Mn-Mediated Direct Regioselective C-H Trifluoromethylation of Imidazopyridines and Quinoxalines.

A simple and highly efficient strategy has been developed for direct C-H trifluoromethylation at C-3 of imidazopyridines and C-8 of quinoxalines with readily available Langlois reagent through KMnO4/AcOH system. This protocol showed broad substrate scope and afforded moderate-to-excellent yields of both products. It is the first report that the functionalization of quinoxalines occurred regioselectively at the C-8 position of quinoxalines. Mechanistic studies revealed that reaction proceeded via radical pathway.