; p=0.376). CONCLUSION: The handgrip strength test has excellent reliability when used in elderly with borderline, mild, and moderate dementia, which enables its use in research. However, its use is not recommended in elderly classified with severe dementia due to the measure’s low reliability and subsequent irrelevance in clinical practice.

Handgrip strength in elderly with dementia: study of reliability.

BACKGROUND: Measuring instruments should have their scientific and clinical value evaluated in different populations. The handgrip strength test is widely used, however little has been investigated about its reliability when used in elderly with dementia and the right stage wich its use should be avoided. OBJECTIVES: To evaluate the test-retest reliability of the handgrip strength test in elderly with different ratings of dementia. METHOD: The cognitive function of 76 elderly subjects with dementia was measured, and the caregivers were interviewed to allow classification by the Clinical dementia rating (CDR). For these assessments the Mini-Metal State Examination and the Pfeffer, Lawton, and Katz scales were used. Twenty subjects were classified as borderline (83.4±5.8 years), 19 as mild (82.4±6.8 years), 19 as moderate (85.8±5.6 years) and 18 as severe dementia (84.0±5.1 years). Handgrip strength was assessed with a JAMAR hydraulic dynamometer and after one week it was reevaluated. Reliability was analyzed by Intraclass Correlation Coefficient (ICC). The significance level was set at α=0.05. RESULTS: Test-retest reliability was excellent for groups with borderline (ICC=0.975; p=0.001), mild (ICC=0.968; p=0.002), and moderate (ICC=0.964; p=0.001) dementia. The analysis of the group with a severe CDR showed no statistical significance and a low ICC (ICC=0.415; p=0.376). CONCLUSION: The handgrip strength test has excellent reliability when used in elderly with borderline, mild, and moderate dementia, which enables its use in research. However, its use is not recommended in elderly classified with severe dementia due to the measure's low reliability and subsequent irrelevance in clinical practice.

Reliability of transverse plane pelvic alignment measurement during the bridge test with unilateral knee extension.

BACKGROUND: The bridge test with unilateral knee extension evaluates the stability of the trunk and pelvis. The evaluation of this stability can contribute to the understanding of the occurrence of musculoskeletal injuries. OBJECTIVES: To investigate the intra- and inter-rater reliability of a qualitative analysis and intra-test reliability of a quantitative analysis of transverse plane pelvic alignment during the bridge test with unilateral knee extension. METHOD: Thirty participants (24.73±4.24 years old) were tested. The qualitative analysis was conducted by asking two raters to judge the transverse plane pelvic alignment and its reliability was assessed with the weighted kappa coefficient (k(w)). The quantitative analysis was conducted by measuring the greatest pelvic tilt angle in transverse plane and its reliability was assessed by use of the intraclass correlation coefficient (ICC); the mean change, which was evaluated using 95% confidence interval of the mean difference (95%CI d) and Bland-Altman plot; and the quantification of measurement variability, which was assessed using standard error of measurement (SEM) and the coefficient of variation of the typical error (CVTE). In addition, the minimal detectable change (MDC95) was determined. RESULTS: The intra-rater reliability ranged from fair to moderate (k(w)=0.32 to 0.58) and the inter-rater reliability was substantial (k(w)=0.80). The intra-test reliability was excellent (ICC=0.82), the 95%CI d ranged from -0.51º to 1.99º, the SEM was 2.38° and the CV(TE) was 28.75%. The MDC95 was 6.59°. CONCLUSIONS: The inter-rater reliability was greater than the intra-rater reliability; the intra-test reliability was excellent and showed no systematic or random error.

Confiabilidade da mensuração do alinhamento pélvico no plano transverso durante o teste da ponte com extensão unilateral do joelho / Reliability of transverse plane pelvic alignment measurement during the bridge test with unilateral knee extension

CONTEXTUALIZAÇÃO: O teste da ponte com extensão unilateral do joelho avalia a estabilidade de tronco e pelve. A avaliação dessa estabilidade pode contribuir para o entendimento da ocorrência de lesões musculoesqueléticas. OBJETIVOS: Investigar a confiabilidade intra e interexaminador de uma análise qualitativa e a confiabilidade intrateste de uma análise quantitativa do alinhamento pélvico no plano transverso durante o teste da ponte com extensão unilateral do joelho. MÉTODO: Foram avaliados 30 participantes (24,73±4,24 anos). A análise qualitativa foi realizada pelo julgamento do alinhamento pélvico no plano transverso por dois examinadores, e sua confiabilidade determinada pelo Coeficiente Kappa Ponderado (k w). A análise quantitativa foi realizada pela medida do maior ângulo de desalinhamento pélvico no plano transverso e a confiabilidade determinada pelo Coeficiente de Correlação Intraclasse (CCI); pela análise da mudança na média dos dados, utilizando-se o intervalo de confiança de 95% da média da diferença (95%IC ) e método de Bland-Altman; pelo dimensionamento da variabilidade entre medidas, considerando-se o erro-padrão da medida combinado (EPM) e coeficiente de variação do erro típico (CV ET). Além disso, verificou-se a mudança mínima detectável (MMD95). RESULTADOS: A confiabilidade intraexaminador variou de razoável a moderada (k w=0,32-0,58) e a confiabilidade interexaminador foi substancial (k w=0,80). A confiabilidade intrateste foi excelente (CCI=0,82) e apresentou o IC95% de -0,51º a 1,99º, EPM de 2,38º e o CV ET de 28,75%. O MMD95 foi de 6,59º. CONCLUSÕES: O índice de confiabilidade interexaminador foi superior ao intraexaminador, a confiabilidade intrateste foi excelente e não apresentou erro sistemático e aleatório.

