[Effectiveness of treatment of recurrences of non-Hodgkin's lymphoma after combined chemoradiotherapy depending on prognostic indicators]. / Effektivnost' lecheniia retsidivov nekhodzhkinskikh limfom posle kombinirovannoi khimioluchevoi terapii v zavisimosti ot prognosticheskikh priznakov.

The results were evaluated of the management of non-Hodgkin's lymphomas in 46 out of 150 patients relapsing after first complete remission, following early-stage chemoradiotherapy. Polychemotherapy of recurrent tumors was given to 85% (39/46), repeat combined treatment--13% (6/46) and radiotherapy--2% (1/46). Remission was reported in 91% (42/46): complete--69% (32) and partial--22% (10). Remission frequency and duration directly depended on degree of risk (IPI), stage of recurrence development and advancement, tumor size and general symptoms of intoxication. There was no relationship between frequency and duration, on the one hand, and sex and age, tumor pattern or number of involvement areas, on the other. Instead, the efficacy was influenced by the general condition of the patient, damage to the lymph nodes rather than adjacent areas as well as number of such areas. LDH blood level impacted the end results.

[The prolymphocytic-lymphocytic leukemization of B-cell lymphosarcomas]. / Prolimfotsitarno-limfotsitarnaia leikemizatsiia B-kletochnykh limfosarkom.

The paper presents clinical, hematological, morphological and immunological characteristics of B-cell lymphosarcoma with prolymphocytic-lymphocytic type of leukemization in 50 adult patients (9 females and 41 males aged 29-86 years). In B-cell immunological subvariant of prolymphocytic-lymphocytic leukemization changes in the primary tumor always corresponded to prolymphocytic variant of lymphosarcoma. This distinguishes B-cell lymphosarcomas from previously described T-cellular ones in which the type of eventual leukemic changes did not always correspond to the kind of initial tumor. The presence or absence of prolymphocytes with split nuclei in bone marrow puncture samples was neither of clinical nor of prognostic significance. In leukemization of B-cell prolymphocytic lymphosarcoma from the cells with split nuclei or cells with different configuration of the nuclei, immunological phenotype typical for B-cell chronic lymphoid leukemia did not occur. In prolymphocytic lymphosarcoma from cells with round nuclei one-third of patients had immunological phenotype more typical for B-cell chronic lymphoid leukemia. However, among them were patients with aggressive course with predominant extranodal location of tumor and prolymphocytic type of leukemization. Tumor nodes in B-cell prolymphocytic lymphosarcomas, irrespective of leukemization morphological variant, proved rather resistant to therapy. A complete clinicohematological remission according to the international criteria occurred in 2 of 50 patients, only.

[The results of the combined chemoradiation treatment of lymphosarcomas corresponding to the degree of its intensity]. / Rezul'taty kombinirovannogo khimioluchevogo lecheniia limfosarkom sootvetstvenno stepeni ego intensivnosti.

The authors describe the results of combined chemoradiotherapy of different intensity in 117 patients. It has been discovered that the differences in the results obtained were dependent on the stage of the treatment at which there ensured remissions rather than on the treatment intensity. The more rapidly complete remissions were attained the better were the long-term results, for the treatment continued during remissions turned out consolidating.

[Pathologic anatomy of subtypes of immunoblastic lymphosarcoma]. / O patologicheskoi anatomii podvariantov immunoblastnoi limfosarkomy.

Morphological parameters for immunoblastic lymphosarcoma (IL) subtypes: plasmocytic IL (PIL) and polymorphocellular IL (PMIL) were determined through a comparative morphological analysis of 56 sections and 64 respective diagnostic biopsies. PIL was found to more frequently affect the gastrointestinal tract. Tumors were found to be selective in damaging the organs, e.g. white pulp was affected in PIL, marginal follicular areas, in PMIL. Clinical and anatomical analyses of the death causes in patients with IL showed that they all had died of neoplastic progression (67.9%), concurrent diseases (23.2%) or complications resulted from the therapy performed (8.9%) upon tumor progression.

[Extramedullary manifestations of blast crisis in chronic myeloleukemia]. / Ekstramedulliarnye proiavleniia blastnogo kriza khronicheskogo mieloleikoza.

The paper is concerned with the development of extramedullary blast infiltrates in Ph-positive chronic myeloid leukemia. Two cases are described. In one case during the blastic phase lasting 27 months, a female patient developed by turn skin leukemids, lesions of the soft tissues in the knee joint, lesions of the stomach, lungs and heart. Administration of the treatment according to the "3 + 7" scheme (an anthracycline antibiotic plus cytosar) and to the TRAMPCOL scheme brought about the reverse development of the infiltrates. In the second case a male patient in the 12th year of the disease developed, in the absence of the blastic phase, massive blast lesions of the lymph nodes of the mediastinum followed by neuroleukemia. The lesions were removed by the treatment according to the ACOP scheme and endolumbal injections of methotrexate and cytosar. Ten months after diagnosing the enlargement of the lymph nodes of the mediastinum the picture of the blood and the bone marrow remained typical of the marked stage of the disease. The authors provide brief data on 27 patients with extramedullary blast infiltrates in the terminal stage of chronic myeloid leukemia together with short reported data.

[Pathological anatomy of Lennert's lymphoma]. / K patologicheskoi anatomii limfomy Lennerta.

Characterization of Lennert's lymphoma morphological substrate is given on the basis of analysis of 32 biopsies (from 22 patients) and 6 autopsy cases studied histologically, histochemically and immunomorphologically. Morphological features of a progressing disease and transformation into the immunoblastic lymphosarcoma are described. The "prelymphomatous" nature of Lennert's lymphoma is suggested taking into consideration morphofunctional characteristics of the infiltrate cells, transitory properties of peculiar morphological changes and a frequent outcome into the immunoblastic lymphosarcoma of a B-cell genesis.

[Ambulatory chemotherapy of hematosarcoma]. / Ambulatornaia khimioterapiia gematosarkom.

The results of outpatient polychemotherapy of 102 out of 120 patients with hematosarcoma are discussed. The outpatient treatment of hematosarcoma was found as effective as in hospital. The best results were registered in application of VAMP (vincristine, methotrexate, 6-mercaptopurine and prednisolone) and COP (cyclophosphamide, vincristine or oncovin and prednisolone) schemes--complete remission was observed in 50.0 and 32.9% of cases, respectively. Outpatient chemotherapy of hematosarcoma offers advantages since it may be given to larger numbers of patients. Side-effects and complication of chemotherapy appeared to be slight and unstable.