Investigating the neural mechanisms of transcranial direct current stimulation effects on human cognition: current issues and potential solutions.

Transcranial direct current stimulation (tDCS) has been studied extensively for its potential to enhance human cognitive functions in healthy individuals and to treat cognitive impairment in various clinical populations. However, little is known about how tDCS modulates the neural networks supporting cognition and the complex interplay with mediating factors that may explain the frequently observed variability of stimulation effects within and between studies. Moreover, research in this field has been characterized by substantial methodological variability, frequent lack of rigorous experimental control and small sample sizes, thereby limiting the generalizability of findings and translational potential of tDCS. The present manuscript aims to delineate how these important issues can be addressed within a neuroimaging context, to reveal the neural underpinnings, predictors and mediators of tDCS-induced behavioral modulation. We will focus on functional magnetic resonance imaging (fMRI), because it allows the investigation of tDCS effects with excellent spatial precision and sufficient temporal resolution across the entire brain. Moreover, high resolution structural imaging data can be acquired for precise localization of stimulation effects, verification of electrode positions on the scalp and realistic current modeling based on individual head and brain anatomy. However, the general principles outlined in this review will also be applicable to other imaging modalities. Following an introduction to the overall state-of-the-art in this field, we will discuss in more detail the underlying causes of variability in previous tDCS studies. Moreover, we will elaborate on design considerations for tDCS-fMRI studies, optimization of tDCS and imaging protocols and how to assure high-level experimental control. Two additional sections address the pressing need for more systematic investigation of tDCS effects across the healthy human lifespan and implications for tDCS studies in age-associated disease, and potential benefits of establishing large-scale, multidisciplinary consortia for more coordinated tDCS research in the future. We hope that this review will contribute to more coordinated, methodologically sound, transparent and reproducible research in this field. Ultimately, our aim is to facilitate a better understanding of the underlying mechanisms by which tDCS modulates human cognitive functions and more effective and individually tailored translational and clinical applications of this technique in the future.

Control in context: The theta rhythm provides evidence for reactive control but no evidence for proactive control.

A prime goal of psychological science is to understand how humans can flexibly adapt to rapidly changing contexts. The foundation of this cognitive flexibility rests on contextual adjustments of cognitive control, which can be tested using the list-wide proportion congruency effect (LWPC). Blocks with mostly incongruent (MI) trials show smaller conflict interference effects compared to blocks with mostly congruent (MC) trials. A critical debate is how proactive and reactive control processes drive contextual adjustments. In this preregistered study (N = 30), we address this conundrum, by using the theta rhythm as a key neural marker for cognitive control. In a confound-minimized Stroop paradigm with short alternating MC and MI blocks, we tested reaction times, error rates, and participants' individualized theta activity (2-7 Hz) in the scalp-recorded electroencephalogram. An LWPC effect was found for both, reaction times and error rates. Importantly, the results provided clear evidence for reactive control processes in the theta rhythm: Theta power was higher in rare incongruent compared with congruent trials in MC blocks, but there was no such modulation in MI blocks. However, regarding proactive control, there were no differences in sustained theta power between MC and MI blocks. A complementary analysis of the alpha activity (8-14 Hz) also revealed no evidence for sustained attentional resources in MI blocks. These findings suggest that contextual adjustments rely mainly on reactive control processes in the theta rhythm. Proactive control, in the present study, may be limited to a flexible attentional shift but does not seem to require sustained theta activity.

EXPRESS: The affective consequences of response inhibition determine no-go based crosstalk effects in dual tasks.

