[A test for evaluating specificity and course of tilt table testing based on two groups of healthy volunteers (adolescent athletic swimmers and controls)]. / Próba oceny swoistosci i przebiegu testu pochyleniowego w oparciu o badania dwóch grup zdrowych ochotników (mlodziezy wyczynowo uprawiajacej plywanie i grupy jej rówiesników).

The aim of this study was to estimate the results of tilt table testing in two groups of healthy adolescents--swimmers and control. Cardio-vascular reactions on tilting were determined by the measurements of heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP). The study was carried out in accordance with the Polish Cardiac Society procedure. The positive tilt table testing results were observed in most young swimmers and in about thirty per cent of controls. The differences in the cardiovascular reactions were observed, too. The clinical interpretation and usefulness of these results must be established by future investigations.

[Detection of silent ischemia symptoms in patients with carbohydrate metabolism disorders]. / Badania nad obecnoscia bezbólowej postaci choroby niedokrwiennej serca u chorych z zaburzeniami gospodarki weglowodanowej.

Early detection of silent ischaemia plays an important role in prevention of sudden cardiac death. Glucose metabolism disturbances are important risk factor of ischaemic heart disease. More frequent occurrence of silent ischaemia in patients with diabetes mellitus has been reported in several studies. We studied 24-hour Holter ECG monitoring of 335 patients with stable angina pectoris. Patients were divided in two groups. The first group consisted of 158 patients with glucose metabolism disturbances, the second-controlled group consisted of 177 patients without these disturbances. The aim of this study was to analyse the frequency of occurrence of silent ischaemia according to the grade of glucose metabolism disturbances. We only found that silent ischaemia is more frequent in patients with higher grade glucose metabolism disturbances. Additionally, we found that more frequent occurrence of silent ischaemia may depend on coexisting hypertension and hypertriglyceridemia. The comparison of Holter ECG monitoring and exercise test in detection of silent ischaemia has shown that both methods are useful in the detection of silent ischaemia.

[Aztreonam--new antibiotic for treating infections caused by gram-negative aerobic bacteria]. / Aztreonam--nowy antybiotyk w leczeniu zakazen wywolywanych przez gram-ujemne bakterie tlenowe.

Aztreonam is the first synthetic monobactam used in practical medicine. It is effective in Gram-negative aerobe infections. It inhibits the growth of most Enterobacteriaceae in concentrations below 2 mg/ml, and of Pseudomonas aeruginosa below 16 mg/ml. It shows a widespread, distribution achieving effective therapeutic concentration there, where infections are seen most frequently. The half-life is from 1.6 to 2.0 hours. It can be administered to patients every 8 and 12 hours in single parenteral doses of 0.5, 1.0, and 2.0 g. Aztreonam is a non-toxic antibiotic, a weak hapten with slight allergenicity. It has found therapeutic use together with the antibiotics directed against aerobic and anaerobic bacterial Gram-positive flora, and it is used in the therapy directed against infections with Gram-negative aerobes. It is an effective antibiotic in nosocomial infections, in oncological patients with neutropenia, and in elderly patients.

Enzyme activities in hepatic venous blood under strenuous physical exercise.

In order to study the influence of physical exercise on liver function, experiments were performed in healthy volunteers subjected to controlled major physical effort. Blood samples obtained by catheterization of hepatic vein during exercise were analyzed for activities of LD (thermostabile and thermolabile isoenzymes), AlAT, SDH, ICD, AP and CPK, and these activities were compared with corresponding values in arterial blood samples taken simultaneously. Hepatic blood flow and oxygen saturation of hepatic venous blood were measured. Physical exercise resulted both in diminished hepatic blood flow and a fall in hepatic venous oxygen saturation. These changes were accompanied by release of liver specific enzymes, indicating that exhausting exercise may induce an "increased hepatocyte membrane permeability" in man.