[Lormetazepam in preoperative sleeplessness. Dose dependance of the effect and comparison with 100 mg pentobarbital (author's transl)]. / Lormetazepam bei präoperativen Schlafstörungen. Dosisabhängigkeit der Wirkung und Vergleich zu 100 mg Pentobarbital.

Lormetazepam (0.5, 1, 2, 4, 8 mg)--a new benzodiazepine--was tested versus Pentobarbital (100 mg) under double blind conditions on 240 preoperative inpatients for night-time sedative and side effects after acute oral intake. Results are based on p less than 0.05. Additionally p less than 0.125 in binomial-two-sample-tests was accepted. Lormetazepam shows dose dependent increase in hypnotic effects (e.g. reduction in sleep latency and number of awakenings, increase of total sleep duration), and side effects (e.g. dopiness, dizziness), but no relevant change in vital signs. About 0.5 mg of Lormetazepam are equivalent to 100 mg of Pentobarbital. 2 mg of Lormetazepam seem to be the optimum dose regarding the relation between hypnotic and side effects. In the view of anaesthesists Lormetazepam is preferable to Pentobarbital because of more favorable safety aspects.

The third crus of the anthelix and another minor anomaly of the external ear.

One minor anomaly of the external ear is a "third crus", which is an addition to the normal upper and lower crura at the anterior end of the anthelix. Another minor deformity is an extension of the crus of the helix, wherein it runs as a crest across the concha. An operation to correct the latter deformity is described.

Mondor's disease. An unusual complication of mammaplasty.

We present 6 cases of Mondor's disease which developed after plastic surgical operations on the breasts. All signs of the disease disappeared spontaneously after 3 or 4 months.