Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica , Doença de Hodgkin/terapia , Adolescente , Adulto , Criança , Ciclofosfamida/uso terapêutico , Quimioterapia Combinada , Feminino , Doença de Hodgkin/tratamento farmacológico , Humanos , Masculino , Mecloretamina/uso terapêutico , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/tratamento farmacológico , Recidiva Local de Neoplasia/terapia , Prednisona/uso terapêutico , Procarbazina/uso terapêutico , Dosagem Radioterapêutica , Esplenectomia , Vincristina/uso terapêuticoAssuntos
Doença de Hodgkin/radioterapia , Aceleradores de Partículas , Lesões por Radiação/etiologia , Radioterapia de Alta Energia/efeitos adversos , Doença Aguda , Adolescente , Adulto , Idoso , Feminino , Doença de Hodgkin/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Dosagem RadioterapêuticaRESUMO
The betatron B5M25 bremsstrahlung is formed only by a rectangularly shaped diaphragm, which results in excessive irradiation of healthy tissues surrounding the pathological focus. An appliance in the form of an additional diaphragm with inserted shaped units (blocks) fastened to the proper betatron diaphragm and permitting formation of a dose field in conformity with the pathological focus outlines has been constructed. The design of the appliance helps avoid "contamination" of the bremsstrahlung beam with electrons and second generation Compton quanta.
Assuntos
Radioterapia de Alta Energia/instrumentação , Dosagem Radioterapêutica , U.R.S.S.RESUMO
Since 1963 to 1975 one hundred and eighty eight patients were subjected to surgery with preoperative irradiation, using a betatron of 25 M. e. v. Irradiation was carried on during 2--3 weeks from 2 or 3 fields daily. A total focal dose ranged within the limits from 2500 to 4500 rad. Radical operations were performed in 159 patients, the mortality being 6.7%. The survival over 3 years--in 69.1%, over 5 years--in 57.3%. Postoperative irradiation using a betatron of 25 M. e. v. is found to contribute to an improvement of general condition in lung cancer patients and to render a positive effect on clinical and roentgenological signs of the disease. A comparative morphological study of diagnostic biopsy specimens and lung preparations, removed following irradiation, indicates various degree of cancer pathomorphosis up to tumor disappearrance and development of radiation sclerosis.