RESUMO
N-(4-[(1-(Dimethylamino)-ethylidene)-amino]-phenyl)-2 methoxyacetamide hydrochloride (amidantel, BAY d 8815) is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundworms. Amidantel was well tolerated by all animals tested and did not show teratogenic effects.
Assuntos
Anti-Helmínticos/farmacologia , Fenilenodiaminas/farmacologia , Animais , Anti-Helmínticos/uso terapêutico , Anti-Helmínticos/toxicidade , Gatos , Fenômenos Químicos , Química , Cães , Helmintíase/tratamento farmacológico , Dose Letal Mediana , Camundongos , Fenilenodiaminas/uso terapêutico , Fenilenodiaminas/toxicidade , Coelhos , RatosRESUMO
Praziquantel (2 - cyclohexylcarbonyl - 1,3,4,6,7,11b - hexahydro - 2H - pyrazino (2,1 - a) isoquinolin - 4 - one) was tested against artificially established infections of Taenia hydatigena in 39 dogs. The formulation used was a 660 mg tablet containing 50 mg of active ingredient (ai). A single oral dose at 1 mg/kg ai completely removed 14-day-old infections in all dogs. 2.5 mg/kg ai praziquantel was completely effective against 7, 14 and 28-day-old worms. 5 mg/kg ai completely removed two-day-old infestations. No side effects were seen in any treated dog.
