[Morphogenesis of Far Eastern tick-borne encephalitis].

Based on their findings and the data available in the literature, the authors provide the current interpretation of tickborne encephalitis (TBE) in terms of the immunopathological essence of inflammation. The pathomorphological pattern of the central nervous system is shown to reflect the hyperergic nature of inflammation in TBE. The progressive development of the immediate hypersensitivity reactions initiated by the damaging action of the virus on brain tissue and the delayed hypersensitivity ones that provide the formation of local (tissue) immunity. Integrated assessment of human and experimental TBE-induced pathology has established the variability in its manifestations, which depends on the properties of an initiating virus strain, the type of the body's virus-induced immune response, and the stage of morphogenesis of the disease. On this basis, the authors identified 3 clinical and morphological variants of manifestation of an infectious process in TBE.

[Experimental tick-borne encephalitis in golden hamsters treated with specific immunotherapy]. / Eksperimental'nyi kleshchevoii éntsefalit u zolotistykh khomyachkov na fone spetsificheskoi immunoterapii.

Efficiency of various protocols of specific immunoglobulin treatment was evaluated in golden hamsters inoculated with two Far Eastern tick-borne encephalitis (TBE) strains. After a low therapeutic dose (0.1 ml) of immunoglobulin, corresponding to total dose (60 ml) per course, all parameters (survival, immunogenicity, pathomorphology of the brain) deteriorated in animals infected with both strains. A higher dose (0.2 ml) corresponding to total dose of 120 ml notably improved all the studied parameters. The efficiency of specific immunoglobulin depends on the clinical and pathogenetic characteristics of TBE, determined by the properties of TBE strains. The results validate therapy and prevention of TBE by high-titer immunoglobulin in adequate total dose, monitored by blood analyses for TBE antigen and evaluations of the time course of IgM antibodies.

[Pathogenetic criteria for evaluating the virulence of tick-borne encephalitis strains isolated in the southern part of the Far East]. / Patogeneticheskie kriterii otsenki virulentnosti shtammov virusa kleshchevogo éntsefalita, izolirovannykh na iuge dal'nego vostoka.

A comparative virological, immunological, and pathohistological study of 5 tick-borne encephalitis (TBE) strains differing by virulence was carried out in golden hamsters. The authors characterize the TBE virus pathogenicity sign, denoted as Pmaic genetic marker (pathogenicity for hamsters at intracerebral inoculation), which helps understand the essence of immunopathogenetic mechanisms of the TBE infectious process in man.