Relationships between bone mineral density and cell size in cervical smears, serum estradiol levels, and anthropometric characteristics.

OBJECTIVE: To evaluate relationships between bone mineral density and morphometric characteristics of squamous cells in cervical smears, serum estradiol levels, body weight, and body mass index. METHOD: Dual X-ray absorptiometry measurements were performed in 107 women who had recently undergone routine screening for cervical cancer. Serum estradiol levels were determined. Mean areas for squamous cells, squamous cell nuclei, and squamous cell cytoplasm were calculated, as well as the nucleus area to cytoplasm area ratio. RESULTS: The mean cell and cytoplasmic areas were significantly lower in women with lower T scores for femoral neck and lumbar spine (P<0.001). Mean T scores were significantly lower for the women with atrophic cells than for those with mature cells (P<0.001). A correlation between estradiol levels and T scores was found for the lumbar spine (P<0.05) but not for the femoral neck. Multiple linear regression analysis showed the cytoplasmic area to be the most significant predictor of T scores for the total hip, followed by BMI and age, and to be the only significant predictor of T scores for the total spine. CONCLUSION: Relationships were found between bone mineral density and both the total cell and cytoplasmic areas of squamous cells obtained from cervical smears.

Etidronate does not suppress periprosthetic bone loss following cemented hip arthroplasty.

Periprosthetic bone loss after arthroplasty may threaten prosthesis survival. The current study investigated the effect of etidronate therapy on periprosthetic, contralateral hip, and spine bone mineral density (BMD) in a one-year, prospective, randomized, double-blind study on 46 patients after cemented hip arthroplasty. BMD was measured with dual-energy X-ray absorptiometry (DXA). There were no significant differences between mean BMD measurements of the etidronate and placebo groups, with the exception of the mean percent change in the spine at six months and 12 months and in Gruen zone 3 at six months; in all three cases, the etidronate group had significantly greater mean values. These findings suggest that cyclic etidronate therapy has no significant effect in suppressing periprosthetic bone loss following cemented hip arthroplasty.

Late results of modified Mitchell procedure for the treatment of hallux valgus.

From a total of 153 patients (251 feet), 64 (41.8%) patients, who had had 105 modified Mitchell procedures, were clinically and radiographically examined with follow-up periods ranging from 15 to 24 years (mean, 21 years). Mean age at operation was 41 years (range, 12-64 years). The classic double osteotomies, which diverged slightly toward the plantar surface and the distal fragment, shifted laterally, and angled plantarward, were fixed with a smooth Kirschner wire. In this way, it was possible to achieve a reduction in the first intermetatarsal angle from an average of 22.5 degrees preoperatively to 7.7 degrees postoperatively, and the hallux valgus angle changed from an average of 33 degrees to 17 degrees, with an average shortening of the first metatarsal of 5.4 mm and an average lateral displacement of the first metatarsal head of 4.5 mm. In 67 feet (64%), the results were graded good to excellent; in 23 feet (22%), satisfied; and in 15 feet (14%), poor. The results were worse than the results obtained on the same patient population with a follow-up ranging from 2 to 11 years, with 97% good-to-excellent results reported. Pain over bunion caused by recurrence of the hallux valgus deformity was the main reason for this late deterioration of the results.

Displaced subcapital fracture of the hip in transient osteoporosis of pregnancy. A case report.

We describe a case of displaced subcapital fracture of the hip in a woman in the third trimester of her first pregnancy. A pathological fracture occurred in a previously painful hip, and radiographs showed pronounced osteopenia of the femoral head and neck. Closed reduction and internal fixation was carried out 2 weeks after delivery when the osteopenia was still severe. Healing of the fracture followed with recovery of hip movements.