RESUMO
A case of Actinomyces hongkongensis pelvic actinomycosis in an adult woman is described. Conventional phenotypic tests failed to identify the Gram-positive bacillus isolated from a fluid aspirate of a pelvic abscess. The bacterium was identified by 16S rRNA gene sequencing and analysis using the SmartGene Integrated Database Network System software.
Assuntos
Abscesso/microbiologia , Actinomyces/classificação , Actinomyces/isolamento & purificação , Actinomicose/microbiologia , Doença Inflamatória Pélvica/microbiologia , Actinomyces/genética , Técnicas de Tipagem Bacteriana , Análise por Conglomerados , Biologia Computacional , DNA Bacteriano/química , DNA Bacteriano/genética , DNA Ribossômico/química , DNA Ribossômico/genética , Feminino , Humanos , Pessoa de Meia-Idade , Dados de Sequência Molecular , Filogenia , RNA Ribossômico 16S/genética , Análise de Sequência de DNAAssuntos
Adenocarcinoma/complicações , Adenocarcinoma/epidemiologia , Vasculite por IgA/etiologia , Neoplasias da Próstata/complicações , Neoplasias da Próstata/epidemiologia , Adenocarcinoma/diagnóstico , Idade de Início , Idoso , Biópsia , Humanos , Vasculite por IgA/diagnóstico , Imunoglobulina A/metabolismo , Masculino , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/diagnóstico , Pele/patologiaRESUMO
This review summarizes the main aspects and newest findings of how proteinase-activated receptor 1 (PAR-1) may modulate programmed cell death. Activation of PAR-1 has been found to induce or inhibit apoptosis in a variety of cells, depending on the dosage of its physiological agonist thrombin, or that of synthetic receptor activators. To date, cellular targets for PAR-1-mediated effects on apoptosis include neuronal, endothelial, and epithelial cells, fibroblasts, and tumor cells. The signaling pathways involved in the induction or prevention of apoptosis by PAR-1 activation are diverse, and include JAK/STAT, RhoA, myosin light chain kinase, ERK1/2, and various Bcl-2 family members. In view of the well-established involvement of microbial proteinases in host tissue malfunction, the article also elaborates on the possible significance of PAR-1 activation for the pathogenesis of infectious disease.
