Comparación del efecto del FZ con un anthiperglucemiante de mecanismo de acción similar, la acarbosa, en perros beagle / Comparison of FZ and acarbosa anthyperglucemic effct, in beagles

INTRODUCCIÓN. El FZ es una zeolita natural modificadas, la nueva conformación espacial le otorga una selectividad para la captura de glucosa del medio, mostrando un efecto similar al de medicamentos conocidos como antihiperglucemiantes, entre otros la Acarbosa, el Fibraguar y el Miglitol. OBJETIVO. Comparar el efecto antihiperglucemiante del FZ con el de la Acarbosa. MATERIAL Y MÉTODOS. Se utilizaron 20 perros Beagles que se distribuyeron en 5 grupos. A todos los animales se les suministró igual cantidad de pienso; el grupo 1 lo recibió solo, al grupo 2 se adicionó un suplemento de 50 g de sacarosa y los grupos 3, 4 y 5 recibieron además del suplemento de 50g de sacarosa, 200 mg de Acarbosa el grupo 3; 5g de FZ el grupo 4 y la combinación de 5g de FZ mas 200mg de Acarbosa el grupo 5. Se extrajo sangre a todos los animales para realizar determinaciones de glicemia al tiempo 0 y a los 30, 60, 90 y 120 minutos después de la ingestión del alimento y los medicamentos. Con los valores de glicemia se confeccionó una curva de tolerancia a los carbohidratos que permitió la comparación entre los grupos. RESULTADOS. Se observa que los grupos bajo tratamiento (3,4 y 5) presentaron valores inferiores de las áreas bajo la curva que el grupo 2 control positivo y el grupo 1 que ingirió solamente pienso. No se observan diferencias entre el grupo al que se administró la combinación de medicamentos y los grupos que recibieron cada uno por separado. CONCLUSIONES. El FZ y la Acarbosa mostraron un efecto antihiperglucemiante similar (AU)

INTRODUCTION. FZ is a natural zeolite that posses a selective action for the capture of glucose, it show a similar effect to antihypergluemics known drugs, like Acarbosa, Fibraguar and Miglitol. OBJECTIVE. Comparing the antihyperglucemic effect of FZ with Acarbosa. MATERIAL AND METHOD. 20 dogs were distributed in 5 groups. Equal quantity of food was supplied to all of the animals; the group 1 received only food, the group 2, 50g supplement of sucrose and the groups 3, 4 and 5 received besides the supplement of 50g of sucrose, 200mg of Acarbosa the group 3; 5g of FZ the group 4 and the combination of 5g of FZ plus 200mg of Acarbosa the group 5. Glycaemia was determinate in time 0,30,60,90 and 120 minutes after the ingestion of food and medications. A curve of tolerance of carbohydrates was manufactured to comparison the treatments. RESULTS. It is observed inferior values of areas under curved in groups (3.4 and 5). No differences were observed between the group with medications. CONCLUSIONS. FZ and Acarbosa showed similar antihyperglucemic effect (AU)

Comparison of the effect of the hipocolesteromiante treatment of the atorvastatin, with the combination atorvastatina-policosanol as well as the possible action on the state oxiation - redution, in patient with vascular affections in lower limbs

It has been shown that a decrease in the concentrations of total cholesterol and LDL-col by diets and drugs reduces the peripheral vascular disease risk. Policosanol and Atorvastatin have shown they are capable of reducing both parameters in type II hypercholesterolemia. Some of the steps in the mechanism of action of these drugs are different and could show results sums, when we used in combination. They also show a pleiotropic effect given by its general antioxidant action on lipid peroxidation. OBJECTIVES. To compare the effect of treatment with the combination with Atorvastatin and Atorvastatin - Policosanol n cholesterol concentrations of atherogenic lipoproteins, and the possible antioxidant action. PATIENTS AND METHODS. We studied 104 patients of both sexes in a range of ages between 40 and 60 years. It was taken as a criterion for inclusion Col-LDL levels above 3.3 mmol/L. Patients were randomly distributed into two groups (one treated with Atorvastatin and the other with Atorvastatin + Policosanol). Measurements were made of serum lipoproteins, and hemodynamic studies and oxidative stress before and after three months of treatment. RESULTS. Was found when comparing the groups among themselves, a decrease (p <0.05) in the values of T Col, Col-LDL, TG, VLDL and RAC. Average values were lower (p <0.05) from Col-LDL in the group treated with the combination of both drugs, as well as variations in the parameters which measure oxidative stress ( GSH (p <0.05) increased and MDA decreased). CONCLUSION. The combination of Policosanol and Atorvastatin in the treatment of hypercholesterolemic patients offers better results than using each separately (AU)

No disponible