RESUMO
Melanomas in the anatomically complex area of the head and neck impose formidable obstacles to treatment. Mucosal melanomas, for reasons which remain uncertain, are associated with a poorer prognosis. Because no systemic treatment is known to be effective, increased awareness by patients and a high index of suspicion is warranted. The disease is potentially curable if diagnosed and treated at an early stage.
Assuntos
Neoplasias Labiais , Melanoma , Evolução Fatal , Humanos , Neoplasias Labiais/diagnóstico , Neoplasias Labiais/patologia , Neoplasias Labiais/terapia , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/secundário , Neoplasias Pulmonares/terapia , Masculino , Melanoma/diagnóstico , Melanoma/secundário , Melanoma/terapia , Pessoa de Meia-Idade , Estadiamento de NeoplasiasRESUMO
One hundred and seventy-eight cases of squamous cell carcinoma of the head and neck were reviewed. The incidence of second malignant neoplasms was 15%. The authors conclude that environmental and life-style factors contributed to the development of a second malignancy.
Assuntos
Carcinoma de Células Escamosas/epidemiologia , Neoplasias de Cabeça e Pescoço/epidemiologia , Adulto , Idoso , Humanos , Incidência , Iowa/epidemiologia , Pessoa de Meia-Idade , Segunda Neoplasia Primária/epidemiologia , Estudos RetrospectivosRESUMO
This very unusual case involves a 70-year-old white male who was within 50 miles of atomic bomb testing in the Mohave Desert and had 56 primary malignancies from 1946 to 1992. Major cytogenetic abnormalities sometimes found in patients with apparent genetic susceptibility for developing solid tumors are reviewed.