Backward crosstalk effects (BCE) are observed in dual-task studies when characteristics of Task 2 influence Task 1 performance. When Task 2 is a go/no-go task, responses in Task 1 are slower when Task 2 is a no-go as compared to a go trial. This no-go BCE has been argued to be due to response inhibition spilling over from Task 2 to Task 1. Growing evidence shows that response inhibition elicits negative affect leading to affective devaluation of associated stimuli. We tested for a functional role of the negative affective consequence of response inhibition in the no-go BCE by investigating its interaction with affective processing in Task 1. In four experiments, Task 1 was a valence categorization task, and Task 2 a go/no-go task. In all experiments, the no-go BCE strongly depended on affective processing in Task 1. While this modulation could be attributed to an affective (mis)match between stimulus features in both tasks in Experiments 1 and 2, Experiments 3 and 4 provided evidence for an affective (mis)match between stimulus valence in Task 1 and affective consequences of Task 2 response inhibition. Results are discussed in the context of current theories of no-go BCE in dual tasks.

Transfer of task-probability-induced biases in parallel dual-task processing occurs in similar, but is constraint in distinct task sets.

Although humans often multitask, little is known about how the processing of concurrent tasks is managed. The present study investigated whether adjustments in parallel processing during multitasking are local (task-specific) or global (task-unspecific). In three experiments, participants performed one of three tasks: a primary task or, if this task did not require a response, one of two background tasks (i.e., prioritized processing paradigm). To manipulate the degree of parallel processing, we presented blocks consisting mainly of primary or background task trials. In Experiment 1, the frequency manipulation was distributed equally across the two background tasks. In Experiments 2 and 3, only one background task was frequency-biased (inducer task). The other background task was presented equally often in all blocks (diagnostic task) and served to test whether processing adjustments transferred. In all experiments, blocks with frequent background tasks yielded stronger interference between primary and background tasks (primary task performance) and improved background task performance. Thus, resource sharing appeared to increase with high background task probabilities even under triple task requirements. Importantly, these adjustments generalized across the background tasks when they were conceptually and visually similar (Experiment 2). Implementing more distinct background tasks limited the transfer: Adjustments were restricted to the inducer task in background task performance and only small transfer was observed in primary task performance (Experiment 3). Overall, the results indicate that the transfer of adjustments in parallel processing is unrestricted for similar, but limited for distinct tasks, suggesting that task similarity affects the generality of resource allocation in multitasking. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

When a smile is still a conflict: Affective conflicts from emotional facial expressions of ingroup or outgroup members occur irrespective of the social interaction context.

Facial expressions play a crucial role in human interactions. Typically, a positive (negative) expression evokes a congruent positive (negative) reaction within the observer. This congruent behavior is inverted, however, when the same positive (negative) expression is displayed by an outgroup member. Two approaches provide an explanation for this phenomenon. The social intentions account proposes underlying social messages within the facial display, whereas the processing conflict account assumes an affective conflict triggered by incongruent combinations of emotion and the affective connotation of group membership. In three experiments, we aimed at further substantiating the processing conflict account by separating the affective conflict from potential social intentions. For this, we created a new paradigm, in which the participant was an outside observer of a social interaction scene between two faces. Participants were required to respond to the emotional target person that could represent an ingroup or outgroup member. In all three experiments, irrespective of any social intention, responses were consistently affected by the group relation between participant and emotional target, i.e., the affective (in)congruency of the target seen by participants. These results further support the processing conflict account. The implications for the two theoretical accounts are discussed.

The effect of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive control in multitasking.

Current research in brain stimulation suggests transcutaneous auricular vagus nerve stimulation (taVNS) as a promising tool to modulate cognitive functions in healthy populations, such as attention, memory, and executive functions. Empirical evidence in single-task contexts, suggests that taVNS promotes holistic task processing, which strengthens the integration of multiple stimulus features in task processing. However, it is unclear how taVNS might affect performance in multitasking, where the integration of multiple stimuli leads to an overlap in stimulus response translation processes, increasing the risk of between-task interference (crosstalk). In a single-blinded, sham-controlled, within-subject design, participants underwent taVNS while performing a dual task. To assess the effects of taVNS, behavioral (reaction times), physiological (heart rate variability, salivary alpha-amylase), and subjective psychological variables (e.g., arousal) were recorded over three cognitive test blocks. Our results revealed no overall significant effect of taVNS on physiological and subjective psychological variables. However, the results showed a significant increase in between-task interference under taVNS in the first test block, but not in the subsequent test blocks. Our findings therefore suggest that taVNS increased integrative processing of both tasks early during active stimulation.

Valence moderates the effect of stimulus-hand proximity on conflict processing and gaze-cueing.

An effective interaction with the environment requires adaptation of one's own behaviour to environmental demands. We do so by using cues from our environment and relating these cues to our body to predict the outcomes of events. The recent literature on embodied cognition suggests that task-relevant stimuli, presented near the hands, receive more attentional capacity and are processed differently than stimuli, presented spatially more distant to our body. It has also been proposed that near-hand processing is beneficial to conflict resolution. In the current study, we tested the assumption of an attentional bias towards the near hand space in the context of our previous work by combining a cueing paradigm (allocation of visual attention) with a conflict processing paradigm (Simon task) in the near vs far hand space. In addition, the relevance of processing was manipulated by using affective (angry vs neutral smileys) gaze cues (i.e., varying the valence of the cues). Our results indicate that (a) the interaction of valence × cue congruency × hand proximity was significant, indicating that the cueing effect was larger for negative valence in the proximal condition. (b) The interaction of valence × Simon compatibility × stimulus-hand proximity interaction was significant, indicating that for negative valence processing, the Simon effect was smaller in the proximal than in the distal stimulus-hand condition. This effect was at least numerically but not significantly reversed in the neutral valence condition. (c) Overall, cue congruency, indicating the correct vs incorrect attention allocation to the target stimulus onset, did not reveal any effect on Simon compatibility × stimulus-hand proximity. Our results suggest that valence, the allocation of attention, and conflict, seem to be decisive factors determining the direction and strength of hand proximity effects.

Modulation of the executive control network by anodal tDCS over the left dorsolateral prefrontal cortex improves task shielding in dual tasking.

Task shielding is an important executive control demand in dual-task performance enabling the segregation of stimulus-response translation processes in each task to minimize between-task interference. Although neuroimaging studies have shown activity in left dorsolateral prefrontal cortex (dlPFC) during various multitasking performances, the specific role of dlPFC in task shielding, and whether non-invasive brain stimulation (NIBS) may facilitate task shielding remains unclear. We therefore applied a single-blind, crossover sham-controlled design in which 34 participants performed a dual-task experiment with either anodal transcranial direct current stimulation (atDCS, 1 mA, 20 min) or sham tDCS (1 mA, 30 s) over left dlPFC. Task shielding was assessed by the backward-crosstalk effect, indicating the extent of between-task interference in dual tasks. Between-task interference was largest at high temporal overlap between tasks, i.e., at short stimulus onset asynchrony (SOA). Most importantly, in these conditions of highest multitasking demands, atDCS compared to sham stimulation significantly reduced between-task interference in error rates. These findings extend previous neuroimaging evidence and support modulation of successful task shielding through a conventional tDCS setup with anodal electrode over the left dlPFC. Moreover, our results demonstrate that NIBS can improve shielding of the prioritized task processing, especially in conditions of highest vulnerability to between-task interference.

Opposing influences of global and local stimulus-hand proximity on crosstalk interference in dual tasks.

In contrast to traditional dualistic views of cognition, visual stimulus processing appears not independent of bodily factors such as hand positioning. For example, reduced crosstalk between two temporally overlapping tasks has been observed when the hands are moved into the attentional window alongside their respective stimuli (i.e., establishing global stimulus-hand proximity). This result indicates that hand-specific attentional processing enhancements support a more serial rather than parallel processing of the two tasks. To further elucidate the nature of these processing modulations and their effect on multitasking performance, the present study consisted of three interrelated crosstalk experiments. Experiment 1 manipulated global stimulus-hand proximity and stimulus-effect proximity orthogonally, with results demonstrating that hand proximity rather than effect proximity drives the crosstalk reduction. Experiment 2 manipulated the physical distance between both hands (i.e., varying local stimulus-hand proximity), with results showing weak evidence of increased crosstalk when both hands are close to each other. Experiment 3 tested opposing influences of global and local stimulus-hand proximity as observed in Experiment 1 and 2 rigorously within one experiment, by employing an orthogonal manipulation of these two proximity measures. Again, we observed slightly increased crosstalk for hands close to each other (replicating Experiment 2); however, in contrast to Experiment 1, the effect of global stimulus-hand proximity on the observed crosstalk was not significant this time. Taken together, the experiments support the notion of hand-specific modulations of perception-action coupling, which can either lead to more or less interference in multitasking, depending on the exact arrangement of hands and stimuli.

How perceived maternal gatekeeping affects fathers: An 8-week study.

Maternal gatekeeping describes mothers' attempts to influence father involvement in child-rearing. While the effect of maternal gatekeeping on the father-child relationship has been explored, less is known about how fluctuations in the perception of maternal gatekeeping influences fathers' family outcomes and whether father's attachment might moderate these associations. Building on family systems theory, this study explores the within-person effect of negative maternal gatekeeping on father's weekly reports of romantic relationship quality and feelings of exclusion from the family and tests father attachment as a moderator of these associations. Two hundred seventy-seven Canadian and German fathers with children under the age of 6 took part in an 8-week online diary study. Data were analyzed using multilevel structural equation modeling. During weeks when fathers perceived more maternal gatekeeping than was typical, they reported lower positive romantic relationship quality, higher negative romantic relationship quality, and felt more excluded from the family system. Avoidant attachment moderated the within-person effect of perceived maternal gatekeeping on negative romantic relationship quality, such that within-person increases in perceived maternal gatekeeping were more strongly linked with higher than-average negative romantic relationship quality among more avoidant fathers. Our findings shed new light on the within-person effects of perceived maternal gatekeeping on fathers' feelings regarding the family system. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis.

BACKGROUND: Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet. METHODS: The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release. RESULTS: While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity. CONCLUSION(S): Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers NA release. Moreover, our results highlight the benefits of data pooling and data sharing in order to allow stronger conclusions in research.

No reduction of between-task interference in a dual-task with a repeating sequence of SOAs.

A frequent observation in dual-tasking is that spatially or conceptually (in)compatible Task 2 response features can interfere with responses in Task 1 (backward crosstalk effect; BCE). Such between-task interference is, at least to some degree, under strategic control. It has been shown that the size of the BCE can be modulated by instructions, contextual regularities, recent experience of conflict, and motivational factors. Especially large temporal task overlap (i.e., short stimulus onset asynchrony, SOA) represents a condition of potentially high levels of between-task interference. Accordingly, Fischer and Dreisbach (2015) showed that specific stimuli, associated with mostly short SOAs, were able to reduce the size of the BCE. In the present study, we investigated whether a regular sequence of SOAs can also be used for contextual regulation of the BCE. In a dual-task with spatially (in)compatible hand- and foot-responses, we implemented a repeating sequence of three SOAs. If participants learned this sequence and used it for task shielding, the BCE should decrease over time in the sequence blocks, but should increase in a subsequent random block. However, this prediction was not supported in two experiments (N = 32 each). Instead, the size of the BCE was constant across all blocks (BFs10 < 1 for the respective interactions). This is an important result, as it points at the necessity to discover the appropriate conditions allowing implicit SOA sequence learning and to further investigate whether or how the resulting implicit sequence knowledge can serve shielding against between-task interference.

Exploring Neural Signal Complexity as a Potential Link between Creative Thinking, Intelligence, and Cognitive Control.

