RESUMO
The persistence of immunoglobulin M (IgM) antibody to Toxoplasma gondii in sera from 38 patients after toxoplasmic lymphadenopathy was investigated by using an indirect immunofluorescence assay, a double-sandwich enzyme-linked immunosorbent assay, and an immunosorbent agglutination assay. Positive predictive values at 3 and 6 months after lymphadenopathy were, respectively, 45 and 73% for the indirect immunofluorescence assay, 25 and 45% for the double-sandwich enzyme-linked immunosorbent assay, and 22 and 43% for the immunosorbent agglutination assay.
Assuntos
Imunoglobulina M/análise , Doenças Linfáticas/diagnóstico , Toxoplasma/imunologia , Toxoplasmose/diagnóstico , Adolescente , Adulto , Animais , Anticorpos Antiprotozoários/análise , Anticorpos Antiprotozoários/biossíntese , Ensaio de Imunoadsorção Enzimática , Feminino , Imunofluorescência , Seguimentos , Humanos , Imunoglobulina M/biossíntese , Técnicas de Imunoadsorção , Doenças Linfáticas/imunologia , Masculino , Valor Preditivo dos Testes , Toxoplasmose/imunologiaRESUMO
Cerebrospinal fluid (CSP) glucose values were measured in 37 HIV-positive patients with neurologic symptoms and in 35 HIV-negative controls affected by bacterial or viral meningo-encephalitis (ME). Low CSF glucose values were found more frequently in HIV+ patients (49% of cases) than in ME patients (14%). CSF/serum ratios for glucose were also significantly lower in HIV +. Mean serum glucose did not differ between the two groups. Since HIV is a strongly neurotropic and infects early the endothelial cells of the brain capillaris, where glucose is actively carried from plasma to CSP, it is hypothesized that low CSF glucose in HIV-infected patients with neurological symptoms might be an early sign of CNS invasion by the virus.
