RESUMO
When two sequences are aligned with a single set of alignment parameters, or when mutation parameters are estimated on the basis of a single "optimal" sequence alignment, the variability of both the alignment and the estimated parameters can be seriously underestimated. To obtain a more realistic impression of the actual uncertainty, we propose sampling sequence alignments and mutation parameters simultaneously from their joint posterior distribution given the two original sequences. We illustrate our method with human and orangutan sequences from the hyper variable region I and with gene-pseudogene pairs.
Assuntos
Alinhamento de Sequência/métodos , Animais , Evolução Molecular , Humanos , Funções Verossimilhança , Modelos Estatísticos , Pongo pygmaeus , PseudogenesRESUMO
Clinical findings on irritable bowel syndrome in adults and recurrent abdominal pain in children are reviewed to determine if what is known about each disorder can illuminate our understanding of the other. The evidence reveals striking similarities between the disorders in prevalence, course, medical and psychiatric comorbidity, family medical and psychiatric history, and association with life events. Continuity between the two disorders is also suggested by the results of follow-up and follow-back studies. The review shows the importance of a developmental perspective for understanding functional bowel disorders in adults and points to areas where further research would be useful.