Functional connectivity studies have demonstrated that creative thinking builds upon an interplay of multiple neural networks involving the cognitive control system. Theoretically, cognitive control has generally been discussed as the common basis underlying the positive relationship between creative thinking and intelligence. However, the literature still lacks a detailed investigation of the association patterns between cognitive control, the factors of creative thinking as measured by divergent thinking (DT) tasks, i.e., fluency and originality, and intelligence, both fluid and crystallized. In the present study, we explored these relationships at the behavioral and the neural level, based on N = 77 young adults. We focused on brain-signal complexity (BSC), parameterized by multi-scale entropy (MSE), as measured during a verbal DT and a cognitive control task. We demonstrated that MSE is a sensitive neural indicator of originality as well as inhibition. Then, we explore the relationships between MSE and factor scores indicating DT and intelligence. In a series of across-scalp analyses, we show that the overall MSE measured during a DT task, as well as MSE measured in cognitive control states, are associated with fluency and originality at specific scalp locations, but not with fluid and crystallized intelligence. The present explorative study broadens our understanding of the relationship between creative thinking, intelligence, and cognitive control from the perspective of BSC and has the potential to inspire future BSC-related theories of creative thinking.

Two types of between-task conflict trigger respective processing adjustments within one dual-task.

In dual tasking, two different kinds of between-task conflict occur. Because in both cases, Task 2 characteristics affect Task 1 performance, they are commonly referred to as backward crosstalk effects (BCE): One with a conflict at the response selection stage when Task 1 and Task 2 have dimensional overlap (the compatibility-based BCE) and one with a conflict at the motor execution stage when response inhibition resulting from a Task 2 no-go-trial interferes with simultaneous response execution in Task 1 (the no-go BCE). Recent research suggests that these BCEs differ not only in their underlying cognitive processes, but also in how cognitive control is regulated. Here, we investigated whether both can be produced in a single dual-task set up and whether they trigger their respective processing adjustments (i.e., a sequential modulation). In three experiments, participants categorized numbers as smaller or larger than 5 in Task 1. In Experiments 1 and 2, numbers were responded to irrespective of numerical size (go-response) as Task 2. Further, dimensional overlap was provided by (non)corresponding size information in both stimuli, which was strengthened in Experiment 2 by presenting S1 and S2 in the same/different color in compatible/incompatible trials, respectively. In Experiment 3, participants were required to perform a number-size categorization also in Task 2, establishing strong dimensional overlap by activating the same or different response categories in both tasks. In all three experiments, the number 5 served as the no-go stimulus in Task 2 to induce a no-go BCE on Task 1. By and large, our results show that both types of between-task conflicts not only occur within the same type of BCE, but they also trigger their respective sequential modulation.

Accelerated forest fragmentation leads to critical increase in tropical forest edge area.

Large areas of tropical forests have been lost through deforestation, resulting in fragmented forest landscapes. However, the dynamics of forest fragmentation are still unknown, especially the critical forest edge areas, which are sources of carbon emissions due to increased tree mortality. We analyzed the changes in forest fragmentation for the entire tropics using high-resolution forest cover maps. We found that forest edge area increased from 27 to 31% of the total forest area in just 10 years, with the largest increase in Africa. The number of forest fragments increased by 20 million with consequences for connectivity of tropical landscapes. Simulations suggest that ongoing deforestation will further accelerate forest fragmentation. By 2100, 50% of tropical forest area will be at the forest edge, causing additional carbon emissions of up to 500 million MT carbon per year. Thus, efforts to limit fragmentation in the world's tropical forests are important for climate change mitigation.

Tackling unresolved questions in forest ecology: The past and future role of simulation models.

Understanding the processes that shape forest functioning, structure, and diversity remains challenging, although data on forest systems are being collected at a rapid pace and across scales. Forest models have a long history in bridging data with ecological knowledge and can simulate forest dynamics over spatio-temporal scales unreachable by most empirical investigations.We describe the development that different forest modelling communities have followed to underpin the leverage that simulation models offer for advancing our understanding of forest ecosystems.Using three widely applied but contrasting approaches - species distribution models, individual-based forest models, and dynamic global vegetation models - as examples, we show how scientific and technical advances have led models to transgress their initial objectives and limitations. We provide an overview of recent model applications on current important ecological topics and pinpoint ten key questions that could, and should, be tackled with forest models in the next decade.Synthesis. This overview shows that forest models, due to their complementarity and mutual enrichment, represent an invaluable toolkit to address a wide range of fundamental and applied ecological questions, hence fostering a deeper understanding of forest dynamics in the context of global change.