BACKGROUND: The bridge test with unilateral knee extension evaluates the stability of the trunk and pelvis. The evaluation of this stability can contribute to the understanding of the occurrence of musculoskeletal injuries. OBJECTIVES: To investigate the intra- and inter-rater reliability of a qualitative analysis and intra-test reliability of a quantitative analysis of transverse plane pelvic alignment during the bridge test with unilateral knee extension. METHOD: Thirty participants (24.73±4.24 years old) were tested. The qualitative analysis was conducted by asking two raters to judge the transverse plane pelvic alignment and its reliability was assessed with the weighted kappa coefficient (k w). The quantitative analysis was conducted by measuring the greatest pelvic tilt angle in transverse plane and its reliability was assessed by use of the intraclass correlation coefficient (ICC); the mean change, which was evaluated using 95% confidence interval of the mean difference (95%CI ) and Bland-Altman plot; and the quantification of measurement variability, which was assessed using standard error of measurement (SEM) and the coefficient of variation of the typical error (CV TE). In addition, the minimal detectable change (MDC95) was determined. RESULTS: The intra-rater reliability ranged from fair to moderate (k w=0.32 to 0.58) and the inter-rater reliability was substantial (k w=0.80). The intra-test reliability was excellent (ICC=0.82), the 95% CI ranged from -0.51º to 1.99º, the SEM was 2.38º and the CV TE was 28.75%. The MDC95 was 6.59º. CONCLUSIONS: The inter-rater reliability was greater than the intra-rater reliability; the intra-test reliability was excellent and showed no systematic or random error.

Clinical course of 822 children with prenatally detected nephrouropathies.

BACKGROUND AND OBJECTIVES: With the advent of fetal screening ultrasonography, the detection of congenital anomalies of the kidney and urinary tract (CAKUT) in utero has permitted early management of these conditions. This study aims to describe the clinical course of a large cohort of patients with prenatally detected nephrouropathies. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this retrospective cohort study, 822 patients were prenatally diagnosed with CAKUT and systematically followed up at a tertiary Renal Unit for a median time of 43 months. Variables included in the analysis were sex, laterality, fetal ultrasonography (isolated versus associated hydronephrosis), and presence/absence of nephrouropathies. The events of interest were urinary tract infection, surgical interventions, hypertension, CKD, and death. Survival analyses were performed to evaluate time until occurrence of the events of interest. RESULTS: Urinary tract infection occurred in 245 (29.8%) children, with higher risk in females (hazard ratio=1.30, 95% confidence interval=1.02-1.70, P=0.05); 22 patients (2.7%) had hypertension, and 49 (6%) patients developed CKD. The risk of CKD was greater in patients with associated hydronephrosis (hazard ratio=5.20, 95% confidence interval=2.90-9.30, P<0.001). Twelve patients (1.5%) died during follow-up. Death was significantly associated with being born during the first period of the study (hazard ratio=6.00, 95% confidence interval=1.60-22.50, P<0.001), associated hydronephrosis (hazard ratio=9.30, 95% confidence interval=2.90-29.30, P<0.001), and CKD (hazard ratio=170.00, 95% confidence interval=41.00-228.00, P<0.001). CONCLUSIONS: In our series, the clinical course of prenatally detected CAKUT was heterogeneous, and those infants with associated hydronephrosis at baseline were identified as a high-risk subgroup.

Effect of different ingredients contents on physical, physicochemical and sensory properties of the creamy banana marmalade cv. ‘nanica(Musa cavendishii)

Banana is a highly perishable fruit, with a shelf life of 7 to 10 days, and the fruits being in excess or those in non conformity to be consumed are used to produce marmalade; and it is an interesting economic alternative. This study evaluated the effect of different ingredients on the physical, physicochemical and sensory properties of creamy banana marmalade. An incomplete factorial design (24-1) with two levels of four factors (pulp/sugarratio, pectin concentration, added amount of acid and sorbate concentration). The sensorial acceptance of marmalades was evaluated using a 9-point hedonic scale, and the purchase intention by employing a 5-pointscale. The analyzed variables mostly affecting the parameters were the pulp/sugar ratio, the added amount of acid and the sorbate concentration, due to their reaction with the marmalade components. The formulation 2 was preferred by consumers because of the firmest texture and the intensified yellow color.(AU)

Effect of different ingredients contents on physical, physicochemical and sensory properties of the creamy banana marmalade cv. ‘nanica’(Musa cavendishii)

Banana is a highly perishable fruit, with a shelf life of 7 to 10 days, and the fruits being in excess or those in non conformity to be consumed are used to produce marmalade; and it is an interesting economic alternative. This study evaluated the effect of different ingredients on the physical, physicochemical and sensory properties of creamy banana marmalade. An incomplete factorial design (24-1) with two levels of four factors (pulp/sugarratio, pectin concentration, added amount of acid and sorbate concentration). The sensorial acceptance of marmalades was evaluated using a 9-point hedonic scale, and the purchase intention by employing a 5-pointscale. The analyzed variables mostly affecting the parameters were the pulp/sugar ratio, the added amount of acid and the sorbate concentration, due to their reaction with the marmalade components. The formulation 2 was preferred by consumers because of the firmest texture and the intensified yellow color.