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Menopause ; 14(2): 251-60, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17194962

RESUMO

OBJECTIVE: 17beta-estradiol (E2) negatively modulates neointima formation, leukocyte infiltration, and proinflammatory mediator expression after vascular injury in young (10-wk-old) ovariectomized (OVX) rats. Trials of E2 in elderly postmenopausal women have not confirmed a vasoprotective effect. This study tested the hypothesis that responsiveness to E2 is lost in injured arteries of aged (12-mo-old) OVX rats. DESIGN: E2- or vehicle-treated OVX rats underwent balloon injury of the carotid artery and were killed after 2 weeks for morphometric examination of arteries, after 24 hours for assessment of leukocyte infiltration, and after 2 hours for quantification of proinflammatory mediator mRNA expression. RESULTS: Neointima formation was significantly reduced in aged compared with young vehicle-treated rats. E2 treatment had directionally opposite effects on intima/media ratios in aged (+75%) and young (-40%) rats. Injury induced increases in infiltrating total leukocytes, neutrophils, monocytes/macrophages, and expression of proinflammatory mediators in arteries of aged rats; E2 had no effect on these inflammatory responses to injury. Estrogen receptor alpha and beta protein expression were similar in carotid arteries of young and aged rats on immunofluorescence testing. CONCLUSIONS: Aged OVX rats lose the vasoprotective and anti-inflammatory responses to exogenous E2 seen in younger animals. These results may be relevant to the lack of vasoprotection observed in outcome trials of estrogen therapy in postmenopausal women.


Assuntos
Lesões das Artérias Carótidas/prevenção & controle , Quimiotaxia de Leucócito/efeitos dos fármacos , Estradiol/farmacologia , Mediadores da Inflamação/metabolismo , Envelhecimento , Animais , Lesões das Artérias Carótidas/patologia , Modelos Animais de Doenças , Estradiol/administração & dosagem , Estradiol/uso terapêutico , Receptor alfa de Estrogênio/metabolismo , Receptor beta de Estrogênio/metabolismo , Feminino , Leucócitos/efeitos dos fármacos , Ovariectomia , Ratos
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