Lianas in silico, ecological insights from a model of structural parasitism.

Tropical forests are a critical component of the Earth system, storing half of the global forest carbon stocks and accounting for a third of terrestrial photosynthesis. Lianas are structural parasites that can substantially reduce the carbon sequestration capacity of these forests. Simulations of this peculiar growth form have only recently started and a single vegetation model included lianas so far. In this work we present a new liana implementation within the individual based model Formind. Initial tests indicate high structural realism both horizontal and vertical. In particular, we benchmarked the model against empirical observations of size distribution, mean liana cluster size and vertical leaf distribution for the Paracou site in French Guiana. Our model predicted a reduction of above-ground biomass between 10% for mature stands to 45% for secondary plots upon inclusion of lianas in the simulations. The reduced biomass was the result of a lower productivity due to a combination of lower tree photosynthesis and high liana respiration. We evaluated structural metrics (LAI, basal area, mean tree-height) and carbon fluxes (GPP, respiration) by comparing simulations with and without lianas. At the equilibrium, liana productivity was 1.9t C ha - 1 y - 1 , or 23% of the total GPP and the forest carbon stocks were between 5% and 11% lower in simulations with lianas. We also highlight the main strengths and limitations of this new approach and propose new field measurements to further the understanding of liana ecology in a modelling framework.

When a smile is a conflict: Affective mismatch between facial displays and group membership induces conflict and triggers cognitive control.

Affective responses to emotional expressions critically depend on the expresser's group membership: Facial displays by in-group members elicit concordant affective behavior in the perceiver whereas out-group expressions elicit discordant behavior. A prominent explanation for this response divergence assumes that initial affective responses are elicited by the social message signaled by facial displays (social intentions account). In this study we tested an alternative account, proposing that specific combinations of group membership and facial expression (i.e., positive expressions by negatively evaluated out-group members or negative expressions by positively evaluated in-group members) result in affective conflict (processing conflict account). In 4 experiments White participants executed simple 2-choice categorization tasks on pictures of emotions expressed by Middle-Eastern (out-group) or White persons (in-group). We observed consistent performance decrements to affectively incongruent compared with congruent faces. Moreover, consistent with the processing conflict account, experienced conflict from affectively incongruent faces reactively induces recruitment of cognitive control resources. Conflict adaptation effects occurred (a) irrespective of the type of conflict and (b) also for emotional facial expressions for which the underlying social message does not vary with group membership. In summary, these results substantiate the processing conflict hypothesis. Consequences for the prominent social intentions account are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Aftereffects and deactivation of completed prospective memory intentions: A systematic review.

Prospective memory, the ability to perform an intended action in the future, is an essential aspect of goal-directed behavior. Intentions influence our behavior and shape the way we process and interact with our environment. One important question for research on prospective memory and goal-directed behavior is whether this influence stops after the intention has been completed successfully. Are intention representations deactivated from memory after their completion, and if so, how? Here, we systematically review 20 years of research on intention deactivation and so-called aftereffects of completed intentions across different research fields to offer an integrative perspective on this topic. We first introduce the currently dominant accounts of aftereffects (inhibition vs. retrieval) and illustrate the paradigms, findings, and interpretations that these accounts developed from. We then review the evidence for each account based on the extant research in these paradigms. While early studies proposed a rapid deactivation or even inhibition of completed intentions, more recent studies mostly suggested that intentions continue to be retrieved even after completion and interfere with subsequent performance. Although these accounts of aftereffects seem mutually exclusive, we will show that they might be two sides of the same coin. That is, intention deactivation and the occurrence of aftereffects are modulated by a multitude of factors that either foster a rapid deactivation or lead to continued retrieval of completed intentions. Lastly, we outline future directions and novel experimental procedures for research on mechanisms and modulators of intention deactivation and discuss practical implications of our findings. (PsycINFO Database Record (c) 2020 APA, all rights reserved).