RESUMO
Background and Objectives: Every year, suicide accounts for approximatelyone million preventable deaths worldwide. Suicidal behavior is complex andmulti-determined with risk factors identified in multiple domains including clinical, genetic,environmental, behavioral, neurophysiological, and neurocognitive. Modelingcausal pathways that integrate these factors may assist in better identification of high-riskindividuals would allow for effective preventive intervention.Methods: Published literature in the English language was reviewed to identify evidencesupporting a multi-dimensional model of putative causal pathways for suicidal behavior.Results: There is evidence that clinical, neurochemical, neuroendocrine, neurocognitive,and neurophysiological contributory factors may be useful as intermediate phenotypes in describingputative causal pathways from genetics and early-life adversity to suicidal acts.Conclusions: Determining the causes of suicidal behavior involves integrating risk factorsfrom multiple domains (AU)